Cited by 1,089Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesGastrointestinal motility and disorders

The intestinal microbiota fuelling metabolic inflammation

Tilg, Herbert, Zmora, Niv, Adolph, Timon E., Elinav, Eran·2020·Nature Reviews Immunology

Abstract

Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2 diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these disorders are characterized by alterations in the intestinal microbiota composition and its metabolites, which translocate from the gut across a disrupted intestinal barrier to affect various metabolic organs, such as the liver and adipose tissue, thereby contributing to metabolic inflammation. Here, we discuss some of the recently identified mechanisms that showcase the role of the intestinal microbiota and barrier dysfunction in metabolic inflammation. We propose a concept by which the gut microbiota fuels metabolic inflammation and dysregulation.

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Crossref · 10.1038/s41577-019-0198-4

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267 of 267 references verified0 citation errors · 0 not checkable

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  • Gut microbiome-derived metabolites can reach systemic circulation through the gut barrier and fuel metabolic inflammation.

    “Growing evidence shows that gut microbiome-derived metabolites can reach systemic circulation through the gut barrier and fuel metabolic inflammation.179”

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Authors
Tilg, H., Zmora, N., Adolph, T. E., & Elinav, E.
Affiliations
  • Innsbruck Medical University (AT)
  • Tel Aviv Sourasky Medical Center (IL)
  • German Cancer Research Center (DE)
Corresponding author
  • Tilg, Herbert
  • Elinav, Eran
Venue
Nature Reviews Immunology
Published
2019-08-06
Volume
20
Issue
1
Pages
40-54
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W2965140029
Cited by
1,089
References
267
Citations by year
2026: 149 · 2025: 152 · 2024: 169 · 2023: 162 · 2022: 184 · 2021: 171 · 2020: 88 · 2019: 12 · 2017: 1
FWCI
10.31
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
gut microbiota, metabolic inflammation, low-grade inflammation, obesity, type 2 diabetes, non-alcoholic fatty liver disease, intestinal barrier dysfunction, microbial metabolites, adipose tissue, liver
MeSH terms
Gastrointestinal Microbiome, Animals, Chronic Disease, Humans, Inflammation, Intestinal Mucosa, Metabolic Diseases, Dysbiosis

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