Cited by 937Diabetes, Cardiovascular Risks, and LipoproteinsLipoproteins and Cardiovascular HealthLipid metabolism and disorders

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Hypertriglyceridemic Waist: A Marker of the Atherogenic Metabolic Triad (Hyperinsulinemia; Hyperapolipoprotein B; Small, Dense LDL) in Men?

Lemieux, Isabelle, Pascot, Agnès, Couillard, Charles, Lamarche, Benoı̂t, Tchernof, André, Alméras, Natalie, Bergeron, Jean, Gaudet, Daniel, Tremblay, Gérald, Prud’homme, Denis, Nadeau, André, Després, Jean-Pierre·2000·Circulation

DOI 10.1161/01.cir.102.2.179

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Abstract

Background —The present study tested the hypothesis that simple variables, such as waist circumference and fasting plasma triglyceride (TG) concentrations, could be used as screening tools for the identification of men characterized by a metabolic triad of nontraditional risk factors (elevated insulin and apolipoprotein [apo] B and small, dense LDL particles). Methods and Results —Results of the metabolic study (study 1) conducted on 185 healthy men indicate that a large proportion (>80%) of men with waist circumference values ≥90 cm and with elevated TG levels (≥2.0 mmol/L) were characterized by the atherogenic metabolic triad. Validation of the model in an angiographic study (study 2) on a sample of 287 men with and without coronary artery disease (CAD) revealed that only men with both elevated waist and TG levels were at increased risk of CAD (odds ratio of 3.6, P <0.03) compared with men with low waist and TG levels. Conclusions —It is suggested that the simultaneous measurement and interpretation of waist circumference and fasting TG could be used as inexpensive screening tools to identify men characterized by the atherogenic metabolic triad (hyperinsulinemia, elevated apo B, small, dense LDL) and at high risk for CAD.

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BackgroundInfluential
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Gene Polymorphisms of FABP2, ADIPOQ and ANP and Risk of Hypertriglyceridemia and Metabolic Syndrome in Afro-Caribbeans
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Metabolic health is more closely associated with prevalence of cardiovascular diseases or stroke than obesity
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“A previous study mentioned the “hypertriglyceridemic waist,” which means a phenotypewho had an excessive visceral adipose tissue, increased waist circumference, and elevated plasma triglyceride levels.([26]) Another study also suggested that the percentage of visceral adipose tissue has to be regarded as a risk factor…”
Prevention of Atherosclerotic Cardiovascular Disease
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Hypertriglyceridemic waist and newly-diagnosed diabetes among remote-dwelling Indigenous Australians
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Predicting cardiovascular risk using measures of regional and total body fat.
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One third of the variability in HDL‐cholesterol level in a large dyslipidaemic population is predicted by age, sex and triglyceridaemia:The Paris La Pitié Study
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The association of hypertriglyceridemic waist phenotype with hypertension: A cross‐sectional study in a Chinese middle aged‐old population
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Vascular and metabolic profiles in offspring born to pregnant mice with metabolic syndrome treated with inositols
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A prospective study of the hypertriglyceridemic waist phenotype and risk of incident ischemic stroke in a Chinese rural population
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Hypertriglyceridemic Waist Phenotype Indicates Insulin Resistance in Adolescents According to the Clamp Technique in the BRAMS Study
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A Comparative Study of Lipid-Lowering Effects of Guggul and Atorvastatin Monotherapy in Comparison to Their Combination in High Cholesterol Diet-Induced Hyperlipidemia in Rabbits
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“A triad hyperinsulinemia, increased levels of apo B and small dense LDL particles can increase the risk of cardiovascular disease by up to 20 times (Lemieux et al., 2000).”
Background
Waist Circumference as a Vital Sign in Cardiology 20 Years After Its Initial Publication in The American Journal of Cardiology
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The concomitant use of second-generation antipsychotics and long-term antiretroviral therapy may be associated with increased cardiovascular risk
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“…triglycerides and DM. Additionally, TC and TG values were also analyzed on a dichotomized scale based on the most recent guidelines for risk ranges: TC ≥ 200 mg/dL, HDL < 40 mg/dL, LDL ≥ 130 mg/dL, TC/HDL ≥ 5, TG ≥ 150 mg/dL (Blackburn et al., 2008; Lemieux et al., 2000; Mannucci et al., 2008).”
Method
A Review on Underlying Differences in the Prevalence of Metabolic Syndrome in the Middle East, Europe and North America
Ahmadpour, F. (2014) · Journal of Molecular and Genetic Medicine · doi:10.4172/1747-0862.s1-019 · Cited by 12
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BackgroundInfluential
Prevalence of Hyperapolipoprotein B and Associations with Other Cardiovascular Risk Factors Among Human Immunodeficiency Virus–Infected Patients in Pernambuco, Brazil
de Carvalho, É. H., Miranda-Filho, D. D. B., Ximenes, R. A. D. A., de Albuquerque, M. D. F. P. M., Lacerda, H. R., Gelenske, T., Barros, Z. D. M., Montarroyos, U. R., & Bandeira, F. A. F. (2010) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2009.0092 · Cited by 12
Waist circumference has heterogeneous impact on development of diabetes in different populations: longitudinal comparative study between Australia and Iran.
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Prevalencia del síndrome metabólico en la población adulta de Yecla (Murcia). Grado de acuerdo entre tres definiciones
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Obésité et maladies cardiovasculaires
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Exercise and Bone Health
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BackgroundInfluential
Optimum non-invasive predictive indicators for metabolic dysfunction-associated fatty liver disease and its subgroups in the Chinese population: A retrospective case-control study
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BackgroundMethod
Genetic Determinants of Risk Factors for Cardiovascular Disease in a Population from Rural Brazil
Velásquez-Meléndez, G., Parra, F. C., Gazzinelli, A., Williams‐Blangero, S., & Corrêa‐Oliveira, R. (2007) · Human Biology · doi:10.1353/hub.2007.0036 · Cited by 9
“For example, amount of abdominal fat tissue, dietary intake, and level of physical activity have all been shown to influence lipoprotein levels (Després et al. 1990; Lemieux et al. 2000).”
Background

