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Hypertriglyceridemic Waist: A Marker of the Atherogenic Metabolic Triad (Hyperinsulinemia; Hyperapolipoprotein B; Small, Dense LDL) in Men?

Lemieux, Isabelle, Pascot, Agnès, Couillard, Charles, Lamarche, Benoı̂t, Tchernof, André, Alméras, Natalie, Bergeron, Jean, Gaudet, Daniel, Tremblay, Gérald, Prud’homme, Denis, Nadeau, André, Després, Jean-Pierre·2000·Circulation

DOI 10.1161/01.cir.102.2.179

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Abstract

Background —The present study tested the hypothesis that simple variables, such as waist circumference and fasting plasma triglyceride (TG) concentrations, could be used as screening tools for the identification of men characterized by a metabolic triad of nontraditional risk factors (elevated insulin and apolipoprotein [apo] B and small, dense LDL particles). Methods and Results —Results of the metabolic study (study 1) conducted on 185 healthy men indicate that a large proportion (>80%) of men with waist circumference values ≥90 cm and with elevated TG levels (≥2.0 mmol/L) were characterized by the atherogenic metabolic triad. Validation of the model in an angiographic study (study 2) on a sample of 287 men with and without coronary artery disease (CAD) revealed that only men with both elevated waist and TG levels were at increased risk of CAD (odds ratio of 3.6, P <0.03) compared with men with low waist and TG levels. Conclusions —It is suggested that the simultaneous measurement and interpretation of waist circumference and fasting TG could be used as inexpensive screening tools to identify men characterized by the atherogenic metabolic triad (hyperinsulinemia, elevated apo B, small, dense LDL) and at high risk for CAD.

