The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Relationship Between Aortic Stiffening and Microvascular Disease in Brain and Kidney: Cause and Logic of Therapy
Abstract
A close relationship has been established between microvascular damage in brain and kidney and indices of age and hypertension (pulse pressure, aortic pulse wave velocity, and augmentation index). The mechanism of such association has not been established, nor has rationale for prevention and treatment of microvascular damage. A logical pathophysiological explanation can be offered on the basis of differential input impedance in the brain and kidney compared with other systemic vascular beds. Torrential flow and low resistance to flow in these organs exposes small arterial vessels to the high-pressure fluctuations that exist in the carotid, vertebral, and renal arteries. Such fluctuations, measurable as central pulse pressure, increase 3- to 4-fold with age. Exposure of small vessels to highly pulsatile pressure and flow explains microvascular damage and resulting renal insufficiency and intellectual deterioration, according to the mechanism established by Byrom >50 years ago. The logical approach to prevention and treatment requires reduction of central pulse pressure. Because the aorta and large arteries are not directly affected by drugs, this entails reduction of wave reflection by dilation of conduit arteries elsewhere in the body. This can be accomplished by regular exercise and by drugs such as nitrates, calcium channel blockers, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers. The explanation given here accounts for greater and earlier vascular damage in diabetes mellitus (relative microvascular fragility) and is similar to that given for vascular changes of pulmonary hypertension caused by ventricular septal defects and other congenital vascular shunts.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Several pathways may link aortic stiffness to microvascular brain damage. They include endothelial dysfunction and oxidative stress,209 a mutually reinforcing remodeling of large and small vessels (ie, large-/small-artery cross talk),210 and exposure of small vessels to the high-pressure fluctuations of the cerebral circulation,211”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Laurent, S., Boutouyrie, P., Asmar, R., Gautier, I., Laloux, B., Guize, L., Ducimetiere, P., & Benetos, A. (2001) · Hypertension · doi:10.1161/01.hyp.37.5.1236 · Cited by 3,856
Hemodynamic Patterns of Age-Related Changes in Blood Pressure: The Framingham Heart Study
Franklin, S. S., Gustin, W., Wong, N. D., Larson, M. G., Weber, M. A., Kannel, W. B., & Levy, D. (1997) · Circulation · doi:10.1161/01.cir.96.1.308 · Cited by 2,321
Hypertension : pathophysiology, diagnosis, and management
Laragh, J. H., & Brenner, B. M. (1995) · Raven Press eBooks · Cited by 1,932
Aortic Stiffness Is an Independent Predictor of Primary Coronary Events in Hypertensive Patients
Boutouyrie, P., Tropeano, A., Asmar, R. G., Gautier, I., Bénétos, A., Lacolley, P. J., & Laurent, S. (2002) · Hypertension · doi:10.1161/hy0102.099031 · Cited by 1,745
McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles
Vlachopoulos, C., O'Rourke, M., & Nichols, W. W. (2011) · doi:10.1201/b13568 · Cited by 1,613
Self-citationArterial Calcifications, Arterial Stiffness, and Cardiovascular Risk in End-Stage Renal Disease
Blacher, J., Guérin, A. P., Pannier, B., Marchais, S. J., & London, G. M. (2001) · Hypertension · doi:10.1161/hy1001.096358 · Cited by 1,416
Pauca, A. L., O’Rourke, M. F., & Kon, N. D. (2001) · Hypertension · doi:10.1161/hy1001.096106 · Cited by 1,179
Self-citationArterial stiffness, wave reflections, and the risk of coronary artery disease
Weber, T., Auer, J., O’Rourke, M. F., Kvas, E., Lassnig, E., Berent, R., & Eber, B. (2004) · Circulation · doi:10.1161/01.cir.0000105767.94169.e3 · Cited by 1,081
Self-citationAortic Stiffness Is an Independent Predictor of Fatal Stroke in Essential Hypertension
Laurent, S., Katsahian, S., Fassot, C., Tropeano, A., Gautier, I., Laloux, B., & Boutouyrie, P. (2003) · Stroke · doi:10.1161/01.str.0000065428.03209.64 · Cited by 1,058
Impact of Aortic Stiffness Attenuation on Survival of Patients in End-Stage Renal Failure
Guérin, A. P., Blacher, J., Pannier, B., Marchais, S. J., Safar, M. E., & London, G. M. (2001) · Circulation · doi:10.1161/01.cir.103.7.987 · Cited by 1,038
Self-citation
Research works printed but not linked: 15
- 10.1161/hyp.39.3.735 · DOI
- 10.1161/hyp.39.1.10 · DOI
- 10.1161/hyp.38.4.938 · DOI
- 10.1161/hyp.37.5.1236 · DOI
- 10.1161/atvb.21.12.2046 · DOI
- 10.1161/hyp.38.3.429 · DOI
- SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug therapy in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA. 1991; 365: 3255–3264.