Authors: Lemieux, I., Pascot, A., Couillard, C., Lamarche, B., Tchernof, A., Alméras, N., Bergeron, J., Gaudet, D., Tremblay, G., Prud’homme, D., Nadeau, A., & Després, J.-P.
Affiliations: Centre hospitalier de l'Université Laval (CA)
From the Quebec Heart Institute, Laval Hospital Research Center; the Lipid Research Center, CHUL Research Center; the Physical Activity Sciences Laboratory, Laval University; the Diabetes Research Unit, CHUL Research Center, Ste-Foy; and the Lipid Clinic, Chicoutimi Hospital, Chicoutimi, Québec, Canada.
ORCID: Lemieux, Isabelle
Couillard, Charles
Lamarche, Benoı̂t
Bergeron, Jean
Gaudet, Daniel
Prud’homme, Denis
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2000-07-11
Volume: 102
Issue: 2
Pages: 179-184
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.102.2.179
OpenAlex: W1991251155
Cited by: 937
References: 0
Citations by year: 2026: 10 · 2025: 19 · 2024: 23 · 2023: 28 · 2022: 31 · 2021: 29 · 2020: 30 · 2019: 26 · 2018: 35 · 2017: 29 · 2016: 38 · 2015: 38 · 2014: 42 · 2013: 42 · 2012: 49
FWCI: 18.34
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
Heart and Stroke Foundation of Canada
Medical Research Council Canada
Medical Research Council
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: hypertriglyceridemic waist phenotype, waist circumference, fasting plasma triglycerides, hyperinsulinemia, apolipoprotein B, small dense LDL, coronary artery disease risk, cardiovascular screening, men
MeSH terms: Abdomen, Adult, Apolipoproteins B, Body Composition, Coronary Artery Disease, Coronary Disease, Humans, Hyperinsulinism, Lipoproteins, LDL, Male, Mass Screening, Middle Aged, Predictive Value of Tests, Risk Factors, Triglycerides, Hypertriglyceridemia, Biomarkers, Coronary Angiography

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Hypertriglyceridemic Waist: A Marker of the Atherogenic Metabolic Triad (Hyperinsulinemia; Hyperapolipoprotein B; Small, Dense LDL) in Men?

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