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Cited by 141Blood Pressure and Hypertension StudiesDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Function and Risk Factors

Is hypertension more benign when associated with obesity?

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Barrett-Connor, E, Khaw, K T·1985·Circulation
DOI 10.1161/01.cir.72.1.53
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Abstract

To determine the effect of obesity on prognosis in hypertensive subjects, a population of 1727 men 50 to 79 years of age was dichotomized by baseline body mass index (less than 27 and greater than or equal to 27 kg/m2) and systolic blood pressure (less than 160 and greater than or equal to 160 mm Hg). After 9 years of follow-up, age-adjusted all-cause, cardiovascular, and ischemic heart disease mortality rates were highest in the nonobese hypertensive subjects. The relative risk for mortality associated with a systolic blood pressure of 160 mm Hg or higher was significantly increased only in the nonobese group, with the largest difference in relative risk between obese and nonobese for ischemic heart disease. Results were consistent after separately excluding those with a history of heart disease, diabetes, current use of antihypertensive medication, and cigarette smoking, and those who died within 2 years of the baseline examination. When the independent effect of risk factors, including age, plasma cholesterol level, cigarette smoking, use of antihypertensive medication, and personal history of heart disease or diabetes was assessed with the Cox model, systolic blood pressure was a significant independent predictor of all-cause, cardiovascular, and ischemic heart disease death only in the nonobese subjects. We do not exclude an adverse effect of raised blood pressure in the obese. However, these data suggest that the prognosis is poorer in leaner hypertensive patients than in those who are overweight.

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  • In the index study of 1727 men aged 50 to 79 years, age-adjusted all-cause and ischemic heart disease mortality was reduced in overweight and obese men, and this finding remained when those with a history of cigarette smoking were excluded.

    “In this index study on 1727 men aged 50 to 79 years, age-adjusted all-cause and ischemic heart disease mortality was reduced in overweight and obese men, a finding which remained when those with a history of cigarette smoking were excluded.”

    From Obesity Paradox in Hypertension: Is This Because Sympathetic Activation in Obesity-Hypertension Takes a Benign Form? (2018) · cites this paper as [14]

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Research works printed but not linked: 1

  1. Kannel WB, Gordon T: Some determinants of obesity and its im- pact as a cardiovascular disease risk factor. In Howard A, editor: Recent advances in obesity research. 1. Obesity. Proceedings of the 1st International Congress, Royal College of Physicians, London, England, October 1974. Technomic Publishing Co.. Westport, CT, 1976, pp 14-27

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Authors
Barrett-Connor, E., & Khaw, K. T.
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1985-07
Volume
72
Issue
1
Pages
53-60
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.72.1.53
OpenAlex
W2036808878
Cited by
141
References
30
Citations by year
2023: 2 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 3 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 4
FWCI
10.12
Type
journal article
Language
en
Open access
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (NHLBI-HV-1-2160-L, NIH-NHLBI-HV-1-2160-L, HV-1-2160-L)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
hypertension, obesity, body mass index, systolic blood pressure, mortality, cardiovascular mortality, ischemic heart disease, all-cause mortality, prognosis, middle-aged and older men, cardiovascular risk factors
MeSH terms
Aged, Coronary Disease, Humans, Hypertension, Male, Middle Aged, Obesity, Risk

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