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Cited by 141Hormonal and reproductive studiesAdrenal Hormones and DisordersMenopause: Health Impacts and Treatments

Low dehydroepiandrosterone and ischemic heart disease in middle-aged men: prospective results from the Massachusetts Male Aging Study

Feldman, Henry A., Johannes, Catherine B., Araujo, Andre B., Mohr, Beth A., Longcope, Christopher, McKinlay, John B.·2001·American Journal of Epidemiology
DOI 10.1093/aje/153.1.79
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Abstract

The adrenal steroid dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) have been characterized as "protective" against ischemic heart disease (IHD), especially in men, on the basis of sparse epidemiologic evidence. The authors used data from the Massachusetts Male Aging Study, a random sample prospective study of 1,709 men aged 40-70 years at baseline, to test whether serum levels of DHEA or DHEAS could predict incident IHD over a 9-year interval. At baseline (1987-1989) and follow-up (1995-1997), an interviewer-phlebotomist visited each subject in his home to obtain comprehensive health information, body measurements, and blood samples for hormone and lipid analysis. Incident IHD between baseline and follow-up was ascertained from hospital records and death registries, supplemented by self-report and evidence of medication. In the analysis sample of 1,167 men, those with serum DHEAS in the lowest quartile at baseline (<1.6 microg/ml) were significantly more likely to incur IHD by follow-up (adjusted odds ratio = 1.60, 95 percent confidence interval: 1.07, 2.39; p = 0.02), independently of a comprehensive set of known risk factors including age, obesity, diabetes, hypertension, smoking, serum lipids, alcohol intake, and physical activity. Low serum DHEA was similarly predictive. These results confirm prior evidence that low DHEA and DHEAS can predict IHD in men.

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  • In 40-70 year old men in the lowest quartile for plasma DHEA or DHEA-S, there is a significantly greater risk for ischemic heart disease.

    “Feldman et al. reported that in 40-70 year old men in the lowest quartile for plasma DHEA or DHEA-S there was a significantly greater risk for ischemic heart disease.101”

    From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [101]

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Authors
Feldman, H. A., Johannes, C. B., Araujo, A. B., Mohr, B. A., Longcope, C., & McKinlay, J. B.
Affiliations
New England Research Institutes (US)
ORCID
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2001-01-01
Volume
153
Issue
1
Pages
79-89
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
DOI
10.1093/aje/153.1.79
OpenAlex
W2051423109
Cited by
141
References
76
Citations by year
2025: 3 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 11 · 2013: 4 · 2012: 5
FWCI
7.12
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r03hl050482-02, 7p01ag004673-05)
  • National Institute on Aging (AG 04673)
  • National Heart, Lung, and Blood Institute (HL-50482)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK044995, DK44995)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
dehydroepiandrosterone, dehydroepiandrosterone sulfate, ischemic heart disease, middle-aged men, serum steroid levels, cardiovascular risk prediction, Massachusetts Male Aging Study
MeSH terms
Adult, Aged, Aging, Dehydroepiandrosterone, Humans, Male, Massachusetts, Middle Aged, Predictive Value of Tests, Prospective Studies, Risk Factors, Cohort Studies, Incidence, Myocardial Ischemia, Dehydroepiandrosterone Sulfate

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