Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults
Abstract
BACKGROUND: Fine particulate air pollution and ozone are associated with increased cardiovascular events. To help explain the mechanism behind these observations, we investigated the effect of air pollution exposure on vascular function. METHODS AND RESULTS: Twenty-five healthy adults underwent a randomized, double-blind, crossover study comparing the vascular response to the 2-hour inhalation of approximately 150 microg/m(3) of concentrated ambient fine particles (CAP) plus ozone (120 ppb) versus the response to the inhalation of filtered air. High-resolution vascular ultrasonography was used to measure alterations in brachial artery diameter, endothelial-dependent flow-mediated dilatation (FMD) and endothelial-independent nitroglycerin-mediated dilatation (NMD). Exposure to CAP plus ozone caused a significant brachial artery vasoconstriction compared with filtered air inhalation (-0.09+/-0.15 mm versus +0.01+/-0.18 mm, P=0.03). There were no significant differences in FMD (+0.29+/-4.11% versus -0.03+/-6.63%, P=0.88), NMD (+3.87+/-5.43% versus +3.46+/-7.92%, P=0.83), or blood pressure responses between exposures. CONCLUSIONS: Short-term inhalation of fine particulate air pollution and ozone at concentrations that occur in the urban environment causes acute conduit artery vasoconstriction.
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Disability adjusted life years lost attributable to ozone were estimated to be 6.3 ± 3.0 million years in 2000.
“Disability adjust life years (DALY) lost attributable to ozone were estimated to be 6.3 ± 3.0 million years in 2000 (58)”
From Ozone pollution: A Major health hazard worldwide (2019) · cites this paper as [58]
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- Authors
- Brook, R. D., Brook, J. R., Urch, B., Vincent, R., Rajagopalan, S., & Silverman, F.
- Affiliations
- Health Canada (CA)
- Venue
- Circulation
- Published
- 2002-04-02
- Volume
- 105
- Issue
- 13
- Pages
- 1534-1536
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2066878158
- Cited by
- 845
- References
- 20
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 16 · 2023: 32 · 2022: 29 · 2021: 39 · 2020: 39 · 2019: 28 · 2018: 30 · 2017: 34 · 2016: 37 · 2015: 37 · 2014: 31 · 2013: 35 · 2012: 44
- FWCI
- 28.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Government of Canada
- Health Canada
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- PM2.5, ozone, air pollution, arterial vasoconstriction, brachial artery, flow-mediated dilation, endothelial function, vascular function, cardiovascular risk, urban air pollution
- MeSH terms
- Adult, Air Pollutants, Air Pollution, Arteries, Brachial Artery, Double-Blind Method, Female, Humans, Male, Ozone, Particle Size, Ultrasonography, Vasoconstriction, Vasodilation, Cross-Over Studies, Inhalation Exposure
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