CoChat
Sign Up
Cited by 183Heart Rate Variability and Autonomic ControlCardiovascular and exercise physiologyBlood Pressure and Hypertension Studies

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Effects of Aging on the Responsiveness of the Human Cardiac Sympathetic Nerves to Stressors

Esler, Murray D., Thompson, Jane M., Kaye, David M., Turner, Andrea G., Jennings, Garry L., Cox, Helen S., Lambert, Gavin W., Seals, Douglas R.·1995·Circulation
DOI 10.1161/01.cir.91.2.351
Open this paper in CoChat — free account

Abstract

Background Aging increases human sympathetic nervous activity at rest. Because of the probable importance of neural stress responses in the heart as triggers for clinical end points of coronary artery disease, it is pertinent to investigate whether sympathetic nervous responses to stresses are increased by aging. Methods and Results We applied kinetic methods for measuring the fluxes to plasma of neurochemicals relevant to sympathetic neurotransmission in younger (aged 20 to 30 years) and older (aged 60 to 75 years) healthy men during mental stress (difficult mental arithmetic), isometric exercise (sustained handgrip), and dynamic exercise (supine cycling). The increase in total norepinephrine spillover to plasma with mental stress was unaffected by age. In contrast, the increase in cardiac norepinephrine spillover was two to three times higher in the older subjects (P<.05). The probable mechanism of this higher cardiac norepinephrine spillover was reduced neuronal reuptake of the transmitter, because age had no influence on the overflow of the norepinephrine precursor, dihydroxyphenylalanine, or intraneuronal metabolite, dihydroxyphenylglycol (levels of these two substances reflect rates of cardiac norepinephrine synthesis and intraneuronal metabolism), and the transcardiac extraction of plasma radiolabeled norepinephrine was lower in the older subjects (P<.05). An almost identical pattern of neurochemical response was seen with isometric exercise. During cycling, total norepinephrine spillover was 16% lower in the older men, but cardiac norepinephrine spillover was 53% higher. Conclusions Reduced norepinephrine reuptake increases the overflow of the neurotransmitter to plasma from the aging heart during stimulation of the cardiac sympathetic outflow. Failure of transmitter inactivation at postjunctional receptors with aging would amplify the neural signal, and in the presence of myocardial disease could trigger adverse stress-induced cardiovascular events, particularly when accompanied by an age-dependent reduction in vagal tone. Reduction of postsynaptic adrenergic responsiveness with aging, however, might protect against this, as indicated by our finding that in no case was the heart rate increase during stress greater in older men, despite their having larger increases in cardiac norepinephrine spillover.

Overview

Integrity signals

Registry

Crossref · 10.1161/01.cir.91.2.351

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 8

  1. 10.1161/circ.80.4.2571430 · DOI
  2. 10.1161/res.53.1.6861300 · DOI
  3. 10.1161/circ.85.5.1572033 · DOI
  4. 10.1161/circ.78.1.3383409 · DOI
  5. Cox HS Kaye DM Thompson J Itsiopoulos C Turner AG Esler MD. Testing for possible causes of obesity hypertension: regional sympathetic responses to a large meal in healthy subjects. Proceedings of the 15th Scientific Meeting of the International Society of Hypertension. Melbourne Australia; 1994:S227.
  6. 10.1161/circ.88.3.8394783 · DOI
  7. 10.1161/res.33.1.9 · DOI
  8. 10.1161/circ.90.3.8087932 · DOI

Cited by

Sorted by citations

See all 183

Related

See all

Metadata

Authors
Esler, M. D., Thompson, J. M., Kaye, D. M., Turner, A. G., Jennings, G. L., Cox, H. S., Lambert, G. W., & Seals, D. R.
Affiliations
University of Colorado Boulder (US)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1995-01-15
Volume
91
Issue
2
Pages
351-358
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.91.2.351
OpenAlex
W2011392057
Cited by
183
References
51
Citations by year
2026: 3 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 6 · 2018: 8 · 2017: 6 · 2016: 7 · 2015: 8 · 2014: 2 · 2013: 6 · 2012: 3
FWCI
5.81
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (R01-AG-06537-07, R01AG006537)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
aging, cardiac sympathetic nervous system, norepinephrine spillover, norepinephrine uptake, psychological stress, isometric exercise, dynamic exercise, DOPA, DOPAC, vagal tone, coronary artery disease, heart rate response
MeSH terms
Adult, Aged, Aging, Blood Pressure, Dihydroxyphenylalanine, Heart, Heart Rate, Humans, Male, Methoxyhydroxyphenylglycol, Middle Aged, Myocardium, Norepinephrine, Rest, Stress, Psychological, Sympathetic Nervous System, Exercise, Neurotransmitter Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review