Cited by 786Cardiac Fibrosis and RemodelingTGF-β signaling in diseasesNitric Oxide and Endothelin Effects

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NAD(P)H Oxidase 4 Mediates Transforming Growth Factor-β1–Induced Differentiation of Cardiac Fibroblasts Into Myofibroblasts

Cucoranu, Ioan, Clempus, Roza, Dikalova, Anna, Phelan, Patrick J., Ariyan, Srividya, Dikalov, Sergey, Sorescu, Dan·2005·Circulation Research

DOI 10.1161/01.res.0000187457.24338.3d

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Abstract

Human cardiac fibroblasts are the main source of cardiac fibrosis associated with cardiac hypertrophy and heart failure. Transforming growth factor-β1 (TGF-β1) irreversibly converts fibroblasts into pathological myofibroblasts, which express smooth muscle α-actin (SM α-actin) de novo and produce extracellular matrix. We hypothesized that TGF-β1–stimulated conversion of fibroblasts to myofibroblasts requires reactive oxygen species derived from NAD(P)H oxidases (Nox). We found that TGF-β1 potently upregulates the contractile marker SM α-actin mRNA (7.5±0.8-fold versus control). To determine whether Nox enzymes are involved, we first performed quantitative real time polymerase chain reaction and found that Nox5 and Nox4 are abundantly expressed in cardiac fibroblasts, whereas Nox1 and Nox2 are barely detectable. On stimulation with TGF-β1, Nox4 mRNA is dramatically upregulated by 16.2±0.8-fold (n=3, P <0.005), whereas Nox5 is downregulated. Small interference RNA against Nox4 downregulates Nox4 mRNA by 80±5%, inhibits NADPH-driven superoxide production in response to TGF-β1 by 65±7%, and reduces TGF-β1–induced expression of SM α-actin by 95±2% (n=6, P <0.05). Because activation of small mothers against decapentaplegic (Smads) 2/3 is critical for myofibroblast conversion in response to TGF-β1, we also determined whether Nox4 affects Smad 2/3 phosphorylation. Depletion of Nox4 but not Nox5 inhibits baseline and TGF-β1 stimulation of Smad 2/3 phosphorylation by 75±5% and 68±3%, respectively (n=7, P <0.0001). We conclude that Nox 4 mediates TGF-β1–induced conversion of fibroblasts to myofibroblasts by regulating Smad 2/3 activation. Thus, Nox4 may play a critical role in the pathological activation of cardiac fibroblasts in cardiac fibrosis associated with human heart failure.

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Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., et al. (1995) · Nature Genetics · doi:10.1038/ng1295-376 · Cited by 1,789
Cell transformation by the superoxide-generating oxidase Mox1
Suh, Y.-A., Arnold, R. S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., Chung, A. B., Griendling, K. K., & Lambeth, J. D. (1999) · Nature · doi:10.1038/43459 · Cited by 1,480
Self-citation
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.
Reynisdóttir, I., Polyak, K., Iavarone, A., & Massagué, J. (1995) · Genes & Development · doi:10.1101/gad.9.15.1831 · Cited by 962
Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis
Sorescu, D., Weiss, D., Lassègue, B., Clempus, R. E., Szöcs, K., Sorescu, G. P., Valppu, L., Quinn, M. T., Lambeth, J. D., Vega, J. D., et al. (2002) · Circulation · doi:10.1161/01.cir.0000012917.74432.66 · Cited by 847
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Geiszt, M., Kopp, J. B., Várnai, P., & Leto, T. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130135897 · Cited by 840
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Lassègue, B., Sorescu, D., Szöcs, K., Yin, Q., Akers, M., Zhang, Y., Grant, S. L., Lambeth, J. D., & Griendling, K. K. (2001) · Circulation Research · doi:10.1161/hh0901.090299 · Cited by 839
Self-citation
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Ide, T., Tsutsui, H., Kinugawa, S., Utsumi, H., Kang, D., Hattori, N., Uchida, K., Arimura, K., Egashira, K., & Takeshita, A. (1999) · Circulation Research · doi:10.1161/01.res.85.4.357 · Cited by 702
TGF-?1 and angiotensin networking in cardiac remodeling
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Show all 41 references

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10.1161/res.86.2.119 · DOI
10.1161/circ.97.16.1536 · DOI
10.1161/circ.105.3.293 · DOI
10.1161/res.87.5.392 · DOI
10.1161/res.86.2.152 · DOI
10.1161/res.85.4.357 · DOI
10.1161/res.86.5.494 · DOI

