The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Angiotensin II Increases Vascular Permeability Factor Gene Expression by Human Vascular Smooth Muscle Cells
Abstract
Abstract Angiotensin II (Ang II) has been implicated in the pathogenesis of the vascular injury associated with hypertension and diabetes mellitus. Increased vascular permeability is an important early manifestation of endothelial dysfunction and the pathogenesis of atherosclerosis. How Ang II contributes to endothelial dysfunction and promotes an increase in vascular permeability is unknown but is classically attributed to its pressor actions. We demonstrate that human vascular smooth muscle cells express abundant mRNA for vascular permeability/endothelial growth factor. Vascular permeability factor is a 34- to 42-kD glycoprotein that markedly increases vascular endothelial permeability and is a potent endothelial mitogen. Ang II potently induced a concentration-dependent (maximal, 10−7 mol/L) and time-dependent increase in vascular permeability factor mRNA expression by human vascular smooth muscle cells that was maximal after 3 hours and diminished by 24 hours. Ang II–induced vascular permeability factor mRNA expression by human vascular smooth muscle cells was inhibited by the specific Ang II receptor antagonist losartan (DuP 753), confirming that this is an Ang II receptor subtype 1–mediated event. These results describe a new action of Ang II on human vascular smooth muscle, notably the induction of vascular permeability factor mRNA expression. The wide spectrum and potent activity of vascular permeability factor suggest a novel mechanism whereby Ang II could locally and directly influence the permeability, growth, and function of the vascular endothelium independent of changes in hemodynamics.
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Cites
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Cited by
Role of the Microvascular Endothelium in Progressive Renal Disease
Kang, D.-H., Kanellis, J., Hugo, C., Truong, L., Anderson, S., Kerjaschki, D., Schreiner, G. F., & Johnson, R. J. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v133806 · Cited by 466
Proinflammatory actions of angiotensins
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Proinflammatory functions of vascular endothelial growth factor in alloimmunity
Reinders, M. E. J., Sho, M., Izawa, A., Wang, P., Mukhopadhyay, D., Koss, K. E., Geehan, C. S., Luster, A. D., Sayegh, M. H., & Briscoe, D. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17712 · Cited by 251
Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation
Bekassy, Z., Lopatko Fagerström, I., Bader, M., & Karpman, D. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-021-00634-8 · Cited by 167
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Metadata
- Authors
- Williams, B., Baker, A. Q., Gallacher, B., & Lodwick, D.
- Venue
- Hypertension
- Published
- 1995-05
- Volume
- 25
- Issue
- 5
- Pages
- 913-917
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W1973898220
- Cited by
- 301
- References
- 31
- FWCI
- 7.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Angiotensin II Increases Vascular Permeability Factor Gene Expression by Human Vascular Smooth Muscle Cells. https://app.cochat.ai/papers/10.1161/01.hyp.25.5.913
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- Williams, B., Baker, A. Q., Gallacher, B., & Lodwick, D. (1995). Angiotensin II Increases Vascular Permeability Factor Gene Expression by Human Vascular Smooth Muscle Cells. Hypertension. https://doi.org/10.1161/01.hyp.25.5.913
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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