The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Retinal Vessel Diameters and Risk of Hypertension: The Rotterdam Study
Open accessAbstract
Generalized retinal arteriolar narrowing is an important sign of systemic hypertension, and a lower arteriolar:venular diameter ratio predicts the risk of hypertension. We investigated whether this association was based on arteriolar or venular diameters or both. This study was based on the prospective population-based Rotterdam Study (1990–1993) and included 1900 participants (≥55 years of age) of whom 739 persons had normal blood pressure (systolic <120 mm Hg and diastolic <80 mm Hg) and 1161 prehypertension (systolic 120 to 139 mm Hg or diastolic 80 to 89 mm Hg). For each participant, retinal arteriolar and venular diameters were measured on digitized images of 1 eye. After a mean follow-up of 6.6 years, 808 persons developed hypertension, defined as either systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg or use of antihypertensive medication. Adjusted for age, gender, follow-up time, body mass index, smoking, diabetes mellitus, total and high-density lipoprotein cholesterol, C-reactive protein, and intima-media thickness, arteriolar narrowing was associated with an increased risk of hypertension (odds ratio per SD: 1.38; 95% CI, 1.23 to 1.55); for venular narrowing this was less striking (OR: 1.17; 95% CI, 1.04 to 1.32). Each SD decrease in the arteriolar:venular diameter ratio significantly increased the risk of hypertension by 24%. To examine the effect of baseline blood pressure, we stratified persons into those with “normal blood pressure” or “prehypertension.” Within these strata, arteriolar narrowing was still related to incident hypertension. These data show that both retinal arteriolar and venular narrowing may precede the development of systemic hypertension.
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Chobanian, A. V. (2003) · JAMA · doi:10.1001/jama.289.19.2560 · Cited by 25,386
Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L., Jones, D. W., Materson, B. J., Oparil, S., Wright, J. T., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000107251.49515.c2 · Cited by 13,271
Hubbard, L. D., Brothers, R. J., King, W. N., Clegg, L. X., Klein, R., Cooper, L. S., Sharrett, A. R., Davis, M. D., & Cai, J. (1999) · Ophthalmology · doi:10.1016/s0161-6420(99)90525-0 · Cited by 1,184
Determinants of disease and disability in the elderly: The Rotterdam elderly study
Hofman, A., Grobbee, D. E., De Jong, P. T. V. M., & Van den Ouweland, F. A. (1991) · European Journal of Epidemiology · doi:10.1007/bf00145007 · Cited by 1,129
Self-citationRevised formulas for summarizing retinal vessel diameters
Knudtson, M. D., Lee, K. E., Hubbard, L. D., Wong, T. Y., Klein, R., & Klein, B. E. K. (2003) · Current Eye Research · doi:10.1076/ceyr.27.3.143.16049 · Cited by 872
Oparil, S., Zaman, M. A., & Calhoun, D. A. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-9-200311040-00011 · Cited by 680
Microcirculation in Hypertension: A New Target for Treatment?
Levy, B. I., Ambrosio, G., Pries, A. R., & Struijker-Boudier, H. A. J. (2001) · Circulation · doi:10.1161/hc3101.091158 · Cited by 637
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Schlaich, M. P., Lambert, E., Kaye, D. M., Krozowski, Z., Campbell, D. J., Lambert, G., Hastings, J., Aggarwal, A., & Esler, M. D. (2004) · Hypertension · doi:10.1161/01.hyp.0000103160.35395.9e · Cited by 514
Ikram, M. K., de Jong, F. J., Vingerling, J. R., Witteman, J. C. M., Hofman, A., Breteler, M. M. B., & de Jong, P. T. V. M. (2004) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.03-1390 · Cited by 501
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Retinal vascular biomarkers for early detection and monitoring of Alzheimer’s disease
Frost, S., Kanagasingam, Y., Sohrabi, H., Vignarajan, J., Bourgeat, P., Salvado, O., Villemagne, V, Rowe, C. C., Lance Macaulay, S., Szoeke, C., et al. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.150 · Cited by 297
Quantitative and qualitative retinal microvascular characteristics and blood pressure
Cheung, C. Y., Tay, W. T., Mitchell, P., Wang, J. J., Hsu, W., Lee, M. L., Lau, Q. P., Zhu, A. L., Klein, R., Saw, S. M., et al. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e328347266c · Cited by 255
The Rotterdam Study: 2010 objectives and design update
Hofman, A., Breteler, M. M. B., van Duijn, C. M., Janssen, H. L. A., Krestin, G. P., Kuipers, E. J., Stricker, B. H. C., Tiemeier, H., Uitterlinden, A. G., Vingerling, J. R., et al. (2009) · European Journal of Epidemiology · doi:10.1007/s10654-009-9386-z · Cited by 244
Self-citationRetinal Vascular Changes in Pre-Diabetes and Prehypertension
Nguyen, T. T., Wang, J. J., & Wong, T. Y. (2007) · Diabetes Care · doi:10.2337/dc07-0732 · Cited by 237
Aortic Distensibility and Retinal Arteriolar Narrowing: The Multi-Ethnic Study of Atherosclerosis
Cheung, N., Sharrett, A. R., Klein, R., Criqui, M. H., Islam, F. M. A., Macura, K. J., Cotch, M. F., Klein, B. E. K., & Wong, T. Y. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.091926 · Cited by 124
Metadata
- Authors
- Ikram, M. K., Witteman, J. C. M., Vingerling, J. R., Breteler, M. M. B., Hofman, A., & de Jong, P. T. V. M.
- Venue
- Hypertension
- Published
- 2006-02
- Volume
- 47
- Issue
- 2
- Pages
- 189-194
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2122639624
- Cited by
- 339
- References
- 26
- FWCI
- 9.28
- Type
- journal article
- Language
- en
- Open access
- green
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- Ikram, M. K., Witteman, J. C. M., Vingerling, J. R., Breteler, M. M. B., Hofman, A., & de Jong, P. T. V. M. (2006). Retinal Vessel Diameters and Risk of Hypertension: The Rotterdam Study. Hypertension. https://doi.org/10.1161/01.hyp.0000199104.61945.33
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