The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Coronary Endothelial Dysfunction in Humans Is Associated With Myocardial Perfusion Defects
Abstract
Background Coronary endothelial dysfunction may occur in patients with minimally obstructive coronary artery disease and angina, and potentially may cause myocardial ischemia. Methods and Results Coronary endothelium-dependent vasodilation was examined in patients with angina and <50% coronary artery diameter (CAD) stenosis by selectively infusing acetylcholine (10 −6 mol/L to 10 −4 mol/L) into the left anterior descending coronary artery (LAD). Percent change in CAD (%ΔCAD) was measured by quantitative coronary angiography, and percent change in coronary blood flow (%ΔCBF) was calculated using intracoronary flow Doppler. Coronary endothelium-independent vasodilation was examined using intracoronary adenosine and nitroglycerin. 99m Tc sestamibi was injected intravenously just prior to the infusion of the highest dose of acetylcholine. Patients were divided blindly into three groups: Perfusion defects in non-LAD territory (group 1, n=6), no perfusion defects (group 2, n=7), and perfusion defects in the LAD territory (group 3, n=7). All patients had intact endothelium-independent vasodilation. In group 1, perfusion defects outside the LAD territory reflected an increase in %ΔCAD and %ΔCBF by 24±5% and 241±46% in the LAD. In group 2, %ΔCAD decreased by 26±5%, but %ΔCBF increased by 54±17%. In group 3, perfusion defects were within the LAD territory, reflecting a decrease in %ΔCAD and %ΔCBF by 35±5% and 51±14%, respectively. Conclusions This study demonstrates that coronary endothelial dysfunction in humans may be temporally associated with myocardial perfusion defects and supports a role for the coronary epicardial and microcirculation endothelium in regulating myocardial perfusion. Myocardial ischemia may occur in humans with impaired endothelium-dependent coronary flow reserve of the coronary epicardial and microcirculation.
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Self-citationAtherosclerosis influences the vasomotor response of epicardial coronary arteries to exercise.
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Endothelial Function: Cardiac Events
Lerman, A., & Zeiher, A. M. (2005) · Circulation · doi:10.1161/01.cir.0000153339.27064.14 · Cited by 1,096
Self-citationPrognostic Significance of Endothelial Dysfunction in Hypertensive Patients
Perticone, F., Ceravolo, R., Pujia, A., Ventura, G., Iacopino, S., Scozzafava, A., Ferraro, A., Chello, M., Mastroroberto, P., Verdecchia, P., et al. (2001) · Circulation · doi:10.1161/01.cir.104.2.191 · Cited by 1,059
Schiffrin, E. L., Park, J. B., Intengan, H. D., & Touyz, R. M. (2000) · Circulation · doi:10.1161/01.cir.101.14.1653 · Cited by 616
von Mering, G. O., Arant, C. B., Wessel, T. R., McGorray, S. P., Bairey Merz, C. N., Sharaf, B. L., Smith, K. M., Olson, M. B., Johnson, B. D., Sopko, G., et al. (2004) · Circulation · doi:10.1161/01.cir.0000115525.92645.16 · Cited by 369
Detection of Coronary Artery Disease in Asymptomatic Patients With Type 2 Diabetes Mellitus
Scognamiglio, R., Negut, C., Ramondo, A., Tiengo, A., & Avogaro, A. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.10.008 · Cited by 249
Metadata
- Authors
- Hasdai, D., Gibbons, R. J., Holmes, D. R., Higano, S. T., & Lerman, A.
- Venue
- Circulation
- Published
- 1997-11-18
- Volume
- 96
- Issue
- 10
- Pages
- 3390-3395
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1988516817
- Cited by
- 398
- References
- 27
- FWCI
- 19.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hasdai, D., Gibbons, R. J., Holmes, D. R., Higano, S. T., & Lerman, A. (1997). Coronary Endothelial Dysfunction in Humans Is Associated With Myocardial Perfusion Defects. Circulation. https://doi.org/10.1161/01.cir.96.10.3390
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