Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66 shc Gene

Bone marrow cells regenerate infarcted myocardium

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Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration

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Mobilized bone marrow cells repair the infarcted heart, improving function and survival

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The p66shc adaptor protein controls oxidative stress response and life span in mammals

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Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis

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Regulation of Telomerase by Telomeric Proteins

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Myocardial Cell Death in Human Diabetes

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Cellular Senescence in Cardiovascular Diseases: From Pathogenesis to Therapeutic Challenges

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Type 1 diabetes mellitus abrogates compensatory augmentation of myocardial neuregulin-1β/ErbB in response to myocardial infarction resulting in worsening heart failure

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The p66ShcA adaptor protein regulates healing after myocardial infarction

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Role of Cellular Senescence in Lifestyle-Related Disease

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Cardiac Injury Following Chemo/Radiation Therapy: An Updated Review on Mechanisms and Therapeutic Approaches

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The p66Shc protein controls redox signaling and oxidation-dependent DNA damage in human liver cells

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Advanced nutritional and stem cells approaches to prevent equine metabolic syndrome

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CRIF1 Deficiency Induces p66shc-Mediated Oxidative Stress and Endothelial Activation

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The Potential of Stem Cells in the Treatment of Cardiovascular Diseases

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Trichostatin a modulates intracellular reactive oxygen species through SOD2 and FOXO1 in human bone marrow‐mesenchymal stem cells

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The role of radix hedysari polysaccharide on the human umbilical vein endothelial cells (HUVECs) induced by high glucose

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Klotho deficiency aggravates diabetes-induced podocyte injury due to DNA damage caused by mitochondrial dysfunction

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p66Shc gene expression in peripheral blood mononuclear cells and progression of diabetic complications

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Insulin-like growth factor-1 short-period therapy improves cardiomyopathy stimulating cardiac progenitor cells survival in obese mice

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Targeting senescence to prevent diabetic kidney disease: Exploring molecular mechanisms and potential therapeutic targets for disease management

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Hyperhomocysteinemia inhibited cardiac stem cell homing into the peri-infarcted area post myocardial infarction in rats

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Prolonged swimming promotes cellular oxidative stress and p66Shc phosphorylation, but does not induce oxidative stress in mitochondria in the rat heart

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Mitochondrial Tolerance to Drugs and Toxic Agents in Ageing and Disease

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Investigating The Alterations of Oxidative Stress Status, Antioxidant Defense Mechanisms, MAP Kinase and Mitochondrial Apoptotic Pathway in Adipose-Derived Mesenchymal Stem Cells from STZ Diabetic Rats.

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Cardiovascular Disease and Aging

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Reactive Oxygen/Nitrogen Species and the Myocardial Cell Homeostasis: An Ambiguous Relationship

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Molecular mechanisms of cardiomyocyte regeneration and therapeutic outlook

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Mitochondria as therapeutic targets for Natural Products in the treatment of Cardiovascular Diseases

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Human Umbilical Cord Blood Mononuclear Cells Decrease Fibrosis and Increase Cardiac Function in Cardiomyopathy

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REMOVED: Concussive head injury exacerbates neuropathology of sleep deprivation: Superior neuroprotection by co-administration of TiO2-nanowired cerebrolysin, alpha-melanocyte-stimulating hormone, and mesenchymal stem cells

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Chronic Heart Failure Is Associated With Transforming Growth Factor Beta‐Dependent Yield and Functional Decline in Atrial Explant‐Derived c‐Kit+ Cells

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The Role of Mitochondria in Metabolic Syndrome–Associated Cardiomyopathy

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Generating Double Knockout Mice to Model Genetic Intervention for Diabetic Cardiomyopathy in Humans

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Interplay between gut microbiota and p66Shc affects obesity‐associated insulin resistance

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Reactive Oxygen Species in the Induction of Toxicity

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Concise Review: Challenges in Regenerating the Diabetic Heart: A Comprehensive Review

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Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells

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Characterization of Superoxide Dismutases in Cardiac Progenitor Cells Demonstrates a Critical Role for Manganese Superoxide Dismutase

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Regenerative toxicology: the role of stem cells in the development of chronic toxicities

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Collection and immunoselection of CD34+ cells: the impact of age, sex, and diabetes in patients with chronic heart failure

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High Glucose Causes Human Cardiac Progenitor Cell Dysfunction by Promoting Mitochondrial Fission: Role of a GLUT1 Blocker

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Effects of the calcium sensitizer OR‐1896, a metabolite of levosimendan, on post‐infarct heart failure and cardiac remodelling in diabetic Goto–Kakizaki rats

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Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney

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Role of p66shc in skeletal muscle function

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The influence of disease and age on human cardiac stem cells

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Transplantation of Epigenetically Modified Adult Cardiac c-Kit+ Cells Retards Remodeling and Improves Cardiac Function in Ischemic Heart Failure Model

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Interaction between mitochondrial oxidative stress and myocardial fibrosis in the context of diabetes

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Postmyocardial Infarct Remodeling and Heart Failure: Potential Contributions from Pro- and Antiaging Factors

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How Resident Stem Cells Communicate with Cardiac Cells in Beating Heart?

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Strategies for future histocompatible stem cell therapy

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p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo

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Lack of Contribution of p66shc to Pressure Overload-Induced Right Heart Hypertrophy

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Opportunities and Challenges in Stem Cell Aging

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Diabetes Mellitus: An Opportunity for Therapy with Stem Cells?

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Cardiac Tissue Engineering: A Clinical Perspective

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Heart Failure with Preserved Ejection Fraction and Diabetes Mellitus

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Pump to Survive

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Deletion of p66 S hc in mice increases the frequency of size‐change mutations in the lac Z transgene

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Aging phenotype(s) in kidneys of diabetic mice are p66ShcA dependent

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Vascular Progenitor Cells in Diabetes Mellitus

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Paradoxical effect of fat diet in matrix metalloproteinases induced mitochondrial dysfunction in diabetic cardiomyopathy

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Biased DNA Segregation During Stem Cell Division

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Caloric restriction does not alter effects of aging in cardiac side population cells

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Diabetic cardiomyopathy—What do we know about it?

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The Role of Mitochondrial Reactive Oxygen Species Formation for Age-Induced Vascular Dysfunction

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Recombinant adenovirus of human p66Shc inhibits MCF-7 cell proliferation

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A Novel Class of Human Cardiac Stem Cells

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Cardiac Aging

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Five-factor theory of aging and death due to aging

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Maternal diabetes and high glucose in vitro trigger Sca1 + cardiac progenitor cell apoptosis through FoxO3a

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Stem Cells as a Tool for Breast Imaging

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Cardiac Aging

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Proteomics-derived organ-specific aging clusters predict macrovascular and microvascular complications in diabetes

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Polyphenols of Salvia miltiorrhiza in Aging-Associated Cardiovascular Diseases and Cancer

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Restrictive Cardiomyopathy

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Cardiac-specific overexpression of insulin-like growth factor II receptor-α interferes with the regulation of calcium homeostasis in the heart under hyperglycemic conditions

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Cardiac Regeneration and Aging

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Overexpression of Gsα compensates for myocyte loss in diabetic cardiomyopathyPresented in part at the American Heart Association meeting, New Orleans, Louisiana, November 2004.

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Number and function impairment of resident C-Kit+ cardiac stem cells in mice with renal dysfunction caused by 5/6 nephrectomy

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Molecular Targets and Novel Therapeutics to Target Oxidative Stress in Cardiovascular Diseases

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Aging and the Cardiovascular System

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Activation of the Local Regenerative System of the Heart

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Mitochondrial Dysfunction in Cell Injury and Cardiotoxicity

Lisa, F. D., Semenzato, M., Carpi, A., Menazza, S., Kaludercic, N., Menabò, R., & Canton, M. (2010) · Wiley eBooks · doi:10.1002/9780470660379.ch1 · Cited by 3

Traumatic-Brain Injury and Cardiovascular Diseases: Oxidative Stress at the Crossroad Linking TBI-Induced Autonomic Dysfunction to Cardiovascular Impairment

Ibeh, S., Babale, I., Morah, A. C., Khachab, M. Y., Eid, A. H., & Kobeissy, F. H. (2024) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-031-62131-4_7 · Cited by 3

Attenuating senescence and dead cells accumulation as heart failure therapy: Break the communication networks

Jackson, A. O., Rahman, G. A., & Long, S. (2021) · International Journal of Cardiology · doi:10.1016/j.ijcard.2021.03.061 · Cited by 3

Cardiac Stem Cells: Tales, Mysteries and Promises in Heart Generation and Regeneration

Pesce, M., Pompilio, G., Gambini, E., & Capogrossi, M. C. (2010) · Springer eBooks · doi:10.1007/978-90-481-9075-1_12 · Cited by 2

Role of endothelial progenitor cells in diabetes mellitus

Avogaro, A., & Fadini, G. P. (2009) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.09.49 · Cited by 2

Cardiomyocyte changes in the metabolic syndrome and implications for endogeneous protective strategies

Oosterlinck, W., & Herijgers, P. (2014) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2014.893825 · Cited by 2

The Stem Cell Hypothesis of Aging

Meiliana, A., & Wijaya, A. (2010) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v2i1.108 · Cited by 2

Nitroso-Redox Crosstalk in Diabetic Cardiomyopathy

González, D. R., Treuer, A. V., & Novoa, U. (2016) · InTech eBooks · doi:10.5772/63668 · Cited by 1

Invited commentary

Tang, Y., & Phillips, M. I. (2007) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.11.054 · Cited by 2

Extracellular Vesicles and Cardiac Aging

Seara, F. D. A. C., Maciel, L., Kasai-Brunswick, T. H., Nascimento, J. H. M., & de Carvalho, A. C. C. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-99-1443-2_3 · Cited by 2

Restrictive Cardiomyopathy

Kirkels, J. H., & de Jonge, N. (2016) · Springer eBooks · doi:10.1007/978-3-319-44203-7_8 · Cited by 2

Stem Cell Therapy in Diabetes

Avogaro, A., & Fadini, G. P. (2016) · doi:10.1002/9781118924853.ch68 · Cited by 2

Investigating the research trajectory and future trends in type 2 diabetes mellitus and aging: a bibliometric analysis from 2009 to 2025 based on big data

Gong, T., Jiang, W., Han, Y., Liu, Y., Zhuo, W., Li, S., Hu, Z., Zeng, Z., Yue, R., & Yang, M. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1779773 · Cited by 1

Pharmacologic Inhibition of Cardiac Stem Cell Senescence

Cesselli, D., Caragnano, A., Bergamin, N., Zanon, V., Finato, N., Livi, U., Alberto, C., & Paolo, A. (2012) · InTech eBooks · doi:10.5772/33732 · Cited by 1

Mechanisms of Cardiovascular Aging

Paneni, F., Costantino, S., Cosentino, F., & Lüscher, T. F. (2013) · Current Translational Geriatrics and Experimental Gerontology Reports · doi:10.1007/s13670-013-0061-6 · Cited by 1

Cardiomyopathy in diabetics: a review of current opinion on the underlying pathological mechanisms

Ashrafi, R., & Davis, G. K. (2011) · Avances en Diabetología · doi:10.1016/j.avdiab.2011.08.002 · Cited by 1

Progenitor Cells from the Adult Heart

Ellison, G. M., & Lewis, F. (2017) · Cardiac and vascular biology · doi:10.1007/978-3-319-56106-6_2 · Cited by 1

Potential New Drug Targets Modulating the Environmentally-Induced Oxidative Stress in the Cardiovascular System

Đurašević, S., Zdravkovic, M. D., Nikolić, V., & Todorović, Z. (2024) · Advances in biochemistry in health and disease · doi:10.1007/978-3-031-62806-1_21 · Cited by 1

The role of doxorubicin in the formation of cardiotoxicity is a consensus