Cited by 937Diabetes, Cardiovascular Risks, and LipoproteinsLipoproteins and Cardiovascular HealthLipid metabolism and disorders

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Hypertriglyceridemic Waist: A Marker of the Atherogenic Metabolic Triad (Hyperinsulinemia; Hyperapolipoprotein B; Small, Dense LDL) in Men?

Lemieux, Isabelle, Pascot, Agnès, Couillard, Charles, Lamarche, Benoı̂t, Tchernof, André, Alméras, Natalie, Bergeron, Jean, Gaudet, Daniel, Tremblay, Gérald, Prud’homme, Denis, Nadeau, André, Després, Jean-Pierre·2000·Circulation

DOI 10.1161/01.cir.102.2.179

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Abstract

Background —The present study tested the hypothesis that simple variables, such as waist circumference and fasting plasma triglyceride (TG) concentrations, could be used as screening tools for the identification of men characterized by a metabolic triad of nontraditional risk factors (elevated insulin and apolipoprotein [apo] B and small, dense LDL particles). Methods and Results —Results of the metabolic study (study 1) conducted on 185 healthy men indicate that a large proportion (>80%) of men with waist circumference values ≥90 cm and with elevated TG levels (≥2.0 mmol/L) were characterized by the atherogenic metabolic triad. Validation of the model in an angiographic study (study 2) on a sample of 287 men with and without coronary artery disease (CAD) revealed that only men with both elevated waist and TG levels were at increased risk of CAD (odds ratio of 3.6, P <0.03) compared with men with low waist and TG levels. Conclusions —It is suggested that the simultaneous measurement and interpretation of waist circumference and fasting TG could be used as inexpensive screening tools to identify men characterized by the atherogenic metabolic triad (hyperinsulinemia, elevated apo B, small, dense LDL) and at high risk for CAD.

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Background
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Son, Y., Kim, J., Park, H., Park, S. E., Park, C., Lee, W., Oh, K. W., Park, S., & Rhee, E. (2016) · Endocrinology and Metabolism · doi:10.3803/enm.2016.31.1.127 · Cited by 38
Effect of a conventional energy-restricted modified diet with or without meal replacement on weight loss and cardiometabolic risk profile in overweight women
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Adverse drug interaction between risperidone and carbamazepine in a patient with chronic schizophrenia and deficient CYP2D6 activity.
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“High level of plasma triglyceride were regarded as an effective and simple marker for evaluating excess visceral adiposity with a large waistline existing [32, 33].”
Background
Maximal Physiological Responses between Aquatic and Land Exercise in Overweight Women
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“Furthermore, with increased body fat, low levels of cardio protective high density lipoprotein (HDL) are reported (Mansfield, McPherson, & Koski, 1999; Sardinha, Teixeira, Guedes, Going, & Lohman, 2000), in conjunction with elevated low density lipoprotein (LDL) levels (Despres, 1994; Lemieux et al., 2000; Mansfield e…”
Background
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“The HtgW phenotype is represented by the simultaneous presence of elevated serum triglyceride levels and an increased waist circumference [13], and this phenotyope is a major determinant of cardiometabolic risk among Turks [14].”
Background
Comparison of the prevalence of metabolic syndrome and its association with diabetes and cardiovascular disease in the rural population of Bangladesh using the modified National Cholesterol Education Program Expert Panel Adult Treatment Panel III and International Diabetes Federation definitions
Bhowmik, B., Afsana, F., Siddiquee, T., Munir, S. B., Sheikh, F., Wright, E., Bhuiyan, F. R., Ashrafuzzaman, S. M., Mahtab, H., Khan, A. K. A., et al. (2014) · Journal of Diabetes Investigation · doi:10.1111/jdi.12268 · Cited by 36
Examination of encapsulated phytosterol ester supplementation on lipid indices associated with cardiovascular disease.
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Self-citation
The metabolic syndrome and cardiovascular disease
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Carotid intima-media thickness, cardiovascular risk factors and albuminuria in a remote Australian Aboriginal community
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Overall and abdominal obesity indicators had different association with central arterial stiffness and hemodynamics independent of age, sex, blood pressure, glucose, and lipids in Chinese community-dwelling adults
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Comparison of lipid accumulation product with body mass index as an indicator of hypertension risk among Mongolians in China.
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Psychopathology, coronary heart disease and metabolic syndrome in schizophrenia spectrum patients with deficit versus non-deficit schizophrenia: Findings from the CLAMORS study
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Hypertriglyceridemia and Waist Circumference Predict Cardiovascular Risk among HIV Patients: A Cross-Sectional Study
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Self-citation
Effect of Orlistat on Eating Behavior Among Participants in a 3‐year Weight Maintenance Trial
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LDL particle size, fat distribution and insulin resistance in obese children
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Metabolomics Profiling of Visceral Adipose Tissue: Results From MESA and the NEO Study
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“Using the replicated metabolites, to identify novel VAT-associated metabolites beyond known correlates, we additionally sequentially adjusted for the following: (1) fasting glucose concentrations and waist circumference; and (2) plasma triglyceride concentrations, to investigate if and what metabolites remained after…”
Method
Prevalence of hypertriglyceridemic waist and association with risk of type 2 diabetes mellitus: a meta‐analysis
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“The concept of HTGW was first proposed as a marker of atherosclerosis in 2000 [1].”
Background
EVALUATION OF SEVERAL ANTHROPOMETRIC INDICES OF OBESITY AS PREDICTORS OF METABOLIC SYNDROME IN JORDANIAN ADULTS.
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Genetics of metabolic syndrome: Is there a role for phenomics?
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Hypertriglyceridemic Waist: A Simple Marker of High‐Risk Atherosclerosis Features Associated With Excess Visceral Adiposity/Ectopic Fat
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“0 mmol/L and waist circumference ≥90 cm.(13) The identification of the metabolic syndrome was made according to the presence of at least 3 of the following criteria: resting blood pressure ≥130/85 mm Hg, waist circumference ≥102 cm, high-density lipoprotein cholesterol (HDL-C) <1.”
InfluentialSelf-citation
Association between the hypertriglyceridemic waist phenotype and hyperuricemia: a cross-sectional study
Chen, S., Guo, X.-F., Dong, S., Yu, S.-S., Chen, Y.-T., Zhang, N.-J., & Sun, Y.-X. (2017) · Clinical Rheumatology · doi:10.1007/s10067-017-3559-z · Cited by 34

