The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Protein Glycation: A Firm Link to Endothelial Cell Dysfunction
Abstract
The advanced glycation end products (AGEs) are a heterogeneous class of molecules, including the following main subgroups: bis(lysyl)imidazolium cross-links, hydroimidazolones, 3-deoxyglucosone derivatives, and monolysyl adducts. AGEs are increased in diabetes, renal failure, and aging. Microvascular lesions correlate with the accumulation of AGEs, as demonstrated in diabetic retinopathy or renal glomerulosclerosis. On endothelial cells, ligation of receptor for AGE (RAGE) by AGEs induces the expression of cell adhesion molecules, tissue factor, cytokines such as interleukin-6, and monocyte chemoattractant protein-1. A chief means by which AGEs via RAGE exert their effects is by generation of reactive oxygen species, at least in part via stimulation of NADPH oxidase. Diabetes-associated vascular dysfunction in vivo can be prevented by blockade of RAGE. Thus, agents that limit AGE formation, increase the catabolism of these species, or antagonize their binding to RAGE may provide new targets for vascular protection in diabetes.
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Cites
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Hammes, H.-P., Du, X., Edelstein, D., Taguchi, T., Matsumura, T., Ju, Q., Lin, J., Bierhaus, A., Nawroth, P., Hannak, D., et al. (2003) · Nature Medicine · doi:10.1038/nm834 · Cited by 785
New Markers of Inflammation and Endothelial Cell Activation: Part I
Szmitko, P. E., Wang, C.-H., Weisel, R. D., de Almeida, J. R., Anderson, T. J., & Verma, S. (2003) · Circulation · doi:10.1161/01.cir.0000089190.95415.9f · Cited by 738
YONEKURA, H., YAMAMOTO, Y., SAKURAI, S., PETROVA, R. G., ABEDIN, M. J., LI, H., YASUI, K., TAKEUCHI, M., MAKITA, Z., TAKASAWA, S., et al. (2003) · Biochemical Journal · doi:10.1042/bj20021371 · Cited by 716
Negative consequences of glycation
Brownlee, M. (2000) · Metabolism · doi:10.1016/s0026-0495(00)80078-5 · Cited by 284
Ahmed, N., & Thornalley, P. J. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311417 · Cited by 152
Cited by
Oxidative stress and diabetic complications
Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461
Protein Glycosylation in Cancer
Stowell, S. R., Ju, T., & Cummings, R. D. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040438 · Cited by 873
Ramasamy, R., Vannucci, S. J., Yan, S. S. D., Herold, K., Yan, S. F., & Schmidt, A. M. (2005) · Glycobiology · doi:10.1093/glycob/cwi053 · Cited by 834
Self-citationArterial Aging: Is It an Immutable Cardiovascular Risk Factor?
Najjar, S. S., Scuteri, A., & Lakatta, E. G. (2005) · Hypertension · doi:10.1161/01.hyp.0000177474.06749.98 · Cited by 640
Oxidative stress and diabetes: antioxidative strategies
Zhang, P., Li, T., Wu, X., Nice, E. C., Huang, C., & Zhang, Y. (2020) · Frontiers of Medicine · doi:10.1007/s11684-019-0729-1 · Cited by 513
Metadata
- Authors
- Wautier, J.-L., & Schmidt, A. M.
- Venue
- Circulation Research
- Published
- 2004-08-06
- Volume
- 95
- Issue
- 3
- Pages
- 233-238
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2163647109
- Cited by
- 436
- References
- 6
- FWCI
- 17.02
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