- 10.1161/hyp.38.4.932 · DOI
- 10.1161/res.16.5.401 · DOI
- 10.1161/res.25.6.637 · DOI
- 10.1161/res.27.6.921 · DOI
- 10.1161/res.66.1.2403863 · DOI
- 10.1161/circ.96.1.308 · DOI
- 10.1161/circ.103.7.987 · DOI
- 10.1161/circ.15.2.164 · DOI
Cited by
Sorted by citations
Items 101–200 of 999
Vrselja, Z., Brkić, H., Mrđenović, S., Radić, R., & Ćurić, G. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.7 · Cited by 134
Vascular disease and dementias: Paradigm shifts to drive research in new directions
Kling, M. A., Trojanowski, J. Q., Wolk, D. A., Lee, V. M. ‐., & Arnold, S. E. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.02.007 · Cited by 137
“Aging-associated biomechanical changes Aging is associated with increased stiffness of arteries as a result of fragmentation and depletion of elastin and increased deposition of collagen in the vessel wall [93,94].”
BackgroundCharacteristics of healthy vascular ageing in pooled population-based cohort studies
Nilsson, P. M., Laurent, S., Cunha, P., Olsen, M. H., Rietzschel, E. R., Franco, O. H., Ryliškytė, L., Strazhesko, I. D., Vlachopoulos, C. V., Chen, C., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001824 · Cited by 132
“The cushioning function depends on the viscoelastic properties of arterial walls and on the arterial geometry [1,2].”
Early vascular aging and the role of central blood pressure
Kotsis, V., Stabouli, S., Karafillis, I., & Nilsson, P. M. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834a4d9f · Cited by 130
Is Hypertension Associated With an Accelerated Aging of the Brain?
Tzourio, C., Laurent, S., & Debette, S. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.00147 · Cited by 136
Pase, M. P., Herbert, A., Grima, N., Pipingas, A., & OʼRourke, M. F. (2011) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2011.02645.x · Cited by 139
Self-citationTarumi, T., Gonzales, M. M., Fallow, B. A., Nualnim, N., Pyron, M. I., Tanaka, H., & Haley, A. P. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e328364decc · Cited by 134
“aorta and common carotid artery) effectively buffer pulsatile hemodynamic energy generated from the heart and create continuous blood flow in the periphery [3,4].”
BackgroundInfluentialthe Italian Diabetes Society and the Italian Society of Nephrology, Pugliese, G., Penno, G., Natali, A., Barutta, F., Paolo, S. D., Reboldi, G., Gesualdo, L., & Nicola, L. D. (2019) · Journal of Nephrology · doi:10.1007/s40620-019-00650-x · Cited by 135
Aortic Distensibility and Retinal Arteriolar Narrowing: The Multi-Ethnic Study of Atherosclerosis
Cheung, N., Sharrett, A. R., Klein, R., Criqui, M. H., Islam, F. M. A., Macura, K. J., Cotch, M. F., Klein, B. E. K., & Wong, T. Y. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.091926 · Cited by 124
Less Atherosclerosis and Lower Blood Pressure for a Meaningful Life Perspective With More Brain
Staessen, J. A., Richart, T., & Birkenhäger, W. H. (2007) · Hypertension · doi:10.1161/01.hyp.0000258151.00728.d8 · Cited by 128
Extracellular matrix dynamics in vascular remodeling
Ma, Z., Mao, C., Jia, Y., Fu, Y., & Kong, W. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00147.2020 · Cited by 129
Aortic Pulse Wave Velocity Is Associated With Measures of Subclinical Target Organ Damage
Coutinho, T. A., Turner, S. T., & Kullo, I. J. (2011) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2011.04.011 · Cited by 122
Mediation Analysis of Aortic Stiffness and Renal Microvascular Function
