Cited by 786Cardiac Fibrosis and RemodelingTGF-β signaling in diseasesNitric Oxide and Endothelin Effects

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

NAD(P)H Oxidase 4 Mediates Transforming Growth Factor-β1–Induced Differentiation of Cardiac Fibroblasts Into Myofibroblasts

Cucoranu, Ioan, Clempus, Roza, Dikalova, Anna, Phelan, Patrick J., Ariyan, Srividya, Dikalov, Sergey, Sorescu, Dan·2005·Circulation Research

DOI 10.1161/01.res.0000187457.24338.3d

Open this paper in CoChat — free account

Abstract

Human cardiac fibroblasts are the main source of cardiac fibrosis associated with cardiac hypertrophy and heart failure. Transforming growth factor-β1 (TGF-β1) irreversibly converts fibroblasts into pathological myofibroblasts, which express smooth muscle α-actin (SM α-actin) de novo and produce extracellular matrix. We hypothesized that TGF-β1–stimulated conversion of fibroblasts to myofibroblasts requires reactive oxygen species derived from NAD(P)H oxidases (Nox). We found that TGF-β1 potently upregulates the contractile marker SM α-actin mRNA (7.5±0.8-fold versus control). To determine whether Nox enzymes are involved, we first performed quantitative real time polymerase chain reaction and found that Nox5 and Nox4 are abundantly expressed in cardiac fibroblasts, whereas Nox1 and Nox2 are barely detectable. On stimulation with TGF-β1, Nox4 mRNA is dramatically upregulated by 16.2±0.8-fold (n=3, P <0.005), whereas Nox5 is downregulated. Small interference RNA against Nox4 downregulates Nox4 mRNA by 80±5%, inhibits NADPH-driven superoxide production in response to TGF-β1 by 65±7%, and reduces TGF-β1–induced expression of SM α-actin by 95±2% (n=6, P <0.05). Because activation of small mothers against decapentaplegic (Smads) 2/3 is critical for myofibroblast conversion in response to TGF-β1, we also determined whether Nox4 affects Smad 2/3 phosphorylation. Depletion of Nox4 but not Nox5 inhibits baseline and TGF-β1 stimulation of Smad 2/3 phosphorylation by 75±5% and 68±3%, respectively (n=7, P <0.0001). We conclude that Nox 4 mediates TGF-β1–induced conversion of fibroblasts to myofibroblasts by regulating Smad 2/3 activation. Thus, Nox4 may play a critical role in the pathological activation of cardiac fibroblasts in cardiac fibrosis associated with human heart failure.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/01.res.0000187457.24338.3d

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886
Self-citation
How cells read TGF-β signals
Massagué, J. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043051 · Cited by 1,925
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., et al. (1995) · Nature Genetics · doi:10.1038/ng1295-376 · Cited by 1,789
Cell transformation by the superoxide-generating oxidase Mox1
Suh, Y.-A., Arnold, R. S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., Chung, A. B., Griendling, K. K., & Lambeth, J. D. (1999) · Nature · doi:10.1038/43459 · Cited by 1,480
Self-citation
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.
Reynisdóttir, I., Polyak, K., Iavarone, A., & Massagué, J. (1995) · Genes & Development · doi:10.1101/gad.9.15.1831 · Cited by 962
Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis
Sorescu, D., Weiss, D., Lassègue, B., Clempus, R. E., Szöcs, K., Sorescu, G. P., Valppu, L., Quinn, M. T., Lambeth, J. D., Vega, J. D., et al. (2002) · Circulation · doi:10.1161/01.cir.0000012917.74432.66 · Cited by 847
Self-citation
Identification of Renox, an NAD(P)H oxidase in kidney
Geiszt, M., Kopp, J. B., Várnai, P., & Leto, T. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130135897 · Cited by 840
Novel gp91 phox Homologues in Vascular Smooth Muscle Cells: nox1 Mediates Angiotensin II–Induced Superoxide Formation and Redox-Sensitive Signaling Pathways
Lassègue, B., Sorescu, D., Szöcs, K., Yin, Q., Akers, M., Zhang, Y., Grant, S. L., Lambeth, J. D., & Griendling, K. K. (2001) · Circulation Research · doi:10.1161/hh0901.090299 · Cited by 839
Self-citation
Mitochondrial Electron Transport Complex I Is a Potential Source of Oxygen Free Radicals in the Failing Myocardium
Ide, T., Tsutsui, H., Kinugawa, S., Utsumi, H., Kang, D., Hattori, N., Uchida, K., Arimura, K., Egashira, K., & Takeshita, A. (1999) · Circulation Research · doi:10.1161/01.res.85.4.357 · Cited by 702
TGF-?1 and angiotensin networking in cardiac remodeling
Rosenkranz, S. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.04.030 · Cited by 682

