Cited by 174Cardiac electrophysiology and arrhythmiasHeart Rate Variability and Autonomic ControlCardiac pacing and defibrillation studies

Relation between ventricular repolarization duration and cardiac cycle length during 24-hour Holter recordings. Findings in normal patients and patients with long QT syndrome.

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Merri, M, Moss, A J, Benhorin, J, Locati, E H, Alberti, M, Badilini, F·1992·Circulation

Abstract

BACKGROUND: The interval from the R wave to the maximum amplitude of the T wave (RTm) contains the heart rate dependency of ventricular repolarization. METHODS AND RESULTS: A computer algorithm was developed to quantify the RTm and preceding RR intervals for each of more than 50,000 beats on 24-hour ambulatory electrocardiographic (Holter) recordings to evaluate the dynamic relation between repolarization duration and cycle length. The relation of RTm to the preceding RR interval (RTm/RR slope) was determined by the best-fit linear regression equation between these two parameters. Eleven normal subjects and 16 patients with long QT syndrome (LQTS) were investigated. Six of the normal subjects had Holter recordings obtained before and after beta-blocker therapy. beta-Blockers were associated with a significant (p = 0.005) reduction in the RTm/RR slope from 0.13 +/- 0.02 to 0.10 +/- 0.02. The mean value of the RTm/RR slope was significantly (p = 0.003) larger in the LQTS patients (0.21 +/- 0.08) than in normal subjects (0.14 +/- 0.03). CONCLUSIONS: These findings indicate that 1) quantification of the dynamic relation between ventricular repolarization and RR cycle length can be obtained on a large number of Holter-recorded heart beats; 2) beta-blockers reduce the RTm/RR slope in normal patients; and 3) LQTS patients have an exaggerated delay in repolarization at long RR cycle lengths.

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  1. [1]1. Bazett HC: An analysis of the time-relations of electrocardio- grams. Heart 1920;7:353-362
  2. [8]8. Attwell D, Lee JA: A cellular basis for the primary long QT syndrome. Lancet 1988;1:1136-1139
  3. [10]10. Kadish AH, Weisman HF, Veltri EP, Epstein AE, Slepian MJ, Levine JH: Paradoxical effects of exercise on the QT interval in patients with polymorphic ventricular tachycardia receiving type la antiarrhythmic agents. Circulation 1990;81:14-19

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Authors
Merri, M., Moss, A. J., Benhorin, J., Locati, E. H., Alberti, M., & Badilini, F.
Affiliations
University of Rochester (US)
Venue
Circulation
Published
1992-05
Volume
85
Issue
5
Pages
1816-1821
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2158611746
Cited by
174
References
9
Citations by year
2025: 1 · 2024: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 2 · 2012: 3
FWCI
4.03
Type
journal article
Language
en
Open access
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (HL 33843, R01HL033843)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords
long QT syndrome, ventricular repolarization, T wave, RR interval, beta-blockers, Holter monitoring, computational algorithms
MeSH terms
Adult, Diagnosis, Computer-Assisted, Electrophysiology, Female, Heart, Heart Ventricles, Humans, Long QT Syndrome, Male, Reference Values, Regression Analysis, Time Factors, Electrocardiography, Ambulatory

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