Woodard, T., Sigurdsson, S. O., Gotal, J. D., Torjesen, A. A., Inker, L. A., Aspelund, T., Eiríksdóttir, G., Gudnason, V. G., Harris, T. B., Launer, L. J., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014050450 · Cited by 122
Effects of Arterial Stiffness on Brain Integrity in Young Adults From the Framingham Heart Study
Maillard, P., Mitchell, G. F., Himali, J. J., Beiser, A., Tsao, C. W., Pase, M. P., Satizábal, C. L., Vasan, R. S., Seshadri, S. S., & DeCarli, C. S. (2016) · Stroke · doi:10.1161/strokeaha.116.012949 · Cited by 122
“brain injury by exposing the small vessels of the cerebral vasculature to high pressure fluctuations and flow pulsatility.(21)”
BackgroundPant, S., Fabrèges, B., Gerbeau, J.-F., & Vignon-Clementel, I. E. (2014) · International Journal for Numerical Methods in Biomedical Engineering · doi:10.1002/cnm.2692 · Cited by 119
“The increased proximal to distal resistance ratio is also compatible with [55, 57], although individual branch changes may”
ResultMolshatzki, N., Orion, D., Tsabari, R., Schwammenthal, Y., Merzeliak, O., Toashi, M., & Tanné, D. (2010) · Cerebrovascular Diseases · doi:10.1159/000322155 · Cited by 116
“Indeed, kidney and brain are end organs that are vulnerable to hypertensive damage [”
BackgroundArterial Pressure, Heart Rate, and Cerebral Hemodynamics Across the Adult Life Span
Xing, C., Tarumi, T., Meijers, R. L., Turner, M., Repshas, J., Xiong, L., Ding, K., Vongpatanasin, W., Yuan, L.-J., & Zhang, R. (2017) · Hypertension · doi:10.1161/hypertensionaha.116.08986 · Cited by 116
Arterial stiffness and stroke: de-stiffening strategy, a therapeutic target for stroke
Chen, Y., Shen, F., Liu, J., & Yang, G. (2017) · Stroke and Vascular Neurology · doi:10.1136/svn-2016-000045 · Cited by 116
“arterial stiffness damages the cerebral microvasculature and causes impaired cognition function.(33) 51 54 Furthermore, the measured higher aortic stiffness may”
BackgroundHypertension and Its Role in Cognitive Function: Current Evidence and Challenges for the Future
Hughes, T. M., & Sink, K. M. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv180 · Cited by 117
An Integrated View on Vascular Dysfunction in Alzheimer’s Disease
Klohs, J. (2019) · Neurodegenerative Diseases · doi:10.1159/000505625 · Cited by 111
Lu, Y., Zollner-Kiechl, S., Wang, J., Xu, Q., Kiechl, S. J., Pechlaner, R., Aguilar, D. A., Al-Hashmi, K., Alvim, R. D. O., Al-Zakwani, I. S., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104619 · Cited by 114
Assessment and significance of arterial stiffness in patients with chronic kidney disease
Guérin, A. P., Pannier, B., Métivier, F., Marchais, S. J., & London, G. M. (2008) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e32830dcd5c · Cited by 112
Pase, M. P., Grima, N., & Sarris, J. J. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511002819 · Cited by 113
“Putative relationships also exist between arterial stiffness and brain as well as kidney end-organ damage((2)).”
BackgroundBrachial-Ankle Pulse Wave Velocity Predicts Increase in Blood Pressure and Onset of Hypertension
Takase, H., Dohi, Y., Toriyama, T., Okado, T., Tanaka, S., Sonoda, H., Sato, K., & Kimura, G. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.19 · Cited by 109
Bronas, U. G., Puzantian, H. V., & Hannan, M. F. (2017) · BioMed Research International · doi:10.1155/2017/2726369 · Cited by 122
“High-pressure flow from large arteries, in addition to low resistance to flow in small vessels in vital organs, causes subsequent damage to vessels exposed to high pulsatility [108].”
