The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Androgen Receptors Mediate Hypertrophy in Cardiac Myocytes
Open accessAbstract
Background —The role of androgens in producing cardiac hypertrophy by direct action on cardiac myocytes is uncertain. Accordingly, we tested the hypothesis that cardiac myocytes in adult men and women express an androgen receptor gene and that myocytes respond to androgens by a hypertrophic response. Methods and Results —We used reverse transcription–polymerase chain reaction methods to demonstrate androgen receptor transcripts in multiple tissues and [ 3 H]phenylalanine incorporation and atrial natriuretic peptide secretion as markers of hypertrophy in cultured rat myocytes. Messenger RNA encoding androgen receptors was detected in myocytes of male and female adult rats, neonatal rat myocytes, rat heart, dog heart, and infant and adult human heart. Both testosterone and dihydrotestosterone produced a robust receptor-specific hypertrophic response in myocytes, determined by indices of protein synthesis and atrial natriuretic peptide secretion. Conclusions —Androgen receptors are present in cardiac myocytes from multiple species, including normal men and women, in a context that permits androgens to modulate the cardiac phenotype and produce hypertrophy by direct, receptor-specific mechanisms. There are clinical implications for therapeutic or illicit use of androgens in humans.
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Cited by
Smith, J. C., Bennett, S., Evans, L. M., Kynaston, H. G., Parmar, M., Mason, M. D., Cockcroft, J. R., Scanlon, M. F., & Davies, J. S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7851 · Cited by 458
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Influence of sex hormones and phytoestrogens on heart disease in men and women
Bhupathy, P., Haines, C. D., & Leinwand, L. A. (2010) · Women s Health · doi:10.2217/whe.09.80 · Cited by 125
Metadata
- Authors
- Marsh, J. D., Lehmann, M. H., Ritchie, R. H., Gwathmey, J. K., Green, G. E., & Schiebinger, R. J.
- Venue
- Circulation
- Published
- 1998-07-21
- Volume
- 98
- Issue
- 3
- Pages
- 256-261
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2151007116
- Cited by
- 432
- References
- 41
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Marsh, J. D., Lehmann, M. H., Ritchie, R. H., Gwathmey, J. K., Green, G. E., & Schiebinger, R. J. (1998). Androgen Receptors Mediate Hypertrophy in Cardiac Myocytes. Circulation. https://doi.org/10.1161/01.cir.98.3.256
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
