The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Peroxisome Proliferator-Activated Receptors: Vascular and Cardiac Effects in Hypertension
Open accessAbstract
Peroxisome proliferator-activated receptors (PPAR) are nuclear receptors acting as transcription factors on numerous target genes after heterodimerization with the retinoid X receptor. PPAR-α and PPAR-γ may be activated by different agonists, although the endogenous ligands are unknown. Although PPAR-α is mainly involved in fatty acid oxidation and expressed in liver, kidney, and skeletal muscle, and PPAR-γ is mainly involved in fat cell differentiation and insulin sensitivity, both are expressed in smooth muscle cells and myocardium, although PPAR-γ are scarce in the latter. Activators of PPAR-α such as fatty acids and fibrates, and PPAR-γ such as thiazolidinediones have been shown to exert antiproliferative effects, antagonize angiotensin II actions in vivo and in vitro, and exert antioxidant actions inhibiting generation of reactive oxygen species and activation of inflammatory mediators on blood vessels and the heart. These agents lowered blood pressure in several models of hypertension and corrected endothelial dysfunction. They exerted anti-inflammatory and antifibrotic actions on blood vessels and the heart. With the development of dual α/γ-PPAR activators, these newer agents may become interesting therapeutic agents for prevention of vascular and cardiac complications of hypertension as well as for preventative therapy in other forms of cardiovascular disease.
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Cites
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Cited by
AMP-activated protein kinase and its downstream transcriptional pathways
Cantó, C., & Auwerx, J. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0454-z · Cited by 421
Pharmacological approaches to restore mitochondrial function
Andreux, P. A., Houtkooper, R. H., & Auwerx, J. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4023 · Cited by 383
Vascular endothelin in hypertension
Schiffrin, E. L. (2005) · Vascular Pharmacology · doi:10.1016/j.vph.2005.03.004 · Cited by 305
Self-citationIncreased Myocardial Fatty Acid Metabolism in Patients With Type 1 Diabetes Mellitus
Herrero, P., Peterson, L. R., McGill, J. B., Matthew, S., Lesniak, D., Dence, C., & Gropler, R. J. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.09.030 · Cited by 265
Carvacrol, a component of thyme oil, activates PPARα and γ and suppresses COX-2 expression
Hotta, M., Nakata, R., Katsukawa, M., Hori, K., Takahashi, S., & Inoue, H. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m900255-jlr200 · Cited by 260
Metadata
- Authors
- Schiffrin, E. L., Amiri, F., Benkirane, K., Iglarz, M., & Diep, Q. N.
- Venue
- Hypertension
- Published
- 2003-10
- Volume
- 42
- Issue
- 4
- Pages
- 664-668
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2159719851
- Cited by
- 369
- References
- 54
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schiffrin, E. L., Amiri, F., Benkirane, K., Iglarz, M., & Diep, Q. N. (2003). Peroxisome Proliferator-Activated Receptors: Vascular and Cardiac Effects in Hypertension. Hypertension. https://doi.org/10.1161/01.hyp.0000084370.74777.b6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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