Backgroundde Montgolfier, O., Pinçon, A., Pouliot, P., Gillis, M., Bishop, J. E., Sled, J. G., Villeneuve, L. R., Ferland, G., Levy, B. I., Lesage, F., et al. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.12048 · Cited by 119
Tarumi, T., Shah, F., Tanaka, H., & Haley, A. P. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.101 · Cited by 108
Pulse Wave Velocity and Cognitive Decline in Elders
Hazzouri, A. Z. A., Newman, A. B., Simonsick, E. M., Sink, K. M., Tyrrell, K. S., Watson, N. L., Satterfield, S., Harris, T. B., Yaffe, K. S., & Study, F. T. H. A. (2013) · Stroke · doi:10.1161/strokeaha.112.673533 · Cited by 109
Determinants of Vascular Age: An Epidemiological Perspective
Kucharska‐Newton, A., Stoner, L. R., & Meyer, M. L. (2018) · Clinical Chemistry · doi:10.1373/clinchem.2018.287623 · Cited by 109
Llena, I. R., Jiménez-Baladó, J., Castañé, X., Girona, A., López‐Rueda, A., Mundet, X., Jarca, C. I., Álvarez‐Sabín, J., Montaner, J., & Delgado, P. (2018) · Stroke · doi:10.1161/strokeaha.118.020163 · Cited by 107
Microcirculation and Macrocirculation in Hypertension: A Dangerous Cross-Link?
Laurent, S., Rosei, C. A., Bruno, R. M., & Rizzoni, D. (2022) · Hypertension · doi:10.1161/hypertensionaha.121.17962 · Cited by 111
Stone, J., Johnstone, D. M., Mitrofanis, J., & O’Rourke, M. F. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141884 · Cited by 113
“retains pulsations transmitted through the capillary network” [132].”
InfluentialSelf-citationAortic Stiffness Determines Diastolic Blood Flow Reversal in the Descending Thoracic Aorta
Hashimoto, J., & Ito, S. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01318 · Cited by 106
LaDisa, J. F., Dholakia, R., Figueroa, C. A., Vignon-Clementel, I. E., Chan, F. P., Samyn, M. M., Cava, J. R., Taylor, C. A., & Feinstein, J. A. (2011) · Congenital Heart Disease · doi:10.1111/j.1747-0803.2011.00553.x · Cited by 105
Boutouyrie, P., Fliser, D., Goldsmith, D. J. A., Covic, A. C., Więcek, A., Ortíz, A., Martinez-Castelao, A., Lindholm, B., Massy, Z. A., Süleymanlar, G., et al. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft309 · Cited by 105
Time-Varying Myocardial Stress and Systolic Pressure-Stress Relationship
Chirinos, J. A., Segers, P., Gupta, A. K., Swillens, A., Rietzschel, E. R., Buyzere, M. D., Kirkpatrick, J. N., Gillebert, T. C., Wang, Y., Keane, M. G., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.829366 · Cited by 105
Disentangling the multiple links between renal dysfunction and cerebrovascular disease
Kelly, D., & Rothwell, P. M. (2019) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2019-320526 · Cited by 105
Mechanisms of Stroke in Patients with Chronic Kidney Disease
Ghoshal, S., & Freedman, B. I. (2019) · American Journal of Nephrology · doi:10.1159/000502446 · Cited by 106
Arterial function in youth: window into cardiovascular risk
Fernhall, B., & Agiovlasitis, S. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00001.2008 · Cited by 105
“organ damage such as stroke or renal failure ( 70 ).”
BackgroundInfluentialQuinn, U., Tomlinson, L. A., & Cockcroft, J. R. (2012) · JRSM Cardiovascular Disease · doi:10.1258/cvd.2012.012024 · Cited by 104
Arterial Stiffness and Cognitive Decline in Well-Functioning Older Adults
Watson, N. L., Sutton-Tyrrell, K., Rosano, C., Boudreau, R. M., Hardy, S. E., Simonsick, E. M., Najjar, S. S., Launer, L. J., Yaffe, K. S., Atkinson, H. H., et al. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr119 · Cited by 103
“First, the loss of cushioning capacity of the stiffened aorta allows damaging central pulse pressures to be transmitted to the fragile small vessels of target organs (7,8).”
BackgroundArterial Stiffness in CKD: A Review
Townsend, R. R. (2018) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2018.04.005 · Cited by 103
Hashimoto, J., Nichols, W. W., O'Rourke, M. F., & Imai, Y. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2007.49 · Cited by 111
Self-citationTomiyama, H., Tanaka, H., Hashimoto, H., Matsumoto, C., Odaira, M., Yamada, J., Yoshida, M., Shiina, K., Nagata, M., & Yamashina, A. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.05.033 · Cited by 105
Mechanical and structural changes in human thoracic aortas with age
Jadidi, M., Habibnezhad, M., Anttila, E. D., Maleckis, K., Desyatova, A. S., MacTaggart, J., & Kamenskiy, A. V. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.12.024 · Cited by 102
Risk factors for vascular dementia: Hypotension as a key point
Moretti, R. (2008) · Vascular Health and Risk Management · doi:10.2147/vhrm.s2434 · Cited by 102
“Portions of less severe incomplete white matter infarcts may not be demonstrable on brain imaging, causing clinical-pathological correlation diffi culties (Brun 1994; Englund 2000, 2004).”
