The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Medical Therapy Can Improve the Biological Properties of the Chronically Failing Heart: A New Era in the Treatment of Heart Failure
Abstract
Abstract Myocardial failure has been considered to be an irreversible and progressive process characterized by ventricular enlargement, chamber geometric alterations, and diminished pump performance. However, more recent evidence has suggested that certain types of medical therapy may lead to retardation and even reversal of the cardiomyopathic process. In the failing heart, long-term neurohormonal/autocrine-paracrine activation results in abnormalities in myocyte growth, energy production and utilization, calcium flux, and receptor regulation that produce a progressively dysfunctional, mechanically inefficient heart. Interventions such as ACE inhibition and β-blockade result in a reduction in the harmful long-term consequences of neurohormonal/autocrine-paracrine effects and retard the progression of left ventricular dysfunction or ventricular remodeling. Furthermore, in subjects with idiopathic dilated or ischemic cardiomyopathy, antiadrenergic therapy with β-blocking agents appears to be able to partially reverse systolic dysfunction and ventricular remodeling. Although the precise mechanisms underlying this latter effect have not yet been elucidated, the general mechanism appears to be via improvement in the biological function of the cardiac myocyte. Such an improvement in the intrinsic defect(s) responsible for myocardial failure will likely translate into important clinical benefits.
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Cites
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Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure
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Cited by
Bristow, M. R., Gilbert, E. M., Abraham, W. T., Adams, K. F., Fowler, M. B., Hershberger, R. E., Kubo, S. H., Narahara, K. A., Ingersoll, H., Krueger, S., et al. (1996) · Circulation · doi:10.1161/01.cir.94.11.2807 · Cited by 1,303
Self-citationChronic Heart Failure in the United States: A Manifestation of Coronary Artery Disease
Gheorghiade, M., & Bonow, R. O. (1998) · Circulation · doi:10.1161/01.cir.97.3.282 · Cited by 787
Mechanisms and Models in Heart Failure: A Combinatorial Approach
Mann, D. L. (1999) · Circulation · doi:10.1161/01.cir.100.9.999 · Cited by 773
Animal Models of Heart Failure: A Scientific Statement From the American Heart Association
Houser, S. R., Margulies, K. B., Murphy, A. M., Spinale, F. G., Francis, G. S., Prabhu, S. D., Rockman, H. A., Kass, D. A., Molkentin, J. D., Sussman, M. A., et al. (2012) · Circulation Research · doi:10.1161/res.0b013e3182582523 · Cited by 435
Return to the fetal gene program: A suggested metabolic link to gene expression in the heart
Taegtmeyer, H., Sen, S., & Vela, D. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05100.x · Cited by 411
Metadata
- Authors
- Eichhorn, E. J., & Bristow, M. R.
- Venue
- Circulation
- Published
- 1996-11
- Volume
- 94
- Issue
- 9
- Pages
- 2285-2296
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2021315555
- Cited by
- 468
- References
- 7
- FWCI
- 24.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Medical Therapy Can Improve the Biological Properties of the Chronically Failing Heart: A New Era in the Treatment of Heart Failure. https://app.cochat.ai/papers/10.1161/01.cir.94.9.2285
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- Eichhorn, E. J., & Bristow, M. R. (1996). Medical Therapy Can Improve the Biological Properties of the Chronically Failing Heart: A New Era in the Treatment of Heart Failure. Circulation. https://doi.org/10.1161/01.cir.94.9.2285
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