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Influential
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Silva, D. A. R., de Almeida, L. S., Correa, L. L., Pimentel, R., Gomes, A. T., Travassos, A. G., Viana, A. M., Cerqueira, M., de Souza, M. C., de Sousa, A. D., et al. (2021) · doi:10.20944/preprints202111.0554.v1
“It was first described by Lemieux in 2000 [13].”
Background
Metabolic syndrome in patients with Schizophrenia: Relationship with socio-demographic & clinical variables
Kumar, K., Raj, R., & Sattar, F. (2020) · Telangana Journal of Psychiatry · doi:10.18231/j.tjp.2020.007
Hypertriglyceridaemic waist phenotype for Chronic Kidney Disease population: NEFRONA cohort.
Bielsa-Gracia, S., Lou, L. M., Gimeno, J., Gracia-García, O., López-Alejaldre, I., & Fernández, E. (2020) · Nefrología · doi:10.1016/j.nefro.2019.12.005
Hypertriglyceridaemic waist phenotype for Chronic Kidney Disease population: NEFRONA cohort
Bielsa-Gracia, S., Lou, L., Gimeno, J. A., Gracia-García, O., López-Alejaldre, I., & Fernández, E. (2020) · Nefrología (English Edition) · doi:10.1016/j.nefroe.2019.12.007
Prevalence And Factors Associated With Hypertriglyceridemic Waist In Colombian Elderly.Preprint
Rincón-Pabón, D., Urazán-Hernández, Y., Gómez-Rodas, A., & Martínez-Torres, J. (2019) · Research Square · doi:10.21203/rs.2.12972/v1
“Dependent variables The HTGW phenotype was defined as the outcome variable(16), those people who presented with abdominal obesity (the cut points used were abdominal circumference> 80 cm for women and> 90 cm for men (17)) and hypertriglyceridemia (cut-off point used was triglycerides ≥ 150 mg / dl (16)).”
Method
The role of polysaccharide peptides of miselia Ganoderma lucidum extracts on IL-1, IL-6, HSCRP and no in dislipidemic patients with or without hypertension in STEMI and NSTEMI patients
Sargowo, D., Purwanto, E. F., Nugroho, F., Kamila, P., Irawan, D., Sitio, M., Adrian, L., Pratama, A. R., Arifin, Y., Fadlan, M. R., et al. (2019) · INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND NANO-MEDICINE FROM NATURAL RESOURCES FOR BIOMEDICAL RESEARCH: 3rd Annual Scientific Meeting for Biomedical Sciences · doi:10.1063/1.5110002
Identifying and Treating the Metabolic Syndrome
Andrew, C. A. (2018) · Springer eBooks · doi:10.1007/978-3-030-01039-3_1
Efeitos da galantamina sobre biomarcadores inflamatórios e adipocinas em pacientes com síndrome metabólica
Sangaleti, C. T. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2017.tde-19062017-151724
Study of Oxidative Stress Marker Serum Paraoxonase in Metabolic Syndrome
Metab, T. J. E., Rojekar, M., Mogarekar, M., & Adhe-Rojekar, A. (2016) · Endocrinology research and practice. · doi:10.4274/tjem.3586
SCREENING MARKERS; Comparison of BMI, WHpR and lap for identifying hypercholesterolemia, hyperglycemia, hypertension and enhanced atherosclerosis
Khan, S., Bokhari, S. A. R., & Hanif, M. (2016) · The Professional Medical Journal · doi:10.17957/tpmj/16.3400
Hypertriglyceridemic waist in hypertensive patients
Mota, A. P., Machado, M. E. P. D. C., Almeida, M., da Silva, M. D., de Mattos, D. B., Oliveira, T. L., & Medeiros, J. B. (2016) · doi:10.5935/2359-4802.20160036
INDEKS LINGKAR PINGGANG-TRIGLISERIDA PADA REMAJA PUTRI STUNTED OBESITY DI PEDESAAN JEPARA
Sari, P., & Sulchan, M. (2016) · doi:10.14710/jnc.v5i3.16406
“29,30 Trigliserida adalah penyebab utama patogenesis dari aterosklerosis dan merupakan faktor risiko untuk coronary heart disease (CHD).(31) Trigliserida menyebabkan peningkatan LDL dan penurunan HDL-C, dan metabolit lipoprotein tinggi trigliserida yang langsung menyebabkan aterosklerosis.”
Background
JONAFES 2014 - Ciências Exatas, Humanas, Sociais, Biológicas e da Saúde
Claros, J. (2016) · Motricidade · doi:10.6063/motricidade.6978
Hemostatic risk marker associated with cardiovascular events in metabolic syndrome
Bodanese, L., Wiehe, M., Jardim, J., Bonato, C., & Munhoz, E. (2015) · International Journal of Cardiovascular Sciences · doi:10.5935/2359-4802.20150020
Optimal Adiposity Measurement and Risk Stratification in Established Ischaemic Stroke
Lennon, O., & Blake, C. (2014) · World Journal of Cardiovascular Diseases · doi:10.4236/wjcd.2014.413077
Efecto de la administración subcrónica de glucosamina oral en la regulación del peso corporal, glucemia y dislipidemias provocada por una dieta hipercalórica en rata Wistar
Barrientos‐Alvarado, C., Vázquez, J. S., Oscoy, M. A. S. C., Garrido-Acosta, O., & Anguiano‐Robledo, L. (2014) · Revista de Nutrição · doi:10.1590/1415-52732014000600004
Approaches to Reducing Abdominal Obesity
Li, Z.-P., & Heber, D. (2014) · doi:10.1201/b16661-17
Fonction ventilatoire, asthme et facteurs de risque cardiométabolique
Léone, N. (2014) · theses.fr (ABES) · doi:10.70675/47a1f349zed58z4a1cz9119z36e40df00f6e
[Hypertriglyceridemia-increased waist: may we improve the prediction of cardiovascular risk in human immunodeficiency virus infection?].
Vallecillo-Sánchez, G. (2012) · Medicina clínica (Ed. impresa) · doi:10.1016/j.medcli.2012.06.020
Il "Progetto Bagnacavallo": prevalenza dell'ipertransaminasemia e NAFLD nella popolazione generale
Savini, S. (2012) · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna) · doi:10.6092/unibo/amsdottorato/4362
Association Between the Hypertriglyceridemic-Waist Phenotype in Mothers and in Their Offspring
Hirschler, V. (2011) · InTech eBooks · doi:10.5772/22287
Screening for diabetes in a local population of Patan, Nepal
Br, M., Shakya, P., & Bhandary, S. (2010) · Journal of General Practice and Emergency Medicine of Nepal · doi:10.59284/jgpeman202
非糖尿病健常日本人における，肥満と代謝性危険因子との間の年齢別，性別相関関係の特徴：肥満と空腹時血糖との相関は50歳以下では男性よりも女性で強い
小田, 栄., & 隆, 河. (2010) · Ningen dock : official journal of the Japanese Society of Human Dry Dock · doi:10.11320/ningendock.24.1024
Uric Acid Only Among Metabolic Risk Factors Independently Associated with Impaired Fasting Glucose in Apparently Healthy Non-diabetic Japanese Women Older Than 50 Years
Oda, E., & Kawai, R. (2010) · Ningen dock : official journal of the Japanese Society of Human Dry Dock · doi:10.11320/ningendock.24.43
Fat of the matter: inflammation, the waist and cardiovascular risk
Devaraj, S., & Jialal, I. (2009) · Clinical Lipidology · doi:10.2217/clp.09.46
Abdominal Obesity, Metabolic Syndrome, and Risk of Cardiovascular Disease
Marzo, J. (2008) · CRC Press eBooks · doi:10.3109/9781420060850-5
THE RELATIONSHIP BETWEEN SOME ANTHROPOMETRIC INDICES AND THE INCIDENCE OF HYPERTENSION IN STUDENTS OF RIYADH UNIVERSITY FOR WOMEN
AlFaris, N. A. (2008) · Egyptian Journal of Agricultural Sciences /Egyptian Journal of Agricultural Sciences · doi:10.21608/ejarc.2008.217271
Are physicians able to identify high-risk abdominally obese individuals? An analysis from the pan-European Survey of HDL‑cholesterol
Bruckert, E., & Baccara-Dinet, M. (2007) · Current Medical Research and Opinion · doi:10.1185/030079907x225439
“2006 Physicians’ perceptions of obesity © 2007 LiBrApHArM Ltd – Curr Med res Opin 2007; 23(8) obesity and low HDL-cholesterol are included within the diagnostic criteria for the metabolic syndrome according to the US National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATPIII)(10) and the Internation…”
BackgroundMethod
Polycystic ovary syndrome and metabolic syndrome
Hayden, C. J., & Balen, A. H. (2006) · Expert Review of Obstetrics & Gynecology · doi:10.1586/17474108.1.2.183

