The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Molecular biology of the natriuretic peptides and their receptors.
Open accessAbstract
After the description in the past 5 years of BNP and CNP, interest in the natriuretic peptide family has dramatically increased. Molecular characterization of the receptors for this hormone family has identified a heterogeneity in the receptor subtypes not previously alluded to by pharmacological or biochemical studies. Much has been published on the physiology of ANP, but the major roles for BNP and CNP remain to be elucidated. Some experiments indicate that ANP and BNP may act synergistically, especially during cardiac stress; however, the high level of structural diversity of BNP among species and the ability of porcine BNP, but not human BNP, to activate human NPR-B suggest that an as yet unidentified receptor may exist that specifically recognizes BNP. Localization studies have implied that CNP is the most prominent neuropeptide in the natriuretic peptide family, and the restriction of its receptor, NPR-B, to the nervous system suggests that CNP and NPR-B may act in the brain to coordinate the central aspects of body fluid homeostasis. Of the three known NPRs, two, NPR-A and NPR-B, are capable of synthesizing their own second messenger, cGMP. The domain within these receptors that has high homology to protein kinases has been demonstrated to be essential for regulating this activity. No kinase activity has been measured in these proteins, but it is possible that this region is important for ATP regulation of guanylyl cyclase activity. This possibility raises interesting parallels with receptor-mediated cAMP signaling within cells. Seven transmembrane receptors, once activated by ligand, associate with G proteins to affect the activity of adenylyl cyclase.(ABSTRACT TRUNCATED AT 250 WORDS)
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Signal transduction by receptors with tyrosine kinase activity
Ullrich, A., & Schlessinger, J. (1990) · Cell · doi:10.1016/0092-8674(90)90801-k · Cited by 5,435
The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains
Hanks, S. K., Quinn, A. M., & Hunter, T. (1988) · Science · doi:10.1126/science.3291115 · Cited by 5,039
de Bold, A. J., Borenstein, H. B., Veress, A. T., & Sonnenberg, H. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90370-2 · Cited by 3,148
A new natriuretic peptide in porcine brain
Sudoh, T., Kangawa, K., Minamino, N., & Matsuo, H. (1988) · Nature · doi:10.1038/332078a0 · Cited by 1,816
Mukoyama, M., Nakao, K., Hosoda, K., Suga, S., Saito, Y., Ogawa, Y., Shirakami, G., Jougasaki, M., Obata, K., & Yasue, H. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115146 · Cited by 1,354
Purification and complete amino acid sequence of α-human atrial natriuretic polypeptide (α-hANP)
Kangawa, K., & Matsuo, H. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91077-5 · Cited by 1,149
Sudoh, T., Minamino, N., Kangawa, K., & Matsuo, H. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)92401-k · Cited by 1,101
A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor
Chinkers, M., Garbers, D. L., Chang, M.-S., Lowe, D. G., Chin, H., Goeddel, D. V., & Schulz, S. (1989) · Nature · doi:10.1038/338078a0 · Cited by 992
Self-citationPhysiological Role of Silent Receptors of Atrial Natriuretic Factor
Maack, T., Suzuki, M., Almeida, F. A., Nussenzveig, D., Scarborough, R. M., McEnroe, G. A., & Lewicki, J. A. (1987) · Science · doi:10.1126/science.2823385 · Cited by 932
Diverse biological actions of atrial natriuretic peptide
Brenner, B. M., Ballermann, B. J., Gunning, M. E., & Zeidel, M. L. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.3.665 · Cited by 906
Cited by
Therapeutic strategies targeting the endothelial glycocalyx: acute deficits, but great potential
Becker, B. F., Chappell, D., Bruegger, D., Annecke, T., & Jacob, M. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq137 · Cited by 438
Holtwick, R., van Eickels, M., Skryabin, B. V., Baba, H. A., Bubikat, A., Begrow, F., Schneider, M. D., Garbers, D. L., & Kuhn, M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17061 · Cited by 340
Ruskoaho, H., Leskinen, H., Magga, J., Taskinen, P., Mäntymaa, P., Vuolteenaho, O., & Leppäluoto, J. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050179 · Cited by 324
Kapoun, A. M., Liang, F., O’Young, G., Damm, D. L., Quon, D., White, R. T., Munson, K., Lam, A., Schreiner, G. F., & Protter, A. A. (2004) · Circulation Research · doi:10.1161/01.res.0000117070.86556.9f · Cited by 302
Natriuretic peptides in cardiometabolic regulation and disease
Zois, N. E., Bartels, E. D., Hunter, I., Kousholt, B. S., Olsen, L. H., & Goetze, J. P. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.64 · Cited by 182
Metadata
- Authors
- Koller, K. J., & Goeddel, D. V.
- Venue
- Circulation
- Published
- 1992-10
- Volume
- 86
- Issue
- 4
- Pages
- 1081-1088
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1970407496
- Cited by
- 416
- References
- 60
- FWCI
- 12.91
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Molecular biology of the natriuretic peptides and their receptors. https://app.cochat.ai/papers/10.1161/01.cir.86.4.1081
- The paper
- Koller, K. J., & Goeddel, D. V. (1992). Molecular biology of the natriuretic peptides and their receptors. Circulation. https://doi.org/10.1161/01.cir.86.4.1081
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