Impaired kidney function and cerebral microbleeds in patients with acute ischemic stroke
Cho, A. H., Lee, S. B., Han, S., Shon, Y., Yang, D. W., & Kim, B. S. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c1defa · Cited by 101
Bolduc, V., Thorin‐Trescases, N., & Thorin, É. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00624.2012 · Cited by 105
“Because cerebral blood flow (CBF) is tightly coupled to neuronal metabolic demand (1, 25, 56, 142), the development of chronic brain hypoperfusion together with the increase in inter-capillary distances [for review (38)] promotes progressive hypometabolism (168), chronic blood-brain barrier (BBB) inflammation , and le…”
BackgroundInfluentialArterial Stiffness Assessed by Cardio-Ankle Vascular Index
Namba, T., Masaki, N., Takase, B., & Adachi, T. K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153664 · Cited by 103
“Especially, brain and kidney arteries are subjected to the pulsatile stress [90].”
BackgroundReview of ‘the Potential Role of Arterial Stiffness in the Pathogenesis of Alzheimer’s Disease’
Hughes, T. M., Craft, S., & López, O. L. (2015) · Neurodegenerative Disease Management · doi:10.2217/nmt.14.53 · Cited by 105
Sakuragi, S., & Abhayaratna, W. P. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.04.027 · Cited by 99
Gumz, M. L., Shimbo, D., Abdalla, M., Balijepalli, R. C., Benedict, C., Chen, Y., Earnest, D. J., Gamble, K. L., Garrison, S., Gong, M. C., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19372 · Cited by 105
Relationship of Ankle Blood Pressures to Cardiovascular Events in Older Adults
Sutton‐Tyrrell, K., Venkitachalam, L., Kanaya, A. M., Boudreau, R. M., Harris, T. B., Thompson, T., Mackey, R. H., Visser, M., Vaidean, G. D., & Newman, A. B. (2008) · Stroke · doi:10.1161/strokeaha.107.487439 · Cited by 99
Effect of S-equol and Soy Isoflavones on Heart and Brain
Sekikawa, A. M., Ihara, M., López, O. L., Kakuta, C., Lopresti, B. J., Higashiyama, A., Aizenstein, H. J., Chang, Y., Mathis, C. A., Miyamoto, Y., et al. (2018) · Current Cardiology Reviews · doi:10.2174/1573403x15666181205104717 · Cited by 102
“, white matter hyperintensities, ventricular enlargement, small cerebral infarct) [212, 213], which in turn are risk factors for dementia [214].”
BackgroundHägg-Holmberg, S., Thorn, L. M., Jukka Putaala, A., Liebkind, R., Harjutsalo, V., Forsblom, C. M., Gordin, D., Tatlisumak, T., Groop, P., & on behalf of the FinnDiane Study Group (2013) · Diabetes Care · doi:10.2337/dc13-0669 · Cited by 97
“Our finding of SDR and DN as independent risk factors for stroke is consistent with earlier findings that the vasculature of the retina (27) and the kidney (28) show partly similar pathophysiological features and mechanisms as the vasculature in the brain.”
ResultAntihypertensive treatment can prevent stroke and cognitive decline
Sörös, P., Whitehead, S. N., Spence, J. D., & Hachinski, V. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.255 · Cited by 99
Peralta, C. A., Jacobs, D. R., Katz, R., Ix, J. H., Madero, M., Duprez, D. A., Sarnak, M. J., Criqui, M. H., Kramer, H., Palmas, W., et al. (2011) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2011.08.015 · Cited by 96
The Vicious Cycle of Arterial Stiffness and Arterial Media Calcification
den Bergh, G. V., Opdebeeck, B., D’Haese, P. C., & Verhulst, A. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.08.006 · Cited by 96
Relationship between silent brain infarction and chronic kidney disease
Kobayashi, M., Hirawa, N., Yatsu, K., Kobayashi, Y., Yamamoto, Y., Saka, S., Andoh, D., Toya, Y., Yasuda, G., & Umemura, S. (2008) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn419 · Cited by 97
Association of Arterial Rigidity with Incident Kidney Disease and Kidney Function Decline
Madero, M., Peralta, C. A., Katz, R., Canada, R. B., Fried, L. P., Najjar, S. S., Shlipak, M. G., Simonsick, E. M., Lakatta, E. G., Patel, K. V., et al. (2012) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.07900812 · Cited by 94
“Damage to small arteries induced by increased pulsatile stress may lead to tearing of the endothelial and smooth muscle cells with disruption of the vessel, predisposing to thrombosis and microinfarction (7).”
