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Cited by 145Inflammatory mediators and NSAID effectsBlood Pressure and Hypertension StudiesEicosanoids and Hypertension Pharmacology

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Nonnarcotic Analgesic Use and the Risk of Hypertension in US Women

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Dedier, Julien, Stampfer, Meir J., Hankinson, Susan E., Willett, Walter C., Speizer, Frank E., Curhan, Gary C.·2002·Hypertension
DOI 10.1161/01.hyp.0000035856.77718.da
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Abstract

Acetaminophen, aspirin, and other nonsteroidal anti-inflammatory drugs (NSAIDs) are widely consumed. Each is theoretically capable of elevating blood pressure by altering prostaglandin homeostasis; however, there is little prospective information on the relation between these agents and physician-diagnosed hypertension. We examined the association between the use of aspirin, acetaminophen, or NSAIDs and incident hypertension in a prospective cohort study of 51 630 women 44 to 69 years of age in 1990 who had no history of hypertension or chronic renal insufficiency. Analgesic use was assessed in 1990 by a mailed questionnaire, and the women were followed for 8 years. The primary outcome was physician-diagnosed hypertension reported on a follow-up biennial questionnaire. During 381 078 person-years of follow-up, 10 579 incident cases of hypertension were identified. Compared with nonusers, women who used aspirin or acetaminophen at least 1 day per month or NSAIDs 5 or more days per month were at a significantly higher risk for development of hypertension. After adjusting for potential confounders, the odds ratios for women in the highest frequency of use category (≥22 days per month) compared with no use were as follows: aspirin, 1.21 (95% CI, 1.13 to 1.30); acetaminophen, 1.20 (1.08 to 1.33); and NSAIDs, 1.35 (1.25 to 1.46). For each analgesic type, there was a significant trend toward an increased risk of incident hypertension with increasing frequency of use ( P <0.001). Given the observed odds ratios, biologic plausibility, and the sizeable population at risk, health professionals should consider potential hypertensive effects of aspirin, acetaminophen, and NSAIDs when counseling their patients about the use of nonnarcotic analgesics.

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Crossref · 10.1161/01.hyp.0000035856.77718.da

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Research works printed but not linked: 3

  1. Kaufman DW, Kelly JP, Anderson TE, Rosenberg L, Mitchell AA. A comprehensive population-based survey of medication use in the United States: the adult population. Pharmacoepidemiol Drug Saf. 2000; 9: S60.
  2. Colditz GA. The nurses’ health study: a cohort of US women followed since 1976. J Am Med Womens Assoc. 1995; 50: 40–44.
  3. Cinotti GA, Pugliese F. Prostaglandins in blood pressure regulation. Kidney Int Suppl. 1988; 25: S57–S60.

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Metadata

Authors
Dedier, J., Stampfer, M. J., Hankinson, S. E., Willett, W. C., Speizer, F. E., & Curhan, G. C.
Affiliations
Brigham and Women's Hospital (US)
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-11
Volume
40
Issue
5
Pages
604-608
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/01.hyp.0000035856.77718.da
OpenAlex
W2080325388
Cited by
145
References
23
Citations by year
2025: 1 · 2024: 6 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 10 · 2014: 6 · 2013: 8 · 2012: 7
FWCI
4.44
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders
  • National Institutes of Health
  • National Cancer Institute (CA-87969, P01CA087969)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK052866, DK52866)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords
non-opioid analgesics, aspirin, paracetamol, nonsteroidal anti-inflammatory drugs, blood pressure, prostaglandins, women, drug safety, incident hypertension risk
MeSH terms
Acetaminophen, Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Blood Pressure, Female, Follow-Up Studies, Humans, Hypertension, Middle Aged, Nurses, Prospective Studies, Surveys and Questionnaires, Risk, Risk Factors, United States, Cohort Studies, Incidence, Multivariate Analysis, Odds Ratio, Analgesics, Non-Narcotic

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