The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Obesity-Associated Hypertension: New Insights Into Mechanisms
Abstract
Obesity is strongly associated with hypertension and cardiovascular disease. Several central and peripheral abnormalities that can explain the development or maintenance of high arterial pressure in obesity have been identified. These include activation of the sympathetic nervous system and the renin-angiotensin–aldosterone system. Obesity is also associated with endothelial dysfunction and renal functional abnormalities that may play a role in the development of hypertension. The continuing discovery of mechanisms regulating appetite and metabolism is likely to lead to new therapies for obesity-induced hypertension. Better understanding of leptin signaling in the hypothalamus and the mechanisms of leptin resistance should facilitate therapeutic approaches to reverse the phenomenon of selective leptin resistance. Other hunger and satiety signals such as ghrelin and peptide YY are potentially attractive therapeutic strategies for treatment of obesity and its complications. These recent discoveries should lead to novel strategies for treatment of obesity and hypertension.
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Cites
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Splanchnic lipolysis in human obesity
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Adiponectin acts in the brain to decrease body weight
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Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice
Münzberg, H., Flier, J. S., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2004-0726 · Cited by 737
Mori, H., Hanada, R., Hanada, T., Aki, D., Mashima, R., Nishinakamura, H., Torisu, T., Chien, K. R., Yasukawa, H., & Yoshimura, A. (2004) · Nature Medicine · doi:10.1038/nm1071 · Cited by 651
Sympathetic Neural Activation in Visceral Obesity
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Regional Sympathetic Nervous Activity and Oxygen Consumption in Obese Normotensive Human Subjects
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Cited by
Seravalle, G., & Grassi, G. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.05.013 · Cited by 909
Sympathetic Nervous System Overactivity and Its Role in the Development of Cardiovascular Disease
Malpas, S. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00007.2009 · Cited by 699
Elevated body mass index is associated with executive dysfunction in otherwise healthy adults
Gunstad, J., Paul, R. H., Cohen, R. A., Tate, D. F., Spitznagel, M. B., & Gordon, E. (2007) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2006.05.001 · Cited by 668
Obesity-induced Hypertension: Role of Sympathetic Nervous System, Leptin, and Melanocortins
Hall, J. E., da Silva, A. A., do Carmo, J. M., Dubinion, J., Hamza, S., Munusamy, S., Smith, G., & Stec, D. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.113175 · Cited by 528
Brennan, A. M., & Mantzoros, C. S. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0196 · Cited by 374
Metadata
- Authors
- Rahmouni, K., Correia, M. L. G., Haynes, W. G., & Mark, A. L.
- Venue
- Hypertension
- Published
- 2005-01
- Volume
- 45
- Issue
- 1
- Pages
- 9-14
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2144375073
- Cited by
- 784
- References
- 16
- FWCI
- 20.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rahmouni, K., Correia, M. L. G., Haynes, W. G., & Mark, A. L. (2005). Obesity-Associated Hypertension: New Insights Into Mechanisms. Hypertension. https://doi.org/10.1161/01.hyp.0000151325.83008.b4
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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