BackgroundPulsatile Hemodynamics and Microcirculation
Muiesan, M. L., Salvetti, M., Rizzoni, D., Paini, A., Agabiti-Rosei, C., Aggiusti, C., Bertacchini, F., Stassaldi, D., Gavazzi, A., Porteri, E., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.00006 · Cited by 93
Renal dysfunction in cardiovascular diseases and its consequences
Deferrari, G., Cipriani, A., & Porta, E. L. (2020) · Journal of Nephrology · doi:10.1007/s40620-020-00842-w · Cited by 97
Large Artery Stiffening With Weight Gain in Humans
Orr, J. S., Gentile, C. L., Davy, B. M., & Davy, K. P. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.112946 · Cited by 94
Exercise Improves Vascular Function, but does this Translate to the Brain?
Barnes, J. N., & Corkery, A. T. (2018) · Brain Plasticity · doi:10.3233/bpl-180075 · Cited by 105
Álvarez‐Bueno, C., Cunha, P., Martínez‐Vizcaíno, V., Pozuelo‐Carrascosa, D. P., Visier‐Alfonso, M. E., Jiménez‐López, E., & Cavero‐Redondo, I. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.014621 · Cited by 98
Fan, F., Qi, L., Jia, J., Xu, X., Liu, Y., Yang, Y., Qin, X., Li, J., Li, H., Zhang, Y., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.07019 · Cited by 84
“Because of relatively torrential flow and low resistance in an organ such as the kidney, small arterial vessels tend to be exposed to the high-pressure fluctuations more exactly reflected by central pressures.(27) It stands to reason that higher cSBP was a better indicator of microvascular damage and resulting increas…”
ResultArterial Stiffness, Pulse Pressure, and the Kidney
Safar, M. E., Plante, G. E., & Mimran, A. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu206 · Cited by 92
Self-citationArterial Stiffness in Chronic Kidney Disease and End-Stage Renal Disease
London, G. M. (2018) · Blood Purification · doi:10.1159/000485146 · Cited by 92
Disturbance of macro- and microcirculation: relations with pulse pressure and cardiac organ damage
Safar, M. E., & Lacolley, P. J. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00063.2007 · Cited by 92
Self-citationPericyte mechanics and mechanobiology
Dessalles, C. A., Babataheri, A., & Barakat, A. I. (2021) · Journal of Cell Science · doi:10.1242/jcs.240226 · Cited by 99
“The interstitial pressure forces to which pericytes are subjected are expected to be different for each subtype because of the differences in localization; the pressure is estimated at ∼50 mmHg for ePCs, ∼30 mmHg for tsPCs and ∼15 mmHg for sPCs (Parazynski et al., 1993; Slaaf et al., 1987).”
BackgroundKuller, L. H., Arnold, A. M., Longstreth, W. T., Jr., Manolio, T. A., O’Leary, D. H., Burke, G. L., Fried, L. P., & Newman, A. B. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.010 · Cited by 92
Implications of Vascular Aging
Barodka, V. M., Joshi, B. L., Berkowitz, D. E., Hogue, C. W. J., & Nyhan, D. P. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3182147e3c · Cited by 93
Cerebral blood flow changes during aging process and in cognitive disorders: A review
Mokhber, N., Shariatzadeh, A., Avan, A., Saber, H., Babaei, G., Chaimowitz, G. A., & Azarpazhooh, M. R. (2021) · The Neuroradiology Journal · doi:10.1177/19714009211002778 · Cited by 97
“Theoretically, such a pulsatile energy might lead to cerebral microvascular disease, and consequently cognitive impairment.(48) However, this association was not confirmed in a TCD study.”
BackgroundMechanisms and consequences of salt sensitivity and dietary salt intake
Kanbay, M., Chen, Y., Solak, Y., & Sanders, P. W. (2010) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e32834122f1 · Cited by 88
Arterial stiffness in health and disease: The role of cardio–ankle vascular index
Miyoshi, T., & Ito, H. (2021) · Journal of Cardiology · doi:10.1016/j.jjcc.2021.07.011 · Cited by 86
Pulse Wave Velocity as a Marker of Cognitive Impairment in the Elderly
Scuteri, A., & Wang, H. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141416 · Cited by 88
“blood from the heart to the peripheral organs and a heart level into a steady state blood supply at peripheral level) [21].”
