The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Role of Endothelin in the Increased Vascular Tone of Patients With Essential Hypertension
Open accessAbstract
Abstract—We investigated the possible role of endothelin in the increased vasoconstrictor tone of hypertensive patients using antagonists of endothelin receptors. Forearm blood flow (FBF) responses (strain-gauge plethysmography) to intraarterial infusion of blockers of endothelin-A (ET A) (BQ-123) and endothelin-B (ET B) (BQ-788) receptors, separately and in combination, were measured in hypertensive patients and normotensive control subjects. In healthy subjects, BQ-123 alone or in combination with BQ-788 did not significantly modify FBF (P=0.78 and P=0.63, respectively). In hypertensive patients, in contrast, BQ-123 increased FBF by 33±7% (P<0.001 versus baseline), and the combination of BQ-123 and BQ-788 resulted in a greater vasodilator response (63±12%;P=0.006 versus BQ-123 alone in the same subjects). BQ-788 produced a divergent vasoactive effect in the two groups, with a decrease of FBF (17±5%;P=0.004 versus baseline) in control subjects and transient vasodilation (15±7% after 20 minutes) in hypertensive patients (P<0.001, hypertensives versus controls). The vasoconstrictor response to endothelin-1 was slightly higher (P=0.04) in hypertensive patients (46±4%) than in control subjects (32±4%). Our data indicate that patients with essential hypertension have increased vascular endothelin activity, which may be of pathophysiological relevance to their increased vascular tone. In these patients, nonselective ET A and ET B blockade seems to produce a greater vasodilator effect than selective ET A blockade.
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Cites
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Cited by
Channick, R. N., Simonneau, G., Sitbon, O., Robbins, I. M., Frost, A., Tapson, V. F., Badesch, D. B., Roux, S., Rainisio, M., Bodin, F., et al. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06250-x · Cited by 1,534
Brook, R. D., Brook, J. R., Urch, B., Vincent, R., Rajagopalan, S., & Silverman, F. (2002) · Circulation · doi:10.1161/01.cir.0000013838.94747.64 · Cited by 845
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)
Félétou, M., & Vanhoutte, P. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00292.2006 · Cited by 818
Davenport, A. P., Hyndman, K. A., Dhaun, N., Southan, C., Kohan, D. E., Pollock, J. S., Pollock, D. M., Webb, D. J., & Maguire, J. J. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011833 · Cited by 772
Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist
Iglarz, M., Binkert, C., Morrison, K., Fischli, W., Gatfield, J., Treiber, A., Weller, T., Bolli, M. H., Boss, C., Buchmann, S., et al. (2008) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.142976 · Cited by 329
Metadata
- Authors
- Cardillo, C., Kilcoyne, C. M., Waclawiw, M., Cannon, R. O., & Panza, J. A.
- Venue
- Hypertension
- Published
- 1999-02
- Volume
- 33
- Issue
- 2
- Pages
- 753-758
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2114778001
- Cited by
- 285
- References
- 30
- FWCI
- 10.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cardillo, C., Kilcoyne, C. M., Waclawiw, M., Cannon, R. O., & Panza, J. A. (1999). Role of Endothelin in the Increased Vascular Tone of Patients With Essential Hypertension. Hypertension. https://doi.org/10.1161/01.hyp.33.2.753
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