The DOI matches its Crossref record.
A Controlled Clinical Trial of a Diet High in Unsaturated Fat in Preventing Complications of Atherosclerosis
Abstract
This report describes a clinical trial, with domiciled male veterans, designed to determine whether a diet which lowers serum cholesterol concentration can prevent overt complications of coronary heart disease and other manifestations of atherosclerosis. Volunteers were allocated randomly to control and experimental groups. Participants numbered 422 in the control group and 424 in the experimental group. The two groups were indistinguishable at the outset of the study in almost all observations. These included age, racial characteristics, and religious affiliation; height, weight, and blood pressure; electrocardiographic findings; prevalence of pre-existing anginal syndrome, myocardial infarction, peripheral atherosclerosis, cerebral ischemia, or cerebral infarction; cardiac decompensation; utilization of relevant medications; serum cholesterol and serum total lipid levels; and prevalence of corneal arcus and xanthelasma. One significant difference between the groups in regard to a possibly influential characteristic was that they differed slightly in patterns of cigarette smoking habits. The control diet was similar to the regular institutional diet, which is a standard American diet. It provided, by analysis, 40.1% of calories as fat, having a mean iodine value of 53.5; cholesterol intake was 262 mg/1,000 calories (653 mg/day). The experimental diet provided 38.9% of calories as fat, with an iodine value of 102.4, and had a cholesterol content of 146 mg/1,000 calories (365…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Five studies were conducted in European countries (15), (18), (19), (21), (23), 2 in the USA (20), (22), 1 in Australia (24), and 1 in India (25).”
From Saturated Fat Restriction for Cardiovascular Disease Prevention: A Systematic Review and Meta-analysis of Randomized Controlled Trials (2025) · cites this paper as [20]
In the citing paper
“Only 2 studies were primary prevention trials from the USA (20), (22); the remaining 7 were secondary prevention trials.”
From Saturated Fat Restriction for Cardiovascular Disease Prevention: A Systematic Review and Meta-analysis of Randomized Controlled Trials (2025) · cites this paper as [20]
In the citing paper
“Only 3 studies were on stroke (20), (23), (25), and the incidence of stroke was almost zero in 2 of those studies (23), (25).”
From Saturated Fat Restriction for Cardiovascular Disease Prevention: A Systematic Review and Meta-analysis of Randomized Controlled Trials (2025) · cites this paper as [20]
In the citing paper
“Although we did not observe statistically significant CVD prevention due to SFA reduction, several studies included in our meta-analysis reported positive results with SFA reduction (15), (19), (20), (23).”
From Saturated Fat Restriction for Cardiovascular Disease Prevention: A Systematic Review and Meta-analysis of Randomized Controlled Trials (2025) · cites this paper as [20]
In the citing paper
“Furthermore, in previous studies showing positive outcomes (15), (19), (20), (23), statins were not prescribed to the participants.”
From Saturated Fat Restriction for Cardiovascular Disease Prevention: A Systematic Review and Meta-analysis of Randomized Controlled Trials (2025) · cites this paper as [20]
In the citing paper
“Specifically, each 1-mmol/L reduction in LDL-C was associated with an RR of 0.75 (95% CI, 0.66-0.86;P = .002)in major vascular events”
From Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis (2016) · cites this paper as [49]
Citations
Cited by
Sorted by citations
Items 501–543 of 543
Meade, T. (1973) · doi:10.1177/003591577306600721
Experimental trials and literature review: Cholesterol-lowering diets1
Anderson, J., Grande, F., & Keys, A. (1973) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(21)08792-7
Developing a program of learning on the fat-controlled diet.
Pye, O. F., Brooks, C. G., & Winston, M. M. (1970) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(21)13557-6
Die medizinische Behandlung der koronaren Herzkrankheit
Schweizer, W. (1969) · doi:10.1055/s-0028-1110499
Nutrition and Coronary Heart Disease Prevention
Schaefer, E. J., & Tani, M. (2015) · Contemporary Endocrinology · doi:10.1007/978-1-60761-424-1_19
Cholesterol Reduction and Coronary Artery Disease
Tikkanen, M., & Pyörälä, K. (2012) · Drugs · doi:10.2165/00003495-198800363-00008
“The Los Angeles Veterans Administration Study (Dayton et al. 1969)was a randomised double-blind trial carried out in 846 middle-aged and elderly men (median age 65.”