Farasat, S. M., Morrell, C. H., Scuteri, A., Ting, C.-T., Yin, F. C. P., Spurgeon, H. A., Chen, C.-H., Lakatta, E. G., & Najjar, S. S. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.099515 · Cited by 84
The association between cerebral atherosclerosis and arterial stiffness in acute ischemic stroke
Kim, J., Cha, M.-J., Lee, D. H., Lee, H. S., Nam, C. M., Nam, H. S., Kim, Y. D., & Heo, J. H. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.09.013 · Cited by 85
Vitamin D and the Risk of Dementia: The Rotterdam Study
Licher, S., de Bruijn, R. F. A. G., Wolters, F. J., Zillikens, M. C., Ikram, M. A., & Ikram, M. K. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170407 · Cited by 88
Chronic kidney disease‐related physical frailty and cognitive impairment: a systemic review
Shen, Z., Ruan, Q., Yu, Z., & Sun, Z. (2016) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12758 · Cited by 84
Rosano, C., Watson, N. L., Chang, Y., Newman, A. B., Aizenstein, H. J., Du, Y., Venkatraman, V. K., Harris, T. B., Barinas‐Mitchell, E., & Sutton-Tyrrell, K. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.198069 · Cited by 88
“160 Stiffness of the central arteries is an important determinant of microvascular injury in aging and hypertension.(1,2) Potential cognitive and renal consequences of arterial stiffness(3,4) may reflect gradual loss of the cushioning capacity of the aorta and subsequent transmission of damaging flow pulsations to the…”
Blood Pressure Variability and Dementia: A State-of-the-Art Review
Ma, Y., Tully, P. J., Albert Hofman, D., & Tzourio, C. (2020) · American Journal of Hypertension · doi:10.1093/ajh/hpaa119 · Cited by 86
Yambe, M., Tomiyama, H., Yamada, J., Koji, Y., Motobe, K., Shiina, K., Yamamoto, Y., & Yamashina, A. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000254375.73241.e2 · Cited by 82
Bénétos, A., Watfa, G., Hanon, O., Salvi, P., Fantin, F., Toulza, O., Manckoundia, P., Agnoletti, D., Labat, C., & Gautier, S. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2010.08.014 · Cited by 82
Bouchi, R., Babazono, T., Mugishima, M., Yoshida, N., Nyumura, I., Toya, K., Hanai, K., Tanaka, N., Ishii, A., Uchigata, Y., et al. (2011) · Diabetes Care · doi:10.2337/dc11-1020 · Cited by 82
“Therefore, the stiffening of large arteries may directly increase pulsatile stress, especially in these vessels because of increased aortic characteristic impedance and early return of wave reflection and could cause glomerular and/or tubular damage via increased intrarenal pulse pressure (22), possibly leading to mic…”
BackgroundArterial Stiffness and Diabetes Risk in Framingham Heart Study and UK Biobank
Cohen, J. B., Mitchell, G. F., Gill, D., Burgess, S., Rahman, M., Hanff, T. C., Vasan, R. S., Mutalik, K. M., Townsend, R. R., & Chirinos, J. A. (2022) · Circulation Research · doi:10.1161/circresaha.122.320796 · Cited by 89
Lammers, S. R., Scott, D. E., Hunter, K. S., Tan, W., Shandas, R., & Stenmark, K. R. (2012) · Comprehensive physiology · doi:10.1002/cphy.c100070 · Cited by 90
Kidney disease as a determinant of cognitive decline and dementia
Etgen, T. (2015) · Alzheimer s Research & Therapy · doi:10.1186/s13195-015-0115-4 · Cited by 80
“The kidney and the brain possess a similar low vascular resistance system allowing continuous high-volume perfusion, which makes both organs vulnerable to microvascular injury caused by hypertension and diabetes [6].”
