CoChat
Sign Up
Cited by 220Blood Pressure and Hypertension StudiesHeart Rate Variability and Autonomic ControlCardiovascular and exercise physiology

Age-related changes in muscle sympathetic nerve activity in essential hypertension

Yamada, Y, Miyajima, E, Tochikubo, O, Matsukawa, T, Ishii, M·1989·Hypertension
DOI 10.1161/01.hyp.13.6.870
Open this paper in CoChat — free account

Abstract

To investigate the pathophysiological role of the sympathetic nervous system in essential hypertension, this study recorded the muscle sympathetic nerve activity (MSNA) of the tibial nerve and examined the age-related changes in patients with essential hypertension and in normotensive persons. There were 43 normotensive subjects (16-69 years old) and 63 patients with essential hypertension (18-67 years old) in the study. The MSNA at rest, recorded by microneurography, was evaluated by burst rate (bursts/min), burst incidence (bursts/100 heart beats), and spike frequency (spikes/min). The MSNA recording showed a high reproducibility with a correlation coefficient of 0.86 (p less than 0.01) in repeated studies. The MSNA was significantly greater in the hypertensive patients than in the normotensive subjects, irrespective of activity units (p less than 0.01), and this finding was consistent in the young (30 years old or less), middle-aged (31-50 years old), and old groups (51 years old or more). Furthermore, MSNA showed a significant positive correlation with age both in the normotensive subjects (r = 0.43, p less than 0.01 for burst rate; r = 0.49, p less than 0.01 for burst incidence; and r = 0.50, p less than 0.01 for spike frequency) and in the hypertensive patients (r = 0.40, p less than 0.01 for burst rate; r = 0.44, p less than 0.01 for burst incidence; and r = 0.40, p less than 0.01 for spike frequency).(ABSTRACT TRUNCATED AT 250 WORDS)

Integrity signals

Registry

Crossref · 10.1161/01.hyp.13.6.870

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In benign essential hypertensives, MSNA at rest is mildly elevated compared with normotensives.

    “Also in benign essential hypertensives, MSNA at rest has been shown to be mildly elevated as compared with normotensives in our previous study (6).”

    From Elevated sympathetic nerve activity in patients with accelerated essential hypertension. (1993) · cites this paper as [6]

  • The results obtained from MSNA recordings in this study were similar to those previously published in age-comparable hypertensive subjects.

    “The results obtained from MSNA recordings in this study were similar to those previously published in age-comparable hypertensive subjects (15,16,25,26,28).”

    From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [25]

  • Patients with hypertension have a greater frequency of MSNA bursts than properly matched normotensive subjects.

    “Despite the difficulty of establishing that every unit within a burst has a vasoconstrictor role, there is a wealth of evidence to suggest that patients with hypertension have a greater frequency of MSNA bursts than properly matched normotensive subjects (15,25–27).”

    From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [25]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Yamada, Y., Miyajima, E., Tochikubo, O., Matsukawa, T., & Ishii, M.
Affiliations
Yokohama City University (JP)
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1989-06
Volume
13
Issue
6_pt_2
Pages
870-877
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/01.hyp.13.6.870
OpenAlex
W2171483164
Cited by
220
References
38
Citations by year
2026: 1 · 2025: 6 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 1 · 2020: 8 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 7 · 2015: 6 · 2014: 10 · 2013: 5 · 2012: 3
FWCI
3.37
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
muscle sympathetic nerve activity, essential hypertension, age-related changes, sympathetic nervous system, tibial nerve, burst frequency, spike frequency, microneurography, reproducibility
MeSH terms
Adolescent, Adult, Aged, Aging, Electrophysiology, Female, Humans, Hypertension, Male, Middle Aged, Muscles, Norepinephrine, Osmolar Concentration, Reference Values, Sympathetic Nervous System, Tibial Nerve

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review