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Cited by 595Fatty Acid Research and HealthLipoproteins and Cardiovascular HealthNutritional Studies and Diet

The DOI matches its Crossref record.

A Controlled Clinical Trial of a Diet High in Unsaturated Fat in Preventing Complications of Atherosclerosis

DAYTON, SEYMOUR, PEARCE, MORTON LEE, HASHIMOTO, SAM, DIXON, WILFRID J., TOMIYASU, UWAMIE·1969·Circulation
DOI 10.1161/01.cir.40.1s2.ii-1
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Abstract

This report describes a clinical trial, with domiciled male veterans, designed to determine whether a diet which lowers serum cholesterol concentration can prevent overt complications of coronary heart disease and other manifestations of atherosclerosis. Volunteers were allocated randomly to control and experimental groups. Participants numbered 422 in the control group and 424 in the experimental group. The two groups were indistinguishable at the outset of the study in almost all observations. These included age, racial characteristics, and religious affiliation; height, weight, and blood pressure; electrocardiographic findings; prevalence of pre-existing anginal syndrome, myocardial infarction, peripheral atherosclerosis, cerebral ischemia, or cerebral infarction; cardiac decompensation; utilization of relevant medications; serum cholesterol and serum total lipid levels; and prevalence of corneal arcus and xanthelasma. One significant difference between the groups in regard to a possibly influential characteristic was that they differed slightly in patterns of cigarette smoking habits. The control diet was similar to the regular institutional diet, which is a standard American diet. It provided, by analysis, 40.1% of calories as fat, having a mean iodine value of 53.5; cholesterol intake was 262 mg/1,000 calories (653 mg/day). The experimental diet provided 38.9% of calories as fat, with an iodine value of 102.4, and had a cholesterol content of 146 mg/1,000 calories (365…

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Metadata

Authors
DAYTON, S., PEARCE, M. L., HASHIMOTO, S., DIXON, W. J., & TOMIYASU, U.
Affiliations
United States Department of Veterans Affairs (US)
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1969-07
Volume
40
Issue
1s2
Pages
1237-42
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.40.1s2.ii-1
OpenAlex
W1991289303
Cited by
595
References
0
Citations by year
2026: 3 · 2025: 2 · 2024: 9 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 11 · 2017: 9 · 2016: 7 · 2015: 9 · 2014: 3 · 2013: 6 · 2012: 8
FWCI
15.88
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
dietary fat, serum cholesterol, atherosclerosis, coronary artery disease, linoleic acid, dietary cholesterol, dietary adherence, dietary fat saturation, adipose tissue fatty acid composition, veterans, dietary intervention, cholesterol-lowering diet
MeSH terms
Aged, Cerebrovascular Disorders, Cholesterol, Clinical Trials as Topic, Coronary Disease, Dietary Fats, Fats, Unsaturated, Humans, Male, Middle Aged

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