Cited by 595Fatty Acid Research and HealthLipoproteins and Cardiovascular HealthNutritional Studies and Diet

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A Controlled Clinical Trial of a Diet High in Unsaturated Fat in Preventing Complications of Atherosclerosis

DAYTON, SEYMOUR, PEARCE, MORTON LEE, HASHIMOTO, SAM, DIXON, WILFRID J., TOMIYASU, UWAMIE·1969·Circulation

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Abstract

This report describes a clinical trial, with domiciled male veterans, designed to determine whether a diet which lowers serum cholesterol concentration can prevent overt complications of coronary heart disease and other manifestations of atherosclerosis. Volunteers were allocated randomly to control and experimental groups. Participants numbered 422 in the control group and 424 in the experimental group. The two groups were indistinguishable at the outset of the study in almost all observations. These included age, racial characteristics, and religious affiliation; height, weight, and blood pressure; electrocardiographic findings; prevalence of pre-existing anginal syndrome, myocardial infarction, peripheral atherosclerosis, cerebral ischemia, or cerebral infarction; cardiac decompensation; utilization of relevant medications; serum cholesterol and serum total lipid levels; and prevalence of corneal arcus and xanthelasma. One significant difference between the groups in regard to a possibly influential characteristic was that they differed slightly in patterns of cigarette smoking habits. The control diet was similar to the regular institutional diet, which is a standard American diet. It provided, by analysis, 40.1% of calories as fat, having a mean iodine value of 53.5; cholesterol intake was 262 mg/1,000 calories (653 mg/day). The experimental diet provided 38.9% of calories as fat, with an iodine value of 102.4, and had a cholesterol content of 146 mg/1,000 calories (365…

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Authors: DAYTON, S., PEARCE, M. L., HASHIMOTO, S., DIXON, W. J., & TOMIYASU, U.
Affiliations: United States Department of Veterans Affairs (US)
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1969-07
Volume: 40
Issue: 1s2
Pages: 1237-42
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.40.1s2.ii-1
OpenAlex: W1991289303
Cited by: 595
References: 0
Citations by year: 2026: 3 · 2025: 2 · 2024: 9 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 11 · 2017: 9 · 2016: 7 · 2015: 9 · 2014: 3 · 2013: 6 · 2012: 8
FWCI: 15.88
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: dietary fat, serum cholesterol, atherosclerosis, coronary artery disease, linoleic acid, dietary cholesterol, dietary adherence, dietary fat saturation, adipose tissue fatty acid composition, veterans, dietary intervention, cholesterol-lowering diet
MeSH terms: Aged, Cerebrovascular Disorders, Cholesterol, Clinical Trials as Topic, Coronary Disease, Dietary Fats, Fats, Unsaturated, Humans, Male, Middle Aged

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A Controlled Clinical Trial of a Diet High in Unsaturated Fat in Preventing Complications of Atherosclerosis

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