Authors: Lemieux, I., Pascot, A., Couillard, C., Lamarche, B., Tchernof, A., Alméras, N., Bergeron, J., Gaudet, D., Tremblay, G., Prud’homme, D., Nadeau, A., & Després, J.-P.
Affiliations: Centre hospitalier de l'Université Laval (CA)
From the Quebec Heart Institute, Laval Hospital Research Center; the Lipid Research Center, CHUL Research Center; the Physical Activity Sciences Laboratory, Laval University; the Diabetes Research Unit, CHUL Research Center, Ste-Foy; and the Lipid Clinic, Chicoutimi Hospital, Chicoutimi, Québec, Canada.
ORCID: Lemieux, Isabelle
Couillard, Charles
Lamarche, Benoı̂t
Bergeron, Jean
Gaudet, Daniel
Prud’homme, Denis
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2000-07-11
Volume: 102
Issue: 2
Pages: 179-184
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.102.2.179
OpenAlex: W1991251155
Cited by: 937
References: 0
Citations by year: 2026: 10 · 2025: 19 · 2024: 23 · 2023: 28 · 2022: 31 · 2021: 29 · 2020: 30 · 2019: 26 · 2018: 35 · 2017: 29 · 2016: 38 · 2015: 38 · 2014: 42 · 2013: 42 · 2012: 49
FWCI: 18.34
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
Heart and Stroke Foundation of Canada
Medical Research Council Canada
Medical Research Council
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: hypertriglyceridemic waist phenotype, waist circumference, fasting plasma triglycerides, hyperinsulinemia, apolipoprotein B, small dense LDL, coronary artery disease risk, cardiovascular screening, men
MeSH terms: Abdomen, Adult, Apolipoproteins B, Body Composition, Coronary Artery Disease, Coronary Disease, Humans, Hyperinsulinism, Lipoproteins, LDL, Male, Mass Screening, Middle Aged, Predictive Value of Tests, Risk Factors, Triglycerides, Hypertriglyceridemia, Biomarkers, Coronary Angiography

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Hypertriglyceridemic Waist: A Marker of the Atherogenic Metabolic Triad (Hyperinsulinemia; Hyperapolipoprotein B; Small, Dense LDL) in Men?

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