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Cited by 79Cardiovascular Function and Risk FactorsCardiac Fibrosis and RemodelingFatty Acid Research and Health

HIGH‐FAT DIET PREVENTS CARDIAC HYPERTROPHY AND IMPROVES CONTRACTILE FUNCTION IN THE HYPERTENSIVE DAHL SALT‐SENSITIVE RAT

Okere, Isidore C, Chess, David J, McElfresh, Tracy A, Johnson, Janean, Rennison, Julie, Ernsberger, Paul, Hoit, Brian D, Chandler, Margaret P +1 more·2005·Clinical and Experimental Pharmacology and Physiology
DOI 10.1111/j.1440-1681.2005.04272.x
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Abstract

SUMMARY: 1. The role that dietary lipid and plasma fatty acid concentration play in the development of cardiac hypertrophy in response to hypertension is not clear. 2. In the present study, we treated Dahl salt‐sensitive rats with either normal chow (NC), normal chow with salt added (NC + salt) or a diet high in long‐chain saturated fatty acids with added salt (HFD + salt). Cardiac function was assessed by echocardiography and left ventricular (LV) catheterization. 3. The HFD + salt group had significantly higher plasma free fatty acid concentrations and myocardial triglyceride content compared with the NC + salt group, but did not upregulate the activity of the fatty acid oxidation enzyme medium chain acyl‐coenzyme A dehydrogenase. Systolic blood pressure was elevated to a similar extent in the NC + salt and HFD + salt groups compared with the NC group. Although LV mass was increased in the NC + salt group compared with the NC group, LV mass in the HFD + salt group did not differ from that of the NC group and was significantly lower than that in the NC + salt group. 4. There was no evidence of cardiac dysfunction in the NC + salt group compared with the NC group; however, high fat feeding significantly increased LV contractile performance (e.g. increased cardiac output and peak dP/dt). 5. In conclusion, the HFD + salt diet prevented the hypertrophic response to hypertension and improved the contractile performance of the heart. It remains to be determined whether preventing cardiac hypertrophic adaptations would be deleterious to the heart if the hypertensive stress is maintained long term.

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Crossref · 10.1111/j.1440-1681.2005.04272.x

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  • Isocaloric high-fat diets that are associated with reduced levels of insulin and leptin appear to attenuate LV hypertrophy in pressure overload hypertrophy and minimize LV remodeling in a rat infarct model.

    “For example, isocaloric high-fat diets that are associated with reduced levels of insulin and leptin appear to attenuate LV hypertrophy in pressure overload hypertrophy and minimize LV remodeling in a rat infarct model (239, 261, 262).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [261]

  • Isocaloric high-fat diets that do not lead to hyperinsulinemia or weight gain seem to attenuate pressure overload LVH.

    “Also, isocaloric high-fat diets that do not lead to hyperinsulinemia or weight gain seem to attenuate pressure overload LVH (261, 262).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [261]

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Authors
Okere, I. C., Chess, D. J., McElfresh, T. A., Johnson, J., Rennison, J., Ernsberger, P., Hoit, B. D., Chandler, M. P., & Stanley, W. C.
Affiliations
Case Western Reserve University (US)
Corresponding author
Stanley, William C
ORCID
Venue
Clinical and Experimental Pharmacology and Physiology
Publisher
Wiley
Published
2005-09-19
Volume
32
Issue
10
Pages
825-831
ISSN
  • 0305-1870 (ISSN-L)
  • 1440-1681
DOI
10.1111/j.1440-1681.2005.04272.x
OpenAlex
W2032428545
Cited by
79
References
37
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 7
FWCI
4.10
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical and Experimental Pharmacology and Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (HL 074237, P01HL074237)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
high-fat diet, cardiac hypertrophy, hypertension, Dahl salt-sensitive rats, left ventricular contractility, plasma free fatty acids, myocardial triglycerides, medium-chain acyl-CoA dehydrogenase, fatty acid oxidation, dietary saturated fatty acids, salt loading, left ventricular mass
MeSH terms
Animals, Blood Pressure, Dietary Fats, Electrocardiography, Fatty Acids, Nonesterified, Cardiomegaly, Heart Ventricles, Hypertension, Male, Myocardial Contraction, Myocardium, Organ Size, Triglycerides, Sodium Chloride, Dietary, Rats, Inbred Dahl, Body Size, Rats

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