Associations of the HDL2 and HDL3 cholesterol subfractions with the development of ischemic heart disease in British men. The Caerphilly and Speedwell Collaborative Heart Disease Studies.

Sweetnam, P M; Bolton, C H; Yarnell, J W; Bainton, D; Baker, I A; Elwood, P C; Miller, N E

doi:10.1161/01.cir.90.2.769

Cited by 98Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismParaoxonase enzyme and polymorphisms

Associations of the HDL2 and HDL3 cholesterol subfractions with the development of ischemic heart disease in British men. The Caerphilly and Speedwell Collaborative Heart Disease Studies.

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Sweetnam, P M, Bolton, C H, Yarnell, J W, Bainton, D, Baker, I A, Elwood, P C, Miller, N E·1994·Circulation

DOI 10.1161/01.cir.90.2.769

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Abstract

BACKGROUND: The relative importance of HDL2 and HDL3 cholesterol as risk factors for ischemic heart disease (IHD) is still uncertain. Their associations with the incidence of IHD in the Caerphilly and Speedwell prospective studies are described. METHODS AND RESULTS: The two studies have a common core protocol and are based on a total of 4860 middle-aged men from the general population. The first follow-up was at a nearly constant interval of 5.1 years in Caerphilly and 3.2 years in Speedwell: 251 major IHD events had occurred. Lipid levels were measured on fasting samples. Different laboratories were used by the two studies. Each laboratory used ultracentrifugation to separate HDL2 and HDL3. Both subfractions were inversely associated with risk of IHD. Standardized relative odds of developing major IHD were 0.95 (95% confidence interval [CI], 0.80 to 1.14) for HDL2 cholesterol and 0.83 (95% CI, 0.68 to 1.00) for HDL3 cholesterol in Caerphilly and 0.76 (95% CI, 0.57 to 1.01) for HDL2 and 0.64 (95% CI, 0.49 to 0.83) for HDL3 in Speedwell. The association with incident IHD appeared to be stronger for HDL3 in both areas. No linear combination of the two subfractions was a better predictor of IHD than total HDL cholesterol alone. CONCLUSIONS: In British men, both HDL2 and HDL3 cholesterol are inversely associated with the incidence of IHD. However, the prediction of the risk of IHD from total HDL cholesterol alone could not be improved upon by measurement of the two HDL subfractions. The relative value of the two HDL subfractions as predictors of risk is still unresolved. The uncertainty may be due, at least in part, to problems associated with their measurement.

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Epidemiological studies have not provided conclusive evidence that measurement of HDL size contributes to risk prediction.
“Epidemiological studies have not provided conclusive evidence that measurement of HDL size contributes to risk prediction (36, 50 -55).”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [51]

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Authors: Sweetnam, P. M., Bolton, C. H., Yarnell, J. W., Bainton, D., Baker, I. A., Elwood, P. C., & Miller, N. E.
Affiliations: University Hospital Llandough (GB)
ORCID: Bolton, C H
Baker, I A
Elwood, P C
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1994-08
Volume: 90
Issue: 2
Pages: 769-774
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.90.2.769
OpenAlex: W2057375091
Cited by: 98
References: 16
Citations by year: 2025: 1 · 2023: 1 · 2021: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 5
FWCI: 4.35
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: HDL2, HDL3 cholesterol, HDL subfractions, ischemic heart disease, coronary heart disease incidence, cardiovascular risk factors, middle-aged men
MeSH terms: Follow-Up Studies, United Kingdom, Humans, Lipoproteins, HDL, Cholesterol, HDL, Male, Middle Aged, Prospective Studies, Risk Factors, Time Factors, Cohort Studies, Incidence, Myocardial Ischemia, Lipoproteins, HDL2, Lipoproteins, HDL3

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Associations of the HDL2 and HDL3 cholesterol subfractions with the development of ischemic heart disease in British men. The Caerphilly and Speedwell Collaborative Heart Disease Studies.

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