MethodCholesterol Management and Risk Reduction – Current Guidelines and Barriers to Goal Attainment
Holt, G., Wong, P., & Writer, T. B. M. (2008) · Asia Pacific Cardiology · doi:10.15420/apc.2008:2:1:16
Cardiovascular Disease and Lifestyle Modification
Sacks, F. M., & McManus, K. (2007) · Elsevier eBooks · doi:10.1016/b978-1-4160-3358-5.50034-6 · Cited by 1
Facteurs diététiques et cardiopathies coronariennes
Masironi, R. (2005) · Zeitschrift für Präventivmedizin · doi:10.1007/bf02030462
Faxon, D., Ruocco, N., & Jacobs, A. K. (2005) · doi:10.1007/978-3-540-35280-8_656
Hypolipémiants et prévention des accidents vasculaires cérébraux. Méta-analyse
Corvol, J., Bouzamondo, A., Sirol, M., Hulot, J., Sanchez, P., & Lechat, P. (2003) · Therapies · doi:10.2515/therapie:2003006
Approach to the Patient with Hyperlipidemia
Stone, N. J. (2001) · doi:10.1007/978-1-4615-6601-4_14
Perspectives on Lipid-Lowering Therapy: Past and Present
Gotto, A. M. (1998) · Medical science symposia series · doi:10.1007/978-94-011-5022-4_4
When and How to Treat Hypercholesterolemia in the Elderly
Capurso, A., & Capurso, S. (1998) · doi:10.1007/978-1-4899-1483-5_24
Effets indésirables et interactions médicamenteuses des hypolipémiants
Lamrini, R., Vial, T., Payen, C., & Evreux, J. (1997) · Lyon Pharmaceutique · doi:10.1016/s0024-7804(97)85033-6
Primary Prevention of Colorectal Tumors
Kune, G. A. (1996) · Springer eBooks · doi:10.1007/978-1-4613-1273-4_18
Epidemiologie und Prävention der koronaren Herzkrankheit
Weisswange, A. (1996) · doi:10.1007/978-3-642-97605-6_28
Blankenhorn, D. H., & Hodis, H. N. (1994) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-78426-2_8
Richter, W. O. (1994) · Fette Seifen Anstrichmittel · doi:10.1002/lipi.19940960104
Ernährung und Atheroskleroseprävention
Richter, W. O., & SCHWANDT, P. (1993) · Springer eBooks · doi:10.1007/978-3-662-08215-7_16
Therapie der Koronaren Herzkrankheit
Kupper, W. (1993) · doi:10.1007/978-3-642-77483-6_6
Rees, A., Lavie, C., & Pepine, C. (1993) · Developments in cardiovascular medicine · doi:10.1007/978-1-4615-3516-4_12
Cardiovascular Risk Factors in Older Individuals
Crepaldi, G., Maggi, S., & Baggio, G. (1992) · doi:10.1007/978-94-011-2700-4_6
Oliver, M. (1991) · Springer eBooks · doi:10.1007/978-1-4471-1889-3_13
Risk Factors for Coronary Artery Disease and Atherothrombotic Brain Infarction in the Elderly
Aronow, W. S. (1988) · Springer eBooks · doi:10.1007/978-1-4684-5427-7_9
Lipid-Lowering Drugs in the Treatment of Atherosclerosis
Hunninghake, D., & Peters, J. (1987) · doi:10.1007/978-1-4684-5296-9_45
Oliver, M. F. (1985) · Springer eBooks · doi:10.1007/978-1-4613-2459-1_18
Primary and secondary prevention of coronary artery disease by drug therapy
Baber, N. (1985) · Springer eBooks · doi:10.1007/978-94-009-4876-1_3
The Role of Manipulating Lipids in Uremia
Golper, T. (1985) · Springer eBooks · doi:10.1007/978-1-4684-4826-9_25
A Behavioral Approach to Prevention of Coronary Heart Disease
Patel, C. (1985) · Springer eBooks · doi:10.1007/978-94-009-5179-2_14
Nutritional Modification for Prevention and Treatment of Hyperlipidemia and Hyperlipoproteinemia
Naito, H. (1982) · Springer eBooks · doi:10.1007/978-94-011-6692-8_12
The major intervention studies
Brisson, G. (1981) · Springer eBooks · doi:10.1007/978-94-015-7212-5_7
Is Risk Factor Intervention Worthwhile
Simons, L., & Gibson, J. (1980) · doi:10.1007/978-94-010-9464-1_3
Möglichkeiten der Prävention bei der koronaren Herzkrankheit
Kaffarnik, H., & Schneider, J. (1980) · doi:10.1007/978-3-642-67699-4_9
Patientization of the Population
Taylor, R. (1979) · doi:10.1007/978-1-349-05776-4_8
Experimental Production of Atherosclerosis: Nutritional Influences
Heyden, S. (1975) · Springer eBooks · doi:10.1007/978-3-642-45467-7_3
Metadata
- Authors
- DAYTON, S., PEARCE, M. L., HASHIMOTO, S., DIXON, W. J., & TOMIYASU, U.
- Affiliations
- United States Department of Veterans Affairs (US)
- Venue
- Circulation
- Published
- 1969-07
- Volume
- 40
- Issue
- 1s2
- Pages
- 1237-42
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1991289303
- Cited by
- 595
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 9 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 11 · 2017: 9 · 2016: 7 · 2015: 9 · 2014: 3 · 2013: 6 · 2012: 8
- FWCI
- 15.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- dietary fat, serum cholesterol, atherosclerosis, coronary artery disease, linoleic acid, dietary cholesterol, dietary adherence, dietary fat saturation, adipose tissue fatty acid composition, veterans, dietary intervention, cholesterol-lowering diet
- MeSH terms
- Aged, Cerebrovascular Disorders, Cholesterol, Clinical Trials as Topic, Coronary Disease, Dietary Fats, Fats, Unsaturated, Humans, Male, Middle Aged
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
