The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Roles of P2-purinoceptors in the cardiovascular system.
Open accessAbstract
Characterization of P2-purinoceptor subtypes has facilitated understanding of the many diverse effects produced by purine nucleotides. P2X-Purinoceptors are located on vascular smooth muscle where they mediate vasoconstriction resulting from ATP released as a cotransmitter with noradrenaline from sympathetic nerves. P2Y-Purinoceptors are usually located on the vascular endothelium where they have a role as mediators of vascular relaxation by locally produced ATP. In some vessels, P2Y-purinoceptors are also located on the smooth muscle, perhaps in association with purinergic or sensory nerves, where they can elicit direct relaxation to neuronally released ATP. The net effect of ATP and its analogues on isolated vessels or on vascular beds will be the results of actions mediated by P2X- and P2Y-purinoceptor subtypes, although changes in vascular tone and in integrity of nerves and endothelial cells may alter the balance of the response. Such changes have been observed in diseased states (e.g., atherosclerosis) and may have important implications for the involvement of P2-purinoceptors in, for example, vasospasm. The development of selective and potent antagonists to P2X- and P2Y-purinoceptors has so far remained elusive, and their therapeutic potential can only be guessed.
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Cites
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Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D. S., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,769
Role of endothelium in responses of vascular smooth muscle.
Furchgott, R. F. (1983) · Circulation Research · doi:10.1161/01.res.53.5.557 · Cited by 1,949
Extracellular ATP: effects, sources and fate
Gordon, J. L. (1986) · Biochemical Journal · doi:10.1042/bj2330309 · Cited by 1,658
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Is there a basis for distinguishing two types of P2-purinoceptor?
Burnstock, G., & Kennedy, C. (1985) · General Pharmacology: The Vascular System · doi:10.1016/0306-3623(85)90001-1 · Cited by 1,365
Self-citationMartin, W., Villani, G. M., Jothianandan, D., & Furchgott, R. F. (1985) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20898-9 · Cited by 1,257
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Cited by
Tateishi-Yuyama, E., Matsubara, H., Murohara, T., Ikeda, U., Shintani, S., Masaki, H., Amano, K., Kishimoto, Y., Yoshimoto, K., Akashi, H., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09670-8 · Cited by 1,734
Investigators, T. B. (1997) · Circulation · doi:10.1161/01.cir.96.6.1761 · Cited by 619
(2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00533-7 · Cited by 443
Purinergic Signaling and Vascular Cell Proliferation and Death
Burnstock, G. (2002) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/hq0302.105360 · Cited by 414
Self-citationP2 receptors in cardiovascular regulation and disease
Erlinge, D., & Burnstock, G. (2008) · Purinergic Signalling · doi:10.1007/s11302-007-9078-7 · Cited by 344
Self-citation
Metadata
- Authors
- Ralevic, V, & Burnstock, G.
- Venue
- Circulation
- Published
- 1991-07
- Volume
- 84
- Issue
- 1
- Pages
- 1-14
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1588537362
- Cited by
- 472
- References
- 68
- FWCI
- 12.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