Authors: Lemieux, I., Pascot, A., Couillard, C., Lamarche, B., Tchernof, A., Alméras, N., Bergeron, J., Gaudet, D., Tremblay, G., Prud’homme, D., Nadeau, A., & Després, J.-P.
Affiliations: Centre hospitalier de l'Université Laval (CA)
From the Quebec Heart Institute, Laval Hospital Research Center; the Lipid Research Center, CHUL Research Center; the Physical Activity Sciences Laboratory, Laval University; the Diabetes Research Unit, CHUL Research Center, Ste-Foy; and the Lipid Clinic, Chicoutimi Hospital, Chicoutimi, Québec, Canada.
ORCID: Lemieux, Isabelle
Couillard, Charles
Lamarche, Benoı̂t
Bergeron, Jean
Gaudet, Daniel
Prud’homme, Denis
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2000-07-11
Volume: 102
Issue: 2
Pages: 179-184
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.102.2.179
OpenAlex: W1991251155
Cited by: 937
References: 0
Citations by year: 2026: 10 · 2025: 19 · 2024: 23 · 2023: 28 · 2022: 31 · 2021: 29 · 2020: 30 · 2019: 26 · 2018: 35 · 2017: 29 · 2016: 38 · 2015: 38 · 2014: 42 · 2013: 42 · 2012: 49
FWCI: 18.34
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
Heart and Stroke Foundation of Canada
Medical Research Council Canada
Medical Research Council
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: hypertriglyceridemic waist phenotype, waist circumference, fasting plasma triglycerides, hyperinsulinemia, apolipoprotein B, small dense LDL, coronary artery disease risk, cardiovascular screening, men
MeSH terms: Abdomen, Adult, Apolipoproteins B, Body Composition, Coronary Artery Disease, Coronary Disease, Humans, Hyperinsulinism, Lipoproteins, LDL, Male, Mass Screening, Middle Aged, Predictive Value of Tests, Risk Factors, Triglycerides, Hypertriglyceridemia, Biomarkers, Coronary Angiography

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Hypertriglyceridemic Waist: A Marker of the Atherogenic Metabolic Triad (Hyperinsulinemia; Hyperapolipoprotein B; Small, Dense LDL) in Men?

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