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Cited by 245Cardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityDiabetes, Cardiovascular Risks, and Lipoproteins

Obesity and the Heart

Alpert, Martin A., Hashimi, M. Wail·1993·The American Journal of the Medical Sciences
DOI 10.1097/00000441-199308000-00011
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Abstract

Obesity can result in alterations in cardiac structure and function even in the absence of systemic hypertension and underlying organic heart disease. Increased total blood volume creates a high cardiac output state that may cause ventricular dilatation and ultimately eccentric hypertrophy of the left (and possibly the right) ventricle. Eccentric left ventricular (LV) hypertrophy produces diastolic dysfunction. Systolic dysfunction may ensue due to excessive wall stress if wall thickening fails to keep pace with dilatation. This disorder is referred to as obesity cardiomyopathy. The presence of systemic hypertension in obese individuals facilitates development of LV dilatation and hypertrophy. Congestive heart failure may occur in such individuals, and may be attributable to LV diastolic dysfunction or to combined LV diastolic and systolic dysfunction. The sleep apnea/obesity hypoventilation syndrome occurs in 5% of morbidly obese individuals and is potentially life-threatening. Treatment of obesity cardiomyopathy consists of weight loss, salt restriction, and diuretics. Digitalis and vasodilators may be useful in selected cases. Central obesity is probably a risk factor for the development of coronary heart disease. Alterations in lipid and insulin metabolism may facilitate development of coronary heart disease in obese patients.

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Crossref · 10.1097/00000441-199308000-00011

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78 of 78 references verified0 citation errors · 0 not checkable

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  • Stroke volume and cardiac output are both increased in obese individuals.

    “In addition, stroke volume and cardiac output are both increased (13, 49, 165, 170, 284).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [13]

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Authors
Alpert, M. A., & Hashimi, M. W.
Affiliations
University of South Alabama Medical Center (US)
Corresponding author
Alpert, Martin A.
ORCID
Alpert, Martin A.
Venue
The American Journal of the Medical Sciences
Publisher
Elsevier BV
Published
1993-08
Volume
306
Issue
2
Pages
117-123
ISSN
0002-9629 (ISSN-L)
DOI
10.1097/00000441-199308000-00011
OpenAlex
W2015366001
Cited by
245
References
78
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 6 · 2022: 4 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 5 · 2014: 7 · 2013: 8 · 2012: 8
FWCI
1.66
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of the Medical Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
obesity, obesity cardiomyopathy, left ventricular hypertrophy, left ventricular dilatation, diastolic dysfunction, systolic dysfunction, systemic hypertension, congestive heart failure, sleep apnea, obesity hypoventilation syndrome, weight loss, salt restriction, diuretics, digitalis, vasodilators, abdominal obesity, coronary artery disease, insulin metabolism, lipid metabolism
MeSH terms
Heart Diseases, Humans, Obesity, Obesity, Morbid, Obesity Hypoventilation Syndrome

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