Cited by 937Diabetes, Cardiovascular Risks, and LipoproteinsLipoproteins and Cardiovascular HealthLipid metabolism and disorders

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Hypertriglyceridemic Waist: A Marker of the Atherogenic Metabolic Triad (Hyperinsulinemia; Hyperapolipoprotein B; Small, Dense LDL) in Men?

Lemieux, Isabelle, Pascot, Agnès, Couillard, Charles, Lamarche, Benoı̂t, Tchernof, André, Alméras, Natalie, Bergeron, Jean, Gaudet, Daniel, Tremblay, Gérald, Prud’homme, Denis, Nadeau, André, Després, Jean-Pierre·2000·Circulation

DOI 10.1161/01.cir.102.2.179

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Abstract

Background —The present study tested the hypothesis that simple variables, such as waist circumference and fasting plasma triglyceride (TG) concentrations, could be used as screening tools for the identification of men characterized by a metabolic triad of nontraditional risk factors (elevated insulin and apolipoprotein [apo] B and small, dense LDL particles). Methods and Results —Results of the metabolic study (study 1) conducted on 185 healthy men indicate that a large proportion (>80%) of men with waist circumference values ≥90 cm and with elevated TG levels (≥2.0 mmol/L) were characterized by the atherogenic metabolic triad. Validation of the model in an angiographic study (study 2) on a sample of 287 men with and without coronary artery disease (CAD) revealed that only men with both elevated waist and TG levels were at increased risk of CAD (odds ratio of 3.6, P <0.03) compared with men with low waist and TG levels. Conclusions —It is suggested that the simultaneous measurement and interpretation of waist circumference and fasting TG could be used as inexpensive screening tools to identify men characterized by the atherogenic metabolic triad (hyperinsulinemia, elevated apo B, small, dense LDL) and at high risk for CAD.

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Modifiable Clinical Correlates of Vascular Health in Children and Adolescents with Dyslipidemia
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“Indeed, visceral adipose tissue was found to be more strongly linkedwith the risk of hyperlipidemia [10, 11], insulin resistance [12–14], and diabetes [15, 16] than subcutaneous fat.”
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El fenotipo «hipertrigliceridemia-cintura abdominal aumentada» es un factor de riesgo de aterosclerosis subclínica en pacientes con infección por el virus de la inmunodeficiencia humana
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Obesidad intraabdominal y riesgo cardiometabólico
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Self-citation
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The role of cognitive function in the relationship between surrogate markers of visceral fat and depressive symptoms in general middle-aged and elderly population: A nationwide population-based study
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The hypertriglyceridemic waist phenotype is associated with fatty liver and glycometabolic profiles in overweight and obese adults: a cross-sectional study
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Predictors of Epicardial Fat Volume Decrease after Dapagliflozin Treatment in Patients with Type 2 Diabetes
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Association of “hypertriglyceridemic waist” with increased 5-year risk of subclinical atherosclerosis in a multi-ethnic population: a prospective cohort study
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Hypertriglyceridemic-waist is more predictive of abnormal liver and renal function in an Australian population than a Chinese population.
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Factors Associated with Pre-Hypertension Among Tehranian Adults: A Novel Application of Structural Equation Models
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Clusters of fatty acids in the serum triacylglyceride fraction associate with the disorders of type 2 diabetes
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Hypertriglyceridemic waist phenotype in primary health care: comparison of two cutoff points
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“3% in men and 17% in women, using the cutoff point of Lemieux et al.(3,5) In Malaysia, Zainuddin et al(28) evaluated 298 people aged 18–70 years using two different cutoffs for the HTGW phenotype: IDF(24) and NCEP/ATPIII.”
Influential
Epidemiology of Metabolic Syndrome among Adult Nigerians in a Rural Hospital in Eastern Nigeria
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Authors: Lemieux, I., Pascot, A., Couillard, C., Lamarche, B., Tchernof, A., Alméras, N., Bergeron, J., Gaudet, D., Tremblay, G., Prud’homme, D., Nadeau, A., & Després, J.-P.
Affiliations: Centre hospitalier de l'Université Laval (CA)
From the Quebec Heart Institute, Laval Hospital Research Center; the Lipid Research Center, CHUL Research Center; the Physical Activity Sciences Laboratory, Laval University; the Diabetes Research Unit, CHUL Research Center, Ste-Foy; and the Lipid Clinic, Chicoutimi Hospital, Chicoutimi, Québec, Canada.
ORCID: Lemieux, Isabelle
Couillard, Charles
Lamarche, Benoı̂t
Bergeron, Jean
Gaudet, Daniel
Prud’homme, Denis
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2000-07-11
Volume: 102
Issue: 2
Pages: 179-184
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.102.2.179
OpenAlex: W1991251155
Cited by: 937
References: 0
Citations by year: 2026: 10 · 2025: 19 · 2024: 23 · 2023: 28 · 2022: 31 · 2021: 29 · 2020: 30 · 2019: 26 · 2018: 35 · 2017: 29 · 2016: 38 · 2015: 38 · 2014: 42 · 2013: 42 · 2012: 49
FWCI: 18.34
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
Heart and Stroke Foundation of Canada
Medical Research Council Canada
Medical Research Council
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: hypertriglyceridemic waist phenotype, waist circumference, fasting plasma triglycerides, hyperinsulinemia, apolipoprotein B, small dense LDL, coronary artery disease risk, cardiovascular screening, men
MeSH terms: Abdomen, Adult, Apolipoproteins B, Body Composition, Coronary Artery Disease, Coronary Disease, Humans, Hyperinsulinism, Lipoproteins, LDL, Male, Mass Screening, Middle Aged, Predictive Value of Tests, Risk Factors, Triglycerides, Hypertriglyceridemia, Biomarkers, Coronary Angiography

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Hypertriglyceridemic Waist: A Marker of the Atherogenic Metabolic Triad (Hyperinsulinemia; Hyperapolipoprotein B; Small, Dense LDL) in Men?

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