Cited by 476Atrial Fibrillation Management and OutcomesCardiac pacing and defibrillation studiesCardiac Arrhythmias and Treatments

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Clinical Outcomes After Ablation and Pacing Therapy for Atrial Fibrillation: A Meta-Analysis

Wood, Mark A., Brown-Mahoney, Chris, Kay, G. Neal, Ellenbogen, Kenneth A.·2000·Circulation

DOI 10.1161/01.cir.101.10.1138

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Abstract

BACKGROUND: Radiofrequency ablation of the atrioventricular node and permanent pacing are used for symptomatic relief in patients with medically refractory atrial fibrillation. In this study, meta-analysis was used to clarify clinical outcomes and survival after ablation and pacing therapy using data from the published literature. METHODS AND RESULTS: We used 21 studies with a total of 1181 patients in the meta-analysis. All patients had medically refractory atrial tachyarrhythmias, primarily atrial fibrillation (97%). Nineteen measures of clinical outcome, encompassing quality of life, ventricular function, exercise duration, and healthcare use, were derived from the studies. The meta-analysis demonstrated significant improvement after ablation and pacing therapy in all outcome measures except fractional shortening, which demonstrated a trend toward improvement (P=0.08). Ejection fraction did show significant improvement (P<0.001). The calculated 1-year total and sudden death mortality rates after ablation and pacing therapy were 6.3% and 2.0%, respectively. CONCLUSIONS: Ablation and pacing therapy improves a broad range of clinical outcomes for patients with medically refractory atrial fibrillation. The calculated 1-year mortality rates after this therapy are low and comparable with medical therapy.

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Authors: Wood, M. A., Brown-Mahoney, C., Kay, G. N., & Ellenbogen, K. A.
Affiliations: University of Minnesota (US)
ORCID: Kay, G. Neal
Ellenbogen, Kenneth A.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2000-03-14
Volume: 101
Issue: 10
Pages: 1138-1144
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.101.10.1138
OpenAlex: W2069728923
Cited by: 476
References: 43
Citations by year: 2026: 12 · 2025: 9 · 2024: 9 · 2023: 13 · 2022: 19 · 2021: 16 · 2020: 7 · 2019: 5 · 2018: 11 · 2017: 9 · 2016: 15 · 2015: 6 · 2014: 15 · 2013: 18 · 2012: 26
FWCI: 4.22
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords: atrial fibrillation, radiofrequency catheter ablation, atrioventricular node ablation, permanent pacemaker, mortality, sudden death, quality of life, ejection fraction, ventricular function, health care utilization
MeSH terms: Aged, Atrial Fibrillation, Cardiac Pacing, Artificial, Clinical Trials as Topic, Female, Humans, Male, Middle Aged, Survival Analysis, Treatment Outcome, Catheter Ablation

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Clinical Outcomes After Ablation and Pacing Therapy for Atrial Fibrillation: A Meta-Analysis

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