The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Reduction of the size of infarction by allopurinol in the ischemic-reperfused canine heart.
Open accessAbstract
This study was performed to assess the effect of allopurinol in a canine preparation of myocardial infarction. Dogs underwent occlusion of the left circumflex coronary artery for 90 min, followed by reperfusion for 6 hr. Three groups were studied: (1) control, (2) dogs receiving 25 mg/kg allopurinol 18 hr before occlusion and 50 mg/kg 5 min before occlusion, and (3) dogs receiving allopurinol as above plus 5 mg/kg superoxide dismutase over 1 hr beginning 15 min before reperfusion. Infarct size expressed as a percentage of the area at risk was 40 +/- 4 in the control group, 22 +/- 5 in the allopurinol group (p less than .05 vs control), and 17 +/- 4 in the allopurinol plus superoxide dismutase group (p less than .05 vs control). The differences in infarct size were not due to differences in myocardial oxygen supply or demand. Neutrophil superoxide anion production was not altered by allopurinol treatment. The results suggest that myocardial xanthine oxidase may generate oxygen radicals that play a role in myocardial injury due to ischemia and reperfusion.
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Citations
Cites
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399
The “no-reflow” phenomenon after temporary coronary occlusion in the dog
Kloner, R. A., Ganote, C. E., & Jennings, R. B. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107898 · Cited by 1,842
Xanthine oxidase as a source of free radical damage in myocardial ischemia
CHAMBERS, D., PARKS, D., PATTERSON, G., ROY, R., MCCORD, J., YOSHIDA, S., PARMLEY, L., & DOWNEY, J. (1985) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(85)80017-1 · Cited by 672
Cited by
Pacher, P., Nivorozhkin, A., & Szabó, C. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.6 · Cited by 1,218
Oxygen-derived free radicals and myocardial reperfusion injury: An overview
Bolli, R. (1991) · Cardiovascular Drugs and Therapy · doi:10.1007/bf00054747 · Cited by 295
Free radicals and myocardial injury: pharmacologic implications.
Werns, S. W., Shea, M. J., & Lucchesi, B. R. (1986) · Circulation · doi:10.1161/01.cir.74.1.1 · Cited by 295
Self-citationYamamoto, T., Moriwaki, Y., Fujimura, Y., Takahashi, S., Tsutsumi, Z., Tsutsui, T., Higashino, K., & Hada, T. (2000) · Pharmacology · doi:10.1159/000028344 · Cited by 24
Metadata
- Authors
- Werns, S. W., Shea, M. J., Mitsos, S. E., Dysko, R. C., Fantone, J. C., Schork, M. A., Abrams, G. D., Pitt, B., & Lucchesi, B. R.
- Venue
- Circulation
- Published
- 1986-03
- Volume
- 73
- Issue
- 3
- Pages
- 518-524
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1994008059
- Cited by
- 190
- References
- 3
- FWCI
- 25.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Werns, S. W., Shea, M. J., Mitsos, S. E., Dysko, R. C., Fantone, J. C., Schork, M. A., Abrams, G. D., Pitt, B., & Lucchesi, B. R. (1986). Reduction of the size of infarction by allopurinol in the ischemic-reperfused canine heart. Circulation. https://doi.org/10.1161/01.cir.73.3.518
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