The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Determinants of ventricular function in pressure-overload hypertrophy in man.
Open accessAbstract
To test the hypothesis that impaired cardiac performance in some patients with pressure- overload hypertrophy is due to inappropriately high wall stress, rather than depressed contractility, the importance of hemodynamic and geometric factors was assessed in 14 patients with isolated aortic stenosis and vari- ous degrees of left ventricular failure (ejection fraction range 0.19-0.85).There was poor correlation between either aortic valve area, peak left ventricular systolic pressure, or left ventricular mass, and measures of ventricular function.In contrast, there were close correlations between circumferential wall stress and both ejection fraction (r= 0.96) and velocity of fiber shortening (r = 0.91) in patients with aortic stenosis.Force- velocity-shortening relationships in six normal control subjects fell on the same regression line as that defined by the patients with aortic stenosis, while force-velocity-shortening relationships of patients with primary myocardial failure clearly differed.A major determinant of wall stress was the ratio of left ventricular wall thickness to cavity radius (h/R).Patients with h/R ratios > 0.36 had higher values for ejection fraction (0.61 ± 0.06 vs 0.36 i 0.07,p < 0.05), Vcf (0.79 ± 0.10 vs 0.39 ± 0.04 sec ',p < 0.05) and stroke work in- dex (71 ± 10 vs 45 9 g-m/m2, p < 0.005) than those with lower ratios.The results indicate that left ventricular wall thickness and geometry are closely correlated with ventricular performance in patients with pressure-overload hypertrophy due to aortic stenosis.Poor cardiac performance in some such patients may be due to inadequate hypertrophy (or inappropriate geometry) rather than to depression of myocardial contractility.MYOCARDIAL FUNCTION in pressure-overload hypertrophy is a controversial subject.It is generally agreed that the development of hypertrophy in response to a pressure overload is associated at least initially with wall thickening commensurate with the
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Citations
Cites
Wall stress and patterns of hypertrophy in the human left ventricle.
Grossman, W., Jones, D., & McLaurin, L. P. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108079 · Cited by 2,403
Self-citation
Cited by
Left Ventricular Hypertrophy: Pathogenesis, Detection, and Prognosis
Lorell, B. H., & Carabello, B. A. (2000) · Circulation · doi:10.1161/01.cir.102.4.470 · Cited by 1,232
Carabello, B. A., & Paulus, W. J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60211-7 · Cited by 818
Dweck, M. R., Boon, N. A., & Newby, D. E. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.02.093 · Cited by 692
Sex-associated differences in left ventricular function in aortic stenosis of the elderly.
Carroll, J. D., Carroll, E. P., Feldman, T., Ward, D. M., Lang, R. M., McGaughey, D., & Karp, R. B. (1992) · Circulation · doi:10.1161/01.cir.86.4.1099 · Cited by 488
Aurigemma, G. P., Silver, K. H., Priest, M. A., & Gaasch, W. H. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00153-q · Cited by 399
Metadata
- Authors
- Gunther, S., & Grossman, W.
- Venue
- Circulation
- Published
- 1979-04
- Volume
- 59
- Issue
- 4
- Pages
- 679-688
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2021027916
- Cited by
- 350
- References
- 1
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