BackgroundPulse Wave Velocity and Cognitive Function in Older Adults
Zhong, W., Cruickshanks, K. J., Schubert, C. R., Carlsson, C. M., Chappell, R. J., Klein, R., Klein, R., & Acher, C. W. (2013) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3182949f06 · Cited by 79
The role of insulin in the vascular contributions to age-related dementia
Hughes, T. M., & Craft, S. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.013 · Cited by 84
Lizarelli, P. M., Martins, W. P., Vieira, C. S., Soares, G. M., Franceschini, S. A., Ferriani, R. A., & Patta, M. C. (2008) · Contraception · doi:10.1016/j.contraception.2008.07.024 · Cited by 78
“Considering the long latent phase of atherosclerotic progression before symptoms are manifested, the ability to evaluate arterial function prior to the development of an angiographically measurable atherosclerotic plaque is an important aspect of early detection and risk classification [9–11].”
BackgroundTriantafyllidi, H., Arvaniti, C., Lekakis, J. P., Ikonomidis, I., Siafakas, N., Tzortzis, S., Trivilou, P., Zerva, L., Stamboulis, E., & Kremastinos, D. T. (2009) · American Journal of Hypertension · doi:10.1038/ajh.2009.35 · Cited by 78
Kidney Function and Cerebral Small Vessel Disease in the General Population
Akoudad, S., Sedaghat, S., Albert Hofman, D., Koudstaal, P. J., van der Lugt, A., Ikram, M. A., & Vernooij, M. W. (2015) · International Journal of Stroke · doi:10.1111/ijs.12465 · Cited by 76
Sehgal, A., Gwini, S. M., Menahem, S., Allison, B. J., Miller, S., & Polglase, G. R. (2018) · The Journal of Physiology · doi:10.1113/jp276040 · Cited by 76
Caruso, P., Signori, R., & Moretti, R. (2019) · Vascular Health and Risk Management · doi:10.2147/vhrm.s190470 · Cited by 78
“The brain usually has a high resting flow which seems to be related to the fact that heart pulsation (plus the Windkessel effect) produces a higher perfusion pressure toward the most profound small arteries of the brain.(146,147)”
BackgroundArterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet
Alastruey, J., Charlton, P. H., Bikia, V., Paliakaitė, B., Hametner, B., Bruno, R. M., Mulder, M. P., Vennin, S., Pişkin, Ş., Khir, A. W., et al. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00705.2022 · Cited by 87
Nelson, A. J., Worthley, S. G., Cameron, J. D., Willoughby, S. R., Piantadosi, C., Carbone, A., Dundon, B. K., Leung, M., Hope, S. A., Meredith, I. T., et al. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32831e4599 · Cited by 75
Triantafyllou, Α., Anyfanti, P., Gavriilaki, E., Zabulis, X., Gkaliagkousi, Ε., Petidis, K., Triantafyllou, G. A., Gkolias, V., Pyrpasopoulou, A., & Δούμα, Σ. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu074 · Cited by 75
Chronic Kidney Disease in Patients With Lacunar Stroke
Xiao, L., Lan, W., Sun, W., Dai, Q., Xiong, Y., Li, L., Zhou, Y., Zheng, P., Fan, W., Ma, N., et al. (2015) · Stroke · doi:10.1161/strokeaha.114.008155 · Cited by 74
Prognostic Importance of Serum Alkaline Phosphatase in CKD Stages 3-4 in a Clinical Population
Taliercio, J. J., Schold, J. D., Simon, J. F., Arrigain, S., Tang, A., Saab, G., Nally, J. V., & Navaneethan, S. D. (2013) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2013.04.012 · Cited by 74
Metadata
- Authors
- O’Rourke, M. F., & Safar, M. E.
- Affiliations
- UNSW Sydney (AU)
- Venue
- Hypertension
- Published
- 2005-07
- Volume
- 46
- Issue
- 1
- Pages
- 200-204
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2103868761
- Cited by
- 1,279
- References
- 43
- Citations by year
- 2026: 33 · 2025: 65 · 2024: 56 · 2023: 50 · 2022: 62 · 2021: 73 · 2020: 74 · 2019: 67 · 2018: 98 · 2017: 67 · 2016: 84 · 2015: 80 · 2014: 91 · 2013: 59 · 2012: 63
- FWCI
- 19.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Nephrology › Renal and Vascular Pathologies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- aortic stiffness, microangiopathy, central pulse pressure, aortic pulse wave velocity, augmentation index, input impedance, wave reflection, aging, renal failure, cognitive decline, diabetes mellitus, vascular fragility, nitrate, calcium channel blockers, ACE inhibitors, angiotensin receptor blockers, physical activity
- MeSH terms
- Aorta, Brain, Compliance, Humans, Kidney, Microcirculation, Vascular Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
