DNA hypomethylation of inflammation-associated genes in adipose tissue of female mice after multigenerational high fat diet feeding
Abstract
Objective Maternal obesity significantly increases the susceptibility of offspring to develop obesity and chronic diseases in adulthood. The offspring of obese mothers are shown to prefer high fat diet (HFD) due to their altered neural circuitry, creating a 'feed-forward cycle' across generations. We hypothesized that the 'feed-forward cycle' caused by multigenerational HFD feeding would have exacerbated effects in adipose tissue of the offspring. Methods Three generations (F0, F1 and F2) of HFD (60% Kcal fat)-fed and corresponding normal chow (NC)-fed C57BL/6 mice were generated. Body weight (BW) and food intake were monitored weekly. Parametrial adipose tissue (pAT) weight and endocrine parameters were measured in 9-month-old female offspring. Gene expression microarray, quantitative RT-PCR and bisulfite sequencing were performed using pAT. Results BW and pAT weight increased in female mice across generations under continuous HFD stress, with the most severe phenotype found in the F2 generation. Genes involved in inflammatory response showed increased expression across generations in the pAT, accompanied by increased macrophage infiltration. The promoters of Toll-like receptor 1 (Tlr1), Tlr2 and linker for activation of T cells (Lat) were hypomethylated in the HF groups compared with the NC group, with additional hypomethylation on some specific CpG sites in the F2 generation. Conclusions A feed-forward cycle exists in female mice after continuous HFD stress as demonstrated by increased adiposity and progressive inflammation in adipose tissue across generations. DNA hypomethylation over generations lead to epigenetically altered expression of Tlr1, Tlr2 and Lat, which may contribute to the inflammation in adipose tissue. Our study provides a potential mechanism for enhanced inflammation in adipose tissue under multigenerational HFD-fed stress.
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In mice, female progeny of obese dams exposed to high-fat diet displayed obesity and high levels of WAT inflammation in association with hypomethylation at certain inflammatory genes for three generations.
“For example, in mice, female progeny of obese dams exposed to high-fat diet displayed obesity and high levels of WAT inflammation in association with hypomethylation at certain inflammatory genes for three generations [153].”
From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [153]
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- Authors
- Ding, Y., Li, J., Liu, S., Zhang, L., Xiao, H., Li, J., Chen, H., Petersen, R. B., Huang, K., & Zheng, L.
- Affiliations
- Wuhan University (CN)
- Huazhong University of Science and Technology (CN)
- Case Western Reserve University (US)
- Wuhan Institute of Bioengineering (CN)
- Corresponding author
- Huang, K
- Zheng, L
- Venue
- International Journal of Obesity
- Published
- 2013-05-27
- Volume
- 38
- Issue
- 2
- Pages
- 198-204
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2074164379
- Cited by
- 76
- References
- 48
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 8 · 2021: 9 · 2020: 6 · 2019: 10 · 2018: 6 · 2017: 12 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 3
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- DNA hypomethylation, maternal obesity, adipose tissue inflammation, TLR1, TLR2, linker for activation of T cells, CpG methylation, epigenetic inheritance, macrophage infiltration, female obesity, adiposity
- MeSH terms
- Adipose Tissue, Animals, Birth Weight, Eating, Female, Immunohistochemistry, Inflammation, Mice, Inbred C57BL, Obesity, Pregnancy, Prenatal Exposure Delayed Effects, Gene Expression Regulation, Developmental, DNA Methylation, Genetic Predisposition to Disease, Maternal Nutritional Physiological Phenomena, Epigenesis, Genetic, Mice, Diet, High-Fat
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