Show all 41 references

Research works printed but not linked: 7

10.1161/res.86.2.119 · DOI
10.1161/circ.97.16.1536 · DOI
10.1161/circ.105.3.293 · DOI
10.1161/res.87.5.392 · DOI
10.1161/res.86.2.152 · DOI
10.1161/res.85.4.357 · DOI
10.1161/res.86.5.494 · DOI

Sorted by citations

Items 301–400 of 784

Serotonin 5-HT 2B Receptor Blockade Prevents Reactive Oxygen Species–Induced Cardiac Hypertrophy in Mice
Monassier, L., Laplante, M., Jaffré, F., Bousquet, P., Maroteaux, L., & de Champlain, J. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.105551 · Cited by 56
Tumor-Resident Stromal Cells Promote Breast Cancer Invasion through Regulation of the Basal Phenotype
Hanley, C. J., Henriet, E., Sirka, O. K., Thomas, G. J., & Ewald, A. J. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0334 · Cited by 55
NOX as a Therapeutic Target in Liver Disease
Matuz‐Mares, D., Vázquez‐Meza, H., & Vilchis‐Landeros, M. M. (2022) · Antioxidants · doi:10.3390/antiox11102038 · Cited by 58
Ligand release-independent transactivation of epidermal growth factor receptor by transforming growth factor-β involves multiple signaling pathways
Joo, C.-K., Kim, H. S., Park, J.-Y., Seomun, Y., Son, M.-J., & Kim, J.-T. (2007) · Oncogene · doi:10.1038/sj.onc.1210649 · Cited by 55
Redox Signaling as a Therapeutic Target to Inhibit Myofibroblast Activation in Degenerative Fibrotic Disease
Sampson, N., Berger, P., & Zenzmaier, C. (2014) · BioMed Research International · doi:10.1155/2014/131737 · Cited by 55
TRPV1 Potentiates TGFβ-Induction of Corneal Myofibroblast Development through an Oxidative Stress-Mediated p38-SMAD2 Signaling Loop
Yang, Y., Wang, Z., Yang, H., Wang, L., Gillespie, S. R., Wolosin, J. M., Bernstein, A. M., & Reinach, P. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077300 · Cited by 55
NADPH Oxidases: New Regulators of Old Functions
Griendling, K. K. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1443 · Cited by 55
Transcriptional and phenotypic changes in aorta and aortic valve with aging and MnSOD deficiency in mice
Roos, C. M., Hagler, M., Zhang, B., Oehler, E. A., Arghami, A., & Miller, J. D. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00735.2012 · Cited by 54
More than a syllable in fib-ROS-is: The role of ROS on the fibrotic extracellular matrix and on cellular contacts
Grosche, J., Meißner, J., & Eble, J. A. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.03.005 · Cited by 53
Interstitial fluid flow and cyclic strain differentially regulate cardiac fibroblast activation via AT1R and TGF-β1
Galie, P. A., Russell, M. W. W., Westfall, M. V., & Stegemann, J. P. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.10.008 · Cited by 54
Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation
Ijaz, T., Jamaluddin, M., Zhao, Y., Zhang, Y., Jay, J. W., Finnerty, C. C., Herndon, D. N., Tilton, R. G., & Brasier, A. R. (2017) · Cell Death and Disease · doi:10.1038/cddis.2016.434 · Cited by 54
NADPH Oxidases in Diastolic Dysfunction and Heart Failure with Preserved Ejection Fraction
Teuber, J. P., Essandoh, K., Hummel, S. L., Madamanchi, N. R., & Brody, M. J. (2022) · Antioxidants · doi:10.3390/antiox11091822 · Cited by 55
The Nrf2 transcription factor: A multifaceted regulator of the extracellular matrix
Hiebert, P. (2021) · Matrix Biology Plus · doi:10.1016/j.mbplus.2021.100057 · Cited by 54
Docosahexaenoic Acid Inhibits UVB-Induced Activation of NF-κB and Expression of COX-2 and NOX-4 in HR-1 Hairless Mouse Skin by Blocking MSK1 Signaling
Rahman, M. M., Kundu, J. K., Shin, J.-W., Na, H., & Surh, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028065 · Cited by 52
A far-upstream AP-1/Smad binding box regulates human NOX4 promoter activation by transforming growth factor-β
Bai, G., Hock, T., Logsdon, N. J., Zhou, Y., & Thannickal, V. J. (2014) · Gene · doi:10.1016/j.gene.2014.02.026 · Cited by 52
The fate of the primary cilium during myofibroblast transition
Rozycki, M., Lodyga, M., Lam, J., Miranda, M. Z., Fátyol, K., Speight, P., & Kapùs, A. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-07-0429 · Cited by 53
Nox and Inflammation in the Vascular Adventitia
Meijles, D. N., & Pagano, P. J. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.03622 · Cited by 54