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Phan, T. H. G., Posadino, A. M., Giordo, R., Fois, A. G., Pirina, P., Zinellu, A., Eid, A. H., & Pintus, G. (2025) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001764 · Cited by 3
The trilateral crosstalk of TGF β1-ROS-Nrf2 axis in fibrosis: Decoding mechanistic networks for precision therapeutics
Gao, Y., Yu, Q., Zhu, H., Zhang, Y., & Yang, H. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112327 · Cited by 3
Inhibitory Effects of 3′,4′‐Dihydroxyflavonol in a Rabbit Model of Minimally Invasive Bleb Surgery With PreserFlo MicroShunt
Pasvanis, Z., Kong, R. C. K., Chan, E. C., & Gaskin, J. C. F. (2025) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.14578 · Cited by 3
NOX4 Induces Oxidative Stress and Apoptosis Through Upregulation of Caspases 3 and 9 and Downregulation of TIGAR in HCV-infected Huh-7 Cells
Tariq, M., Manzoor, S., Ahmed, Q. L., Khalid, M., & Ashraf, W. (2013) · Future Virology · doi:10.2217/fvl.13.50 · Cited by 3
The Transforming Growth Factor-Beta (TGF-β) in Liver Fibrosis
Fabregat, I., & Sancho, P. (2013) · Springer eBooks · doi:10.1007/978-4-431-54409-8_11 · Cited by 3
The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool
Wegener, J. W., Wagdi, A., Wagner, E., Katschinski, D. M., Hasenfuss, G. P., Bruegmann, T., & Lehnart, S. E. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.777770 · Cited by 3
Diapocynin treatment induces functional and structural improvements in an advanced disease state in the mdx5Cv mice
Guedira, G., Petermann, O., Scapozza, L., & Ismail, H. M. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116957 · Cited by 3
Chemokine receptors and their ligands in breast cancer: The key roles in progression and metastasis
Valdivia‐Silva, J., & Chinney-Herrera, A. (2024) · International review of cytology · doi:10.1016/bs.ircmb.2024.07.002 · Cited by 3
Novel Insights Into the Role of Inflammation in Promoting Breast Cancer Development
Valdivia‐Silva, J., Franco‐Barraza, J., Cukierman, E., & Garcia-Zepe, E. A. (2011) · InTech eBooks · doi:10.5772/21699 · Cited by 3
Mechanisms by Which Manganese Porphyrins Affect Signaling in Cancer Cells
Oberley‐Deegan, R. E., & Crapo, J. D. (2016) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-319-30705-3_16 · Cited by 3
[Research progress of NADPH oxidases and their inhibitors].
Yang, X.-L., Chen, Y.-J., Hu, G., & Li, Q. (2016) · PubMed · Cited by 3
Duchenne cardiomyopathy: targeting ROS and NOX4 as a promising therapeutic strategy
Sampaolesi, M., Janssens, S. P., & Duelen, R. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2187287 · Cited by 3
Relationship between stress hyperglycemia ratio and the incidence of atrial fibrillation in patients after coronary artery bypass grafting: a retrospective study based on the MIMIC-IV database
Liu, R., Li, J., Zeng, J., Tao, Y., Chen, D., & Li, H. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01832-3 · Cited by 2
Obstructive Sleep Apnea: Epidemiology, Pathophysiology, Complications, Diagnosis, Management, and Emerging Fibrosis‐Linked Remodeling
Thuy, N. H. T., Phan, T. H. G., Eid, A. H., Maccioccu, P., Camboni, S., Casu, G., Posadino, A. M., Giordo, R., & Pintus, G. (2026) · MedComm · doi:10.1002/mco2.70877 · Cited by 2
Oxidative Stress in Cardiac Valve Development
Huk, D. J., & Lincoln, J. (2016) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4899-7693-2_1 · Cited by 2
Role of NADPH Oxidase in β Cell Dysfunction
Weaver, J. R., & Taylor, D. (2014) · Springer eBooks · doi:10.1007/978-94-007-6686-0_46 · Cited by 2
Cytoglobin-expressing cells in the splenic cords contribute to splenic fibrosis in cirrhotic patients.
Iimuro, Y., Yada, A., Okada, T., Nakamura, I., Suzumura, K., Xu, J., Sudo, M., Nishiguchi, S., Kawada, N., Hatano, E., et al. (2020) · PubMed · doi:10.14670/hh-18-257 · Cited by 2
NADPH Oxidase in Tissue Repair and Regeneration
Chan, E. C., Liu, G. S., Roulston, C. L., Lim, S. Y., & Dusting, G. J. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_97 · Cited by 3
Immunohistochemical Profile of VEGF, PGE 2 and TGF-β in Inflammatory Tenosynovitis of Carpal Tunnel Syndrome
Bianchi, E., Taurone, S., Leopizzi, M., Bardella, L., Liddo, R. D., Nucci, F., Pasture, F. S., Vitale, M., Mazzotti, A., & Artico, M. (2012) · European Journal of Inflammation · doi:10.1177/1721727x1201000325 · Cited by 2
Protection against Acute Pingyangmycin-induced Lung Injury: A novel Role for Low-dose Radiation
Yu, H., Liu, Z., Yu, X., Song, A., Liu, N., & Wang, H. (2013) · Cited by 2
Role of Oxidative Stress and Reactive Oxygen Radicals in the Pathogenesis of Systemic Sclerosis
Piera-Velázquez, S., & Jiménez, S. A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-6166-1_10 · Cited by 2
Key Cellular Effectors in ROS-Mediated Cardiac Diseases
Chaudhuri, R. D., Rana, S., Datta, K., & Sarkar, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-8946-7_7 · Cited by 2
Molecular, Gene, and Cellular Mechanism
Bradshaw, A. D., DeLeon‐Pennell, K. Y., & Menick, D. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-64067-1.00001-2 · Cited by 3
Non-coding RNAs Related to Atherosclerosis
Holvoet, P. (2021) · Springer eBooks · doi:10.1007/978-3-030-68844-8_5 · Cited by 2
Much ado about bone marrow stem cells: Role in post-myocardial infarct repair
Dixon, I. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.07.002 · Cited by 2
The aging cardiovascular system
Şener, Y. Z., & Canpolat, U. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-98804-9.00033-5 · Cited by 2
AMPK regulates the anti-pulmonary fibrosis effects of tracheloside
Siyuan, L., Qian, R., Xie, W., Miao, L., Huang, X., Deng, L., Xiong, D., Liu, W., & Tang, S. (2025) · Chinese Journal of Natural Medicines · doi:10.1016/j.cjnm.2025.100005 · Cited by 1
Nicotinamide adenine dinucleotide phosphate oxidase 4 in lung disease: a review of its biology and therapeutic potential
Wang, Y., Ben, T., Fang, J., Li, Z., Ding, J., Xu, L., Lin, K., & Jiang, L. (2026) · Experimental Biology and Medicine · doi:10.3389/ebm.2026.10941 · Cited by 2
Targeting Oxidative Stress in Heart Failure
Li, J. W. Y., & Tang, W. H. W. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_184 · Cited by 1
Patent Highlights December 2016–January 2017
Mucke, H. A. (2017) · Pharmaceutical Patent Analyst · doi:10.4155/ppa-2017-0007 · Cited by 1
Redox distress in organ fibrosis: The role of noncoding RNAs
Miguel, V., & Lamas, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-818606-0.00037-7 · Cited by 1
Nox4: From Discovery to Pathophysiology
Hecker, L., Kato, K., & Griendling, K. K. (2023) · Springer eBooks · doi:10.1007/978-3-031-23752-2_12 · Cited by 2
Aspects of Nox/Duox Signaling
Ushio‐Fukai, M. (2009) · Wiley eBooks · doi:10.1002/9783527627585.ch14 · Cited by 1
Antioxidants and inhibitors of flavoprotein‐dependent oxidases abrogate TGF‐beta induction of biglycan: Evidence for a role of reactive oxygen species
Ungefroren, H., Groth, S., & Fändrich, F. (2006) · Signal Transduction · doi:10.1002/sita.200600100 · Cited by 1
Oxidative Stress and Vascular Injury
Brahmbhatt, A. N., & Misra, S. (2016) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4899-7693-2_3 · Cited by 1

Authors: Cucoranu, I., Clempus, R., Dikalova, A., Phelan, P. J., Ariyan, S., Dikalov, S., & Sorescu, D.
Affiliations: Emory University (US)
ORCID: Dikalova, Anna
Phelan, Patrick J.
Dikalov, Sergey
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-10-28
Volume: 97
Issue: 9
Pages: 900-907
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/01.res.0000187457.24338.3d
OpenAlex: W2162514162
Cited by: 786
References: 41
Citations by year: 2026: 24 · 2025: 17 · 2024: 19 · 2023: 39 · 2022: 47 · 2021: 35 · 2020: 39 · 2019: 33 · 2018: 42 · 2017: 47 · 2016: 44 · 2015: 52 · 2014: 51 · 2013: 54 · 2012: 52
FWCI: 18.50
Type: journal article
Language: en
Open access: closed
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Institutes of Health
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: NOX4, cardiac fibroblasts, myofibroblast differentiation, TGF-β1, myocardial fibrosis, smooth muscle actin, reactive oxygen species, superoxide, Smad2/3 phosphorylation, heart failure, cardiac hypertrophy, extracellular matrix
MeSH terms: NADPH Oxidase 4, Actins, Cell Differentiation, Cells, Cultured, Fibroblasts, Fibrosis, Humans, Myocardium, RNA, Messenger, Superoxides, Transforming Growth Factor beta, Reactive Oxygen Species, Immediate-Early Proteins, NADPH Oxidases, Intercellular Signaling Peptides and Proteins, Smad2 Protein, Smad3 Protein, Transforming Growth Factor beta1, Connective Tissue Growth Factor

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NAD(P)H Oxidase 4 Mediates Transforming Growth Factor-β1–Induced Differentiation of Cardiac Fibroblasts Into Myofibroblasts

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