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Cited by 201Blood Pressure and Hypertension StudiesCardiovascular Function and Risk FactorsRenin-Angiotensin System Studies

Borderline hypertension and obesity: two prehypertensive states with elevated cardiac output

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Messerli, F H, Ventura, H O, Reisin, E, Dreslinski, G R, Dunn, F G, MacPhee, A A, Frohlich, E D·1982·Circulation
DOI 10.1161/01.cir.66.1.55
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Abstract

Systemic, renal and splanchnic hemodynamics, intravascular volume, circulating catecholamine levels and plasma renin activity were compared in 39 patients with borderline hypertension and 28 normotensive subjects, who were less than 5% (n = 42, lean patients) or more than 40% overweight (n = 25, obese patients). Lean borderline hypertensive patients had greater cardiac output (p less than 0.05), heart rate (p less than 0.01) and renal blood flow (p less than 0.05); cardiopulmonary redistribution of intravascular volume (p less than 0.05); and higher circulating norepinephrine levels (p less than 0.05). Obese normotensive subjects also showed an increased cardiac output (p less than 0.005), stroke volume (p less than 0.01), left ventricular stroke work (p less than 0.05), and renal blood flow (p less than 0.05) (but not respective indexes), but intravascular volume was expanded (p less than 0.05) without redistribution and circulating catecholamine levels were normal. Obese borderline hypertensive patients had hemodynamic characteristics similar to those of obese normotensive subjects except for an increased peripheral resistance (p less than 0.05). The data indicate that although both populations have an increased cardiac output, the lean borderline hypertensive patients have signs of enhanced adrenergic activity as evidenced by higher circulating catecholamine levels and heart rate with blood volume translocation to the cardiopulmonary circulation. In contrast, the obese subjects (whether normotensive or borderline hypertensive), who also have increased cardiac output, seem to have normal adrenergic activity and an expanded intravascular volume without cardiopulmonary redistribution.

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  • Obese patients typically have higher cardiac output but lower total peripheral resistance at any given arterial pressure.

    “Typically, obese patients have a higher cardiac output but a lower level of total peripheral resistance at any given level of arterial pressure (14,15).”

    From Obesity and Cardiovascular Disease (2009) · cites this paper as [15]

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Research works printed but not linked: 3

  1. Julius S: Borderline hypertension: epidemiologic and clinical manifestations. In Hypertension: Physiopathology and Treatment, edited by Genest J, Koiw E, Kuchel 0. New York, McGraw-Hill, 1977, p 630
  2. Frohlich ED: Hemodynamics in hypertension. In Hypertension: Physiopathology and Treatment, edited by Genest J, Koiw E, Kuchel 0. New York, McGraw-Hill, 1977, p 15
  3. New Weight Standards for Men and Women. Statistical Bulletin, Metropolitan Life Insurance Company 40: 1, 1959

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Authors
Messerli, F. H., Ventura, H. O., Reisin, E., Dreslinski, G. R., Dunn, F. G., MacPhee, A. A., & Frohlich, E. D.
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1982-07
Volume
66
Issue
1
Pages
55-60
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.66.1.55
OpenAlex
W2033757938
Cited by
201
References
20
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 4 · 2016: 8 · 2015: 6 · 2014: 4 · 2013: 8 · 2012: 4
FWCI
6.88
Type
journal article
Language
en
Open access
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (HL-22506)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords
borderline hypertension, obesity, prehypertension, cardiac output, hemodynamics, renal blood flow, catecholamines, norepinephrine, plasma renin activity, systemic vascular resistance, heart rate, stroke volume, left ventricular stroke work
MeSH terms
Adult, Blood Volume, Body Weight, Cardiac Output, Female, Heart Rate, Humans, Hypertension, Male, Middle Aged, Obesity, Renal Circulation, Stroke Volume

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