Therapeutic Potential of Polyphenols in Cardiac Fibrosis
Zhang, N., Wei, W., Li, L., Hu, C., & Tang, Q. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00122 · Cited by 55
Triggered Firing and Atrial Fibrillation in Transgenic Mice With Selective Atrial Fibrosis Induced by Overexpression of TGF-β1
Choi, E., Chang, P., Lee, Y.-S., Lin, S., Zhu, W., Maruyama, M., Fishbein, M. C., Chen, Z., Rubart, M., Field, L. J., et al. (2012) · Circulation Journal · doi:10.1253/circj.cj-11-1301 · Cited by 52
Alcohol-induced mitochondrial DNA damage promotes injurious crosstalk between alveolar epithelial cells and alveolar macrophages
Sadikot, R. T., Bedi, B., Li, J., & Yeligar, S. M. (2018) · Alcohol · doi:10.1016/j.alcohol.2018.08.006 · Cited by 50
Signaling Pathways and Potential Therapeutic Strategies in Cardiac Fibrosis
Foucault‐Bertaud, A., Joshkon, A., Heim, X., Bachelier, R., Bardin, N., Leroyer, A. S., & Blot‐Chabaud, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021756 · Cited by 54
Translation-Linked mRNA Destabilization Accompanying Serum-Induced Nox4 Expression in Human Endothelial Cells
Peshavariya, H., Jiang, F., Taylor, C. J., Selemidis, S., Chang, C. W. T., & Dusting, G. J. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2579 · Cited by 50
A mitochondrial thioredoxin-sensitive mechanism regulates TGF-β-mediated gene expression associated with epithelial–mesenchymal transition
Ishikawa, F., Kaneko, E., Sugimoto, T., Ishijima, T., Wakamatsu, M., Yuasa, A., Sampei, R., Mori, K., Nose, K., & Shibanuma, M. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.12.050 · Cited by 50
Inactivation of sestrin 2 induces TGF-β signaling and partially rescues pulmonary emphysema in a mouse model of COPD
Wempe, F., De-Zolt, S., Koli, K. M., Bangsow, T., Parajuli, N., Dumitrascu, R., Sterner‐Kock, A., Weißmann, N., Keski‐Oja, J., & von Melchner, H. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.004234 · Cited by 50
Transforming growth factor‐β1 elicits Nrf2‐mediated antioxidant responses in aortic smooth muscle cells
Churchman, A. T., Anwar, A. A., Li, F. Y. L., Sato, H., Ishii, T., Mann, G. E., & Siow, R. C. M. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00874.x · Cited by 50
Nox4-Generated Superoxide Drives Angiotensin II-Induced Neural Stem Cell Proliferation
Topchiy, E., Panzhinskiy, E., Griffin, W. S. T., Barger, S. W., Das, M., & Zawada, W. M. (2013) · Developmental Neuroscience · doi:10.1159/000350502 · Cited by 49
How Do Cytokines Trigger Genomic Instability?
Aivaliotis, I. L., Pateras, I. S., Papaioannou, M. D., Glytsou, C., Kontzoglou, K., Johnson, E. O., & Zoumpourlis, V. C. (2012) · BioMed Research International · doi:10.1155/2012/536761 · Cited by 48
Cryptotanshinone Attenuates Cardiac Fibrosis via Downregulation of COX-2, NOX-2, and NOX-4
Ma, Y., Li, H., Yue, Z., Guo, J., Xu, S., Xu, J. Y., Jia, Y., Yu, N., Zhang, B., Liu, S., et al. (2014) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000086 · Cited by 49
TGF-β, IL-6, IL-17 and CTGF direct multiple pathologies of chronic cardiac allograft rejection
Booth, A. J., & Bishop, D. K. (2010) · Immunotherapy · doi:10.2217/imt.10.33 · Cited by 49
Integration of a Superparamagnetic Scaffold and Magnetic Field To Enhance the Wound-Healing Phenotype of Fibroblasts
Hao, S., Zhang, Y., Meng, J., Liu, J., Wen, T., Gu, N., & Xu, H. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b04149 · Cited by 49
Insights on the Pathogenesis of Aneurysm through the Study of Hereditary Aortopathies
Creamer, T. J., Bramel, E. E., & MacFarlane, E. G. (2021) · Genes · doi:10.3390/genes12020183 · Cited by 51
Advance in Iron Metabolism, Oxidative Stress and Cellular Dysfunction in Experimental and Human Kidney Diseases
Xie, T., Yao, L., & Li, X. (2024) · Antioxidants · doi:10.3390/antiox13060659 · Cited by 53
Role of Cellular Senescence and NOX4-Mediated Oxidative Stress in Systemic Sclerosis Pathogenesis
Piera-Velázquez, S., & Jiménez, S. A. (2014) · Current Rheumatology Reports · doi:10.1007/s11926-014-0473-0 · Cited by 49
(Pro)renin promotes fibrosis gene expression in HEK cells through a Nox4-dependent mechanism
Clavreul, N., Sansilvestri, P., Magard, D., Verbeuren, T. J., & Rupin, A. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00119.2010 · Cited by 47
Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Mediates the Differential Responsiveness of Atrial Versus Ventricular Fibroblasts to Transforming Growth Factor-β
Yeh, Y., Kuo, C.-T., Chang, G., Qi, X., Nattel, S., & Chen, W.-J. (2013) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.113.000338 · Cited by 48
Ac-SDKP inhibits transforming growth factor-β1-induced differentiation of human cardiac fibroblasts into myofibroblasts
Peng, H., Carretero, O. A., Peterson, E. L., & Rhaleb, N. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00464.2009 · Cited by 48
Upstream Regulators and Downstream Effectors of NADPH Oxidases as Novel Therapeutic Targets for Diabetic Kidney Disease
Gorin, Y. C., & Wauquier, F. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.0010 · Cited by 49
Drawing on the continuum: a war and post-war political economy of gender-based violence in Bosnia and Herzegovina
Kostovicova, D., Bojicic-Dzelilovic, V., & Henry, M. (2020) · International Feminist Journal of Politics · doi:10.1080/14616742.2019.1692686 · Cited by 48
Plumbagin Ameliorates Diabetic Nephropathy via Interruption of Pathways that Include NOX4 Signalling
Yong, R., Chen, X., Shen, S., Vijayaraj, S. L., Ma, Q., Pollock, C. A., & Saad, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073428 · Cited by 48
Angiotensin II stimulates superoxide production in the thick ascending limb by activating NOX4
Massey, K. J., Hong, N. J., & Garvin, J. L. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00457.2011 · Cited by 46
NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agents
Babalola, O., Mamalis, A., Lev‐Tov, H. A., & Jagdeo, J. R. (2013) · Archives of Dermatological Research · doi:10.1007/s00403-013-1416-8 · Cited by 48
Role of Nicotinamide Adenine Dinucleotide Phosphate–Reduced Oxidase Proteins in Pseudomonas aeruginosa –Induced Lung Inflammation and Permeability
Fu, P., Mohan, V., Syed, M. A., Tiruppathì, C., Sadikot, R. T., & Natarajan, V. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0242oc · Cited by 47
Role of redoximiRs in fibrogenesis
Fierro‐Fernández, M., Miguel, V., & Lamas, S. (2015) · Redox Biology · doi:10.1016/j.redox.2015.11.006 · Cited by 48
Emerging role of hydrogen sulfide-microRNA crosstalk in cardiovascular diseases
Hackfort, B. T., & Mishra, P. K. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00660.2015 · Cited by 47
NADPH oxidase 4 deficiency leads to impaired wound repair and reduced dityrosine-crosslinking, but does not affect myofibroblast formation
André‐Lévigne, D., Modarressi, A., Krause, K., & Pittet-Cuenod, B. M. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.194 · Cited by 48
Effects of particulate matter from straw burning on lung fibrosis in mice
Hu, Y., Wang, L.-S., Li, Y., Li, Q., Li, C., Chen, J., Weng, D., & Li, H. (2017) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2017.10.001 · Cited by 47
Up-regulation of Nrf2/HO-1 and inhibition of TGF-β1/Smad2/3 signaling axis by daphnetin alleviates transverse aortic constriction-induced cardiac remodeling in mice
Syed, A. M., Kundu, S., Ram, C., Kulhari, U., Kumar, A., Mugale, M. N., Mohapatra, P., Murty, U. S., & Sahu, B. D. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.04.019 · Cited by 48
The NADPH oxidases NOX4 and DUOX2 regulate cell cycle entry via a p53-dependent pathway
Salmeen, A. E., Park, B. O., & Meyer, T. (2010) · Oncogene · doi:10.1038/onc.2010.200 · Cited by 50
The dynamic interplay between cardiac mitochondrial health and myocardial structural remodeling in metabolic heart disease, aging, and heart failure
Werbner, B., Tavakoli‐Rouzbehani, O. M., Fatahian, A. N., & Boudina, S. (2023) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.42 · Cited by 44
Myofibroblast Differentiation: Main Features, Biomedical Relevance, and the Role of Reactive Oxygen Species
Siani, A., & Tirelli, N. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5724 · Cited by 45
Nox-4 and progressive kidney disease
Thallas‐Bonke, V., Jandeleit-Dahm, K. A. M., & Cooper, M. E. (2014) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000082 · Cited by 46
Neferine inhibits proliferation and collagen synthesis induced by high glucose in cardiac fibroblasts and reduces cardiac fibrosis in diabetic mice
Liu, X., Song, X., Lu, J., Chen, X., Liang, E., Liu, X., Zhang, M., Zhang, Y., Du, Z., & Zhao, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.11225 · Cited by 46
NADPH oxidase, oxidative stress and fibrosis in systemic sclerosis
Svegliati, S., Spadoni, T., Moroncini, G., & Gabrielli, A. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.04.554 · Cited by 47
NADPH Oxidase 4 Regulates Inflammation in Ischemic Heart Failure: Role of Soluble Epoxide Hydrolase
Stevenson, M., Canugovi, C., Vendrov, A. E., Hayami, T., Bowles, D. E., Krause, K., Madamanchi, N. R., & Runge, M. S. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7548 · Cited by 46
Mesenchymal Phenotype Predisposes Lung Cancer Cells to Impaired Proliferation and Redox Stress in Response to Glutaminase Inhibition
Ulanet, D., Couto, K., Jha, A., Choe, S. E., Wang, Y., Woo, H.-K., Steadman, M., DeLaBarre, B., Größ, S., Driggers, E. M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115144 · Cited by 49
The axis of local cardiac endogenous Klotho-TGF-β1-Wnt signaling mediates cardiac fibrosis in human
Liu, Q., Zhu, L.-J., Waaga-Gasser, A. M., Ding, Y., Cao, M., Jadhav, S., Kirollos, S., Shekar, P., Padera, R. F., Chang, Y.-C., et al. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.09.004 · Cited by 47
A subset of N-substituted phenothiazines inhibits NADPH oxidases
Seredenina, T., Chiriano, G., Filippova, A., Nayernia, Z., Mahiout, Z., Fioraso-Cartier, L., Plastre, O., Scapozza, L., Krause, K.-H., & Jaquet, V. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.023 · Cited by 45
Molecular Approaches and Echocardiographic Deformation Imaging in Detecting Myocardial Fibrosis
Sonaglioni, A., Nicolosi, G. L., Rigamonti, E., Lombardo, M., & Sala, L. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810944 · Cited by 45
Combined effects of interleukin-1α and transforming growth factor-β1 on modulation of human cardiac fibroblast function
van Nieuwenhoven, F. A., Hemmings, K. E., Porter, K. E., & Turner, N. A. (2013) · Matrix Biology · doi:10.1016/j.matbio.2013.03.008 · Cited by 45
Mitochondrial Dysfunction as Substrate for Arrhythmogenic Cardiomyopathy: A Search for New Disease Mechanisms
van Opbergen, C. J. M., den Braven, L., Delmar, M., & van Veen, T. A. B. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01496 · Cited by 47
TGF-β activates NLRP3 inflammasome by an autocrine production of TGF-β in LX-2 human hepatic stellate cells
Kang, H., Seo, E., Oh, Y. S., & Jun, H. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04369-5 · Cited by 49
Aldosterone Induces Tissue Inhibitor of Metalloproteinases-1 Expression and Further Contributes to Collagen Accumulation
Hung, C., Chou, C., Liao, C., Lin, Y.-T., Wu, X.-M., Chang, Y., Chen, Y.-H., Wu, V., Su, M., Ho, Y., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06768 · Cited by 44
Notch Signaling May Negatively Regulate Neonatal Rat Cardiac Fibroblast-Myofibroblast Transformation
Fan, Y., Dong, H., PAN, Q., Cao, Y., LI, H., & WANG, H.-C. (2011) · Physiological Research · doi:10.33549/physiolres.932149 · Cited by 44
MnTE-2-PyP Treatment, or NOX4 Inhibition, Protects against Radiation-Induced Damage in Mouse Primary Prostate Fibroblasts by Inhibiting the TGF-Beta 1 Signaling Pathway
Chatterjee, A., Kosmacek, E. A., & Oberley‐Deegan, R. E. (2017) · Radiation Research · doi:10.1667/rr14623.1 · Cited by 44
MicroRNA-98 inhibits TGF-β1-induced differentiation and collagen production of cardiac fibroblasts by targeting TGFBR1
Cheng, R., Dang, R.-Y., Zhou, Y., Ding, M., & Hua, H. (2017) · Human Cell · doi:10.1007/s13577-017-0163-0 · Cited by 44
Circadian Clock Control of Nox4 and Reactive Oxygen Species in the Vasculature
Anea, C. B., Zhang, M., Chen, F., Ali, M. I., Hart, C. M., Stepp, D. W., Kovalenkov, Y. O., Merloiu, A. M., Pati, P., Fulton, D. J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078626 · Cited by 43
Cardiac Physiology of Aging: Extracellular Considerations
Horn, M. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140063 · Cited by 46
Salivary antioxidants in patients with systemic sclerosis
Zalewska, A., Knaś, M., Gińdzieńska‐Sieśkiewicz, E., Waszkiewicz, N., Klimiuk, A., Litwin, K., Sierakowski, S., & Waszkiel, D. (2013) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12084 · Cited by 43
Mesenchymal stem cell–derived microvesicles alleviate pulmonary arterial hypertension by regulating renin-angiotensin system
Liu, Z., Liu, J., Xiao, M., Wang, J., Yao, F., Zeng, W., Yu, L., Guan, Y., Wei, W., Peng, Z., et al. (2018) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2018.02.006 · Cited by 41
Transforming growth factor–β1 mediated CHST11 and CHSY1 mRNA expression is ROS dependent in vascular smooth muscle cells
Mohamed, R., Dayati, P., Niayesh‐Mehr, R., Kamato, D., Seif, F., Babaahmadi‐Rezaei, H., & Little, P. J. (2018) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-018-0495-x · Cited by 43
Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma
Ruan, Q., Wang, H., Burke, L. J., Bridle, K. R., Li, X., Zhao, C., Crawford, D. H., Roberts, M. S., & Liang, X. (2020) · International Journal of Cancer · doi:10.1002/ijc.32899 · Cited by 43
Oxidation, Inflammation, and Aortic Valve Calcification
Towler, D. A. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.044 · Cited by 43
An antioxidant nanozyme for targeted cardiac fibrosis therapy post myocardial infarction
Gu, Z., Liu, X., Qi, Z., Zhou, F., Jiang, Y., Huang, Y.-T., Wang, Y., Wu, L., & Yang, Y. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-03047-6 · Cited by 42
Differential growth factor regulation of N-cadherin expression and motility in normal and malignant oral epithelium
Diamond, M. E., Sun, L., Ottaviano, A. J., Joseph, M. J., & Munshi, H. G. (2008) · Journal of Cell Science · doi:10.1242/jcs.021782 · Cited by 42
NADPH oxidase 5 promotes proliferation and fibrosis in human hepatic stellate cells
Andueza, A., Garde, N., García-Garzón, A., Ansorena, E., López-Zabalza, M. J., Iraburu, M. J., Zalba, G., & Martínez-Irujo, J. J. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.07.013 · Cited by 42
p21waf1/cip1/sdi1as a Central Regulator of Inducible Smooth Muscle Actin Expression and Differentiation of Cardiac Fibroblasts to Myofibroblasts
Roy, S., Khanna, S., Rink, T., Radtke, J. R., Williams, W. T., Biswas, S., Schnitt, R., Strauch, A. R., & Sen, C. K. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-03-0270 · Cited by 42
Oxidative stress and atrial fibrillation
Pfenniger, A., Yoo, S., & Arora, R. (2024) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2024.09.011 · Cited by 49
Nox4-dependent H2O2 production contributes to chronic glutamate toxicity in primary cortical neurons
Ha, J. S., Lee, J. E., Lee, J.-R., Lee, C.-S., Maeng, J.-S., Bae, Y. S., Kwon, K., & Park, S. S. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.03.021 · Cited by 43
A novel Gallic acid derivative attenuates BLM-induced pulmonary fibrosis in mice
Rong, Y., Cao, B., Liu, B., Li, W., Chen, Y., Chen, H., Liu, Y., & Liu, T. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.08.024 · Cited by 41
The ageing lung under stress
Korfei, M., MacKenzie, B., & Meiners, S. (2020) · European Respiratory Review · doi:10.1183/16000617.0126-2020 · Cited by 42
Wound Healing After Alkali Burn Injury of the Cornea Involves Nox4-Type NADPH Oxidase
Hakami, N., Dusting, G. J., Chan, E. C., Shah, M. H., & Peshavariya, H. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.12.20 · Cited by 41
Co-delivery of siPTPN13 and siNOX4 via (myo)fibroblast-targeting polymeric micelles for idiopathic pulmonary fibrosis therapy
Hou, J., Ji, Q., Ji, J., Ju, S., Xu, C., Yong, X., Xu, X., Muddassir, M., Chen, X., Xie, J., et al. (2021) · Theranostics · doi:10.7150/thno.54217 · Cited by 45
MicroRNA-495 inhibits the high glucose-induced inflammation, differentiation and extracellular matrix accumulation of cardiac fibroblasts through downregulation of NOD1
Wang, X., Jin, H., Jiang, S., & Xu, Y. (2018) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-018-0089-x · Cited by 40
Quinone compounds regulate the level of ROS production by the NADPH oxidase Nox4
Nguyen, M. V. C., Lardy, B., Rousset, F., Hazane‐Puch, F., Zhang, L., Trocmé, C., Serrander, L., Krause, K., & Morel, F. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.03.023 · Cited by 43
Contribution of different Nox homologues to cardiac remodeling in two-kidney two-clip renovascular hypertensive rats: Effect of valsartan
Wang, P., Tang, F., Li, R., Zhang, H., Chen, S., Liu, P., & Huang, H. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.01.016 · Cited by 40
Mitochondrial-Targeted Antioxidants Attenuate TGF-β2 Signaling in Human Trabecular Meshwork Cells
Rao, V. R., Lautz, J. D., Kaja, S., Foecking, E. M., Lukacs, E., & Stubbs, E. B. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-27542 · Cited by 40
Protective Effects of Eicosapentaenoic Acid on the Glomerular Endothelium via Inhibition of EndMT in Diabetes
Yasuzawa, T., Nakamura, T., Ueshima, S., & Mima, A. (2021) · Journal of Diabetes Research · doi:10.1155/2021/2182225 · Cited by 39
The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity
Tarasenko, N., Kessler‐Icekson, G., Boer, P., Inbal, A., Schlesinger, H., Phillips, D. R., Cutts, S. M., Nudelman, A., & Rephaeli, A. (2010) · Investigational New Drugs · doi:10.1007/s10637-010-9542-z · Cited by 39
Cardiac dysfunction and pathology in the dystrophin and utrophin-deficient mouse during development of dilated cardiomyopathy
Chun, J. L., O’Brien, R. T., & Berry, S. E. (2012) · Neuromuscular Disorders · doi:10.1016/j.nmd.2011.07.003 · Cited by 39
NADPH oxidase: recent evidence for its role in erectile dysfunction
Jin, L., & Burnett, A. L. “. (2008) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2008.00371.x · Cited by 37
Homocysteine‐induced myofibroblast differentiation in mouse aortic endothelial cells
Sen, U., Moshal, K. S., Tyagi, N., Kartha, G., & Tyagi, S. C. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20752 · Cited by 39
Upregulation of Nox4 induces a pro-survival Nrf2 response in cancer-associated fibroblasts that promotes tumorigenesis and metastasis, in part via Birc5 induction
Mir, S. U. R., Ormsbee, B. D., Griess, B., Vengoji, R., Tom, E. C., Kosmacek, E. A., Oberley‐Deegan, R. E., Talmon, G. A., Band, V., & Teoh-Fitzgerald, M. L. T. (2022) · Breast Cancer Research · doi:10.1186/s13058-022-01548-6 · Cited by 44
Selective homocysteine-lowering gene transfer attenuates pressure overload-induced cardiomyopathy via reduced oxidative stress
Muthuramu, I., Singh, N., Amin, R., Nefyodova, E., Debasse, M., Horenbeeck, I. V., Jacobs, F., & Geest, B. D. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1281-3 · Cited by 38
Decursin attenuates hepatic fibrogenesis through interrupting TGF-beta-mediated NAD(P)H oxidase activation and Smad signaling in vivo and in vitro
Choi, Y. J., Kim, D. H., Kim, S. J., Kim, J., Jeong, S.-I., Chung, C. H., Yu, K.-Y., & Kim, S. Y. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.05.012 · Cited by 38
Adventitial Fibroblast Nox4 Expression and ROS Signaling in Pulmonary Arterial Hypertension
Barman, S. A., & Fulton, D. J. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-63245-2_1 · Cited by 39
Interaction between p22phox and Nox4 in the endoplasmic reticulum suggests a unique mechanism of NADPH oxidase complex formation
Zana, M., Péterfi, Z., Kovács, H. A., Tóth, Z., Enyedi, B., Morel, F., Paclet, M., Donkó, Á., Morand, S. C., Leto, T. L., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.12.031 · Cited by 39
Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure
McCarty, M. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073321 · Cited by 41
Curcumin suppresses transforming growth factor-β1-induced cardiac fibroblast differentiation via inhibition of Smad-2 and p38 MAPK signaling pathways
Liu, H., Liu, A., Chunli, S., & Li, B. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.2969 · Cited by 38
TGF-β as a therapeutic target in the infarcted and failing heart: cellular mechanisms, challenges, and opportunities
Frangogiannis, N. G. (2024) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2024.2316735 · Cited by 39
Pro-oxidant effect of transforming growth factor- 1 mediates contractile dysfunction in rat ventricular myocytes
Li, S., Li, X., Zheng, H., Xie, B., Bidasee, K. R., & Rozanski, G. J. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm022 · Cited by 37

Authors: Cucoranu, I., Clempus, R., Dikalova, A., Phelan, P. J., Ariyan, S., Dikalov, S., & Sorescu, D.
Affiliations: Emory University (US)
ORCID: Dikalova, Anna
Phelan, Patrick J.
Dikalov, Sergey
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-10-28
Volume: 97
Issue: 9
Pages: 900-907
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/01.res.0000187457.24338.3d
OpenAlex: W2162514162
Cited by: 786
References: 41
Citations by year: 2026: 24 · 2025: 17 · 2024: 19 · 2023: 39 · 2022: 47 · 2021: 35 · 2020: 39 · 2019: 33 · 2018: 42 · 2017: 47 · 2016: 44 · 2015: 52 · 2014: 51 · 2013: 54 · 2012: 52
FWCI: 18.50
Type: journal article
Language: en
Open access: closed
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Institutes of Health
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: NOX4, cardiac fibroblasts, myofibroblast differentiation, TGF-β1, myocardial fibrosis, smooth muscle actin, reactive oxygen species, superoxide, Smad2/3 phosphorylation, heart failure, cardiac hypertrophy, extracellular matrix
MeSH terms: NADPH Oxidase 4, Actins, Cell Differentiation, Cells, Cultured, Fibroblasts, Fibrosis, Humans, Myocardium, RNA, Messenger, Superoxides, Transforming Growth Factor beta, Reactive Oxygen Species, Immediate-Early Proteins, NADPH Oxidases, Intercellular Signaling Peptides and Proteins, Smad2 Protein, Smad3 Protein, Transforming Growth Factor beta1, Connective Tissue Growth Factor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

NAD(P)H Oxidase 4 Mediates Transforming Growth Factor-β1–Induced Differentiation of Cardiac Fibroblasts Into Myofibroblasts

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks