The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Return to the fetal gene program: A suggested metabolic link to gene expression in the heart
Open accessAbstract
A hallmark of cardiac metabolism before birth is the predominance of carbohydrate use for energy provision. After birth, energy substrate metabolism rapidly switches to the oxidation of fatty acids. This switch accompanies the expression of “adult” isoforms of metabolic enzymes and other proteins. However, in a variety of pathophysiologic conditions, including hypoxia, ischemia, hypertrophy, atrophy, diabetes, and hypothyroidism, the postnatal heart returns to the “fetal” gene program. These adaptive mechanisms are also a feature of the failing heart muscle, where at a certain point this fetal‐like reprogramming no longer suffices to support cardiac structure and function. We advance the hypothesis that in the postnatal heart, metabolic remodeling triggers the process through glycosylation of transcription factors, potentially protecting the stressed heart from irreversible functional impairment and programmed cell death. In other words, we propose a metabolic link to gene expression in the heart.
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Cites
Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis
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Role of Akt/protein kinase B in metabolism
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Metabolic Gene Expression in Fetal and Failing Human Heart
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Self-citationReturn to the fetal gene program protects the stressed heart: a strong hypothesis
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Self-citationUnloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy
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Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure
Sun, H., Olson, K. C., Gao, C., Prosdocimo, D. A., Zhou, M., Wang, Z., Jeyaraj, D., Youn, J.-Y., Ren, S., Liu, Y., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.020226 · Cited by 538
Treatment with thyroid hormone
Biondi, B., & Wartofsky, L. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1083 · Cited by 259
Drawnel, F. M., Boccardo, S., Prummer, M., Delobel, F., Graff, A., Weber, M., Gérard, R., Badi, L., Kam-Thong, T., Bu, L., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.055 · Cited by 247
Fuel availability and fate in cardiac metabolism: a tale of two substrates
Pascual, F., & Coleman, R. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.03.014 · Cited by 125
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Metadata
- Authors
- Taegtmeyer, H., Sen, S., & Vela, D.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2010-02
- Volume
- 1188
- Issue
- 1
- Pages
- 191-198
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1938218641
- Cited by
- 411
- References
- 46
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Taegtmeyer, H., Sen, S., & Vela, D. (2010). Return to the fetal gene program: A suggested metabolic link to gene expression in the heart. Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.2009.05100.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
