Evidence for an association between dehydroepiandrosterone sulfate and nonfatal, premature myocardial infarction in males
Open accessAbstract
BACKGROUND: Several studies indicate that endogenous hormones play a role in the etiology of coronary artery disease, either as independent risk factors or indirectly, via an effect on lipids, lipoproteins, or other heart disease risk factors. METHODS AND RESULTS: The relation between endogenous hormone levels and premature (< 56-year-old patients) myocardial infarction was assessed in a retrospective study involving 49 male survivors of premature myocardial infarction and 49 age-matched, volunteer male controls. Serum samples were obtained for each subject the morning after a > or = 12-hour fast and frozen at -70 degrees C for subsequent hormonal analysis. Among the male patients, the average duration between the most recent myocardial infarction and blood sampling was 3.4 years (range, 0.7 to 19.2 years). Individuals reporting the use of any medications with the potential to alter lipid, lipoprotein, or hormone levels were excluded from these analyses. Dehydroepiandrosterone sulfate levels were significantly lower in the patients than in the control subjects. This association remained statistically significant even after accounting for the effects of total cholesterol, triglycerides, the ratio of total to high-density lipoprotein (HDL) cholesterol, HDL, apolipoprotein A-I, apolipoprotein A-II, apolipoprotein B, and body mass index. There were no significant differences in the levels of estradiol, testosterone, or free testosterone or the ratio of estradiol to testosterone between patients and control subjects. CONCLUSIONS: Our conclusions are limited by the retrospective nature of this study. However, these data indicate that serum dehydroepiandrosterone sulfate levels are inversely related to premature myocardial infarction in males and that this association is independent of the effects of several known risk factors for premature myocardial infarction.
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Low levels of DHEA and DHEA-S are associated with elevated risk of cardiovascular disease.
“Low levels of both DHEA and DHEA-S are associated with elevated risk of cardiovascular disease.98-100”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [98]
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A prospective study of dehydroepiandrosterone sulfate, mortality and cardiovascular disease.
Barrett-Connor, E., Khaw, K.-T., & Yen, S. S. C. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612113152405 · Cited by 681 · see citing works
Endogenous sex hormones and cardiovascular disease in men. A prospective population-based study.
Barrett-Connor, E. L., & Khaw, K. (1988) · Circulation · doi:10.1161/01.cir.78.3.539 · Cited by 367 · see citing works
Atherosclerosis in Transgenic Mice Overexpressing Apolipoprotein A-II
Warden, C. H., Hedrick, C. C., Qiao, J.-H., Castellani, L. W., & Lusis, A. J. (1993) · Science · doi:10.1126/science.8332912 · Cited by 359 · see citing works
Rosenfield, R. L. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-32-6-717 · Cited by 186 · see citing works
Herrington, D. M., Gordon, G. B., Achuff, S. C., Trejo, J. F., Weisman, H. F., Kwiterovich, P. O., & Pearson, T. A. (1990) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(10)80334-1 · Cited by 147 · see citing works
Phillips, G. B. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.4.1729 · Cited by 142 · see citing works
Association of hyperestrogenemia and coronary heart disease in men in the Framingham cohort
Phillips, G. B., Castelli, W. P., Abbott, R. D., & McNamara, P. M. (1983) · The American Journal of Medicine · doi:10.1016/0002-9343(83)91078-1 · Cited by 137 · see citing works
Hormonal studies and physical maturation in adolescent gynecomastia
Biro, F. M., Lucky, A. W., Huster, G. A., & Morrison, J. A. (1990) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)82843-4 · Cited by 133 · see citing works
Usefulness of sex steroid hormone levels in predicting coronary artery disease in men
Cauley, J. A., Gutai, J. P., Kuller, L. H., & Dai, W. S. (1987) · The American Journal of Cardiology · doi:10.1016/0002-9149(87)91021-6 · Cited by 129 · see citing works
Fruchart, J. C., & Ailhaud, G. P. (1992) · Clinical Chemistry · doi:10.1093/clinchem/38.6.793 · Cited by 121 · see citing works
LaCroix, A. Z., Yano, K., & REED, D. M. (1992) · Circulation · doi:10.1161/01.cir.86.5.1529 · Cited by 118 · see citing works
Mendoza, S. G., Zerpa, A., Carrasco, H., et al. (1983) · PubMed · Cited by 115 · see citing works
EVIDENCE FOR HYPERŒSTROGENÆMIA AS A RISK FACTOR FOR MYOCARDIAL INFARCTION IN MEN
Phillips, G. (1976) · The Lancet · doi:10.1016/s0140-6736(76)92968-8 · Cited by 111 · see citing works
Contoreggi, C. S., Blackman, M. R., Andres, R., Muller, D. C., Lakatta, E. G., Fleg, J. L., & Harman, S. M. (1990) · Journal of Andrology · doi:10.1002/j.1939-4640.1990.tb00178.x · Cited by 98 · see citing works
SOWINSKASRZEDNICKA, J., Zgliczyński, S., Ciświcka-Sznajderman, M., Srzednicki, M., Soszynski, P. A., Biernacka, M., Woroszylska, M., RUZO, W., & SADOWSKI, Z. (1989) · Atherosclerosis · doi:10.1016/0021-9150(89)90124-x · Cited by 74 · see citing works
Phillips, G. B., Yano, K., & Stemmermann, G. N. (1988) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(88)90018-2 · Cited by 74 · see citing works
Abnormal hormone levels in men with coronary artery disease.
Zumoff, B., Troxler, R. G., O'Connor, J., Rosenfeld, R. S., Kream, J., Levin, J., Hickman, J. R., Sloan, A., Walker, W. J., Cook, R. L., et al. (1982) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.2.1.58 · Cited by 73 · see citing works
Serum estrogen levels in men with acute myocardial infarction
Klaiber, E. L., Broverman, D. M., Haffajee, C. I., Hochman, J. S., Sacks, G. M., & Dalen, J. E. (1982) · The American Journal of Medicine · doi:10.1016/0002-9343(82)90779-3 · Cited by 70 · see citing works
Stein, E. A., DiPersio, L. P., PESCE, A. J., et al. (1986) · Clinical Chemistry · doi:10.1093/clinchem/32.6.967 · Cited by 69 · see citing works
Relationship Between Sex Hormones, Myocardial Infarction, and Occlusive Coronary Disease
Luria, M. H. (1982) · Archives of Internal Medicine · doi:10.1001/archinte.1982.00340140044011 · Cited by 68 · see citing works
RAISED PLASMA ŒSTRADIOL AND ŒSTRONE LEVELS IN YOUNG SURVIVORS OF MYOCARDIAL INFARCTION
Entrican, J. H., Beach, C., Carroll, D., Kenmure, A. C., Klopper, A. I., Mackie, M., & Douglas, A. S. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92215-8 · Cited by 65 · see citing works
Labropoulos, B., Velonakis, E., Oekonomakos, P., et al. (2008) · Cardiology · doi:10.1159/000173490 · Cited by 52 · see citing works
Sewdarsen, M., Vythilingum, S., Jalal, I., et al. (1990) · Atherosclerosis · doi:10.1016/0021-9150(90)90156-d · Cited by 43 · see citing works
Sex hormone levels in young Indian patients with myocardial infarction.
Sewdarsen, M., Jialal, I., Vythilingum, S., & Desai, R. K. (1986) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.6.4.418 · Cited by 36 · see citing works
Plasma testosterone and serum lipids in male survivors of myocardial infarction
Poggi, U. L., ARGUELLES, A. E., Rosner, J. M., Laborde, N. P., Cassini, J. H., & Volmer, M. C. (1976) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(76)90206-5 · Cited by 35 · see citing works
Apolipoproteins, Dyslipoproteinaemia and Premature Coronary Heart Disease
Hamsten, A. (1988) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1988.tb15890.x · Cited by 25 · see citing works
Inhibitory action of dehydroepiandrosterone (DHEA) on fibroblast growth
Saenger, P. H., & New, M. I. (1977) · Cellular and Molecular Life Sciences · doi:10.1007/bf01951309 · Cited by 24 · see citing works
Relationship between sex hormones, myocardial infarction, and occlusive coronary disease
Luria, M. H. (1982) · Archives of Internal Medicine · doi:10.1001/archinte.142.1.42 · Cited by 19 · see citing works
Estradiol Levels in Myocardial Infarction
Winter, J. H. (1982) · Archives of Internal Medicine · doi:10.1001/archinte.1982.00340210179036 · Cited by 7 · see citing works
Serum estrogen levels in men with acute myocardial infarction
(1982) · The American Journal of Medicine · doi:10.1016/0002-9343(82)90790-2 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Stein EA, DiPersio L, Pesce AJ, Kashyap M, Kao JT, Srivastava L, McNerney C. Enzyme linked immunoabsorbant assay of apolipo- protein All in plasma, with the use of monoclonal antibody. Clin Chem. 1986;32:967-971.
- Sonka J, Gregorova I. Effet regulateur de la dehydroepiandros- terone sur le metabolisme. J Physiol (Lond). 1964;317:711.
- Hamstein A. Apolipoproteins, dyslipoproteinemia and premature coronary artery disease. Acta Med Scand. 1988;223:389-403.
Cited by
Sorted by citations
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Ärnlöv, J., Pencina, M. J., Amin, S., Nam, B.-H., Benjamin, E. J., Murabito, J. M., Wang, T. J., Knapp, P. E., D'Agostino, R. B., Bhasin, S., et al. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-3-200608010-00005 · Cited by 217 · see citing works
Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications
Pataky, M. W., Young, W. F., & Nair, K. S. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.07.033 · Cited by 207 · see citing works
Feldman, H. A., Johannes, C. B., Araujo, A. B., Mohr, B. A., Longcope, C., & McKinlay, J. B. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.1.79 · Cited by 141 · see citing works
Dehydroepiandrosterone and coronary atherosclerosis
HERRINGTON, D. M. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17387.x-i1 · Cited by 75 · see citing works
- Authors
- Mitchell, L. E., Sprecher, D. L., Borecki, I. B., Rice, T., Laskarzewski, P. M., & Rao, D. C.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Circulation
- Published
- 1994-01
- Volume
- 89
- Issue
- 1
- Pages
- 89-93
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2046612946
- Cited by
- 116
- References
- 30
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hd018281-08)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 18281)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- dehydroepiandrosterone sulfate, premature myocardial infarction, coronary artery disease, endogenous hormones, male survivors, serum hormone levels, apolipoproteins, estradiol to testosterone ratio, testosterone, estradiol
- MeSH terms
- Age Factors, Dehydroepiandrosterone, Estradiol, Humans, Lipoproteins, Male, Middle Aged, Myocardial Infarction, Ohio, Retrospective Studies, Risk Factors, Testosterone, Multivariate Analysis, Case-Control Studies, Dehydroepiandrosterone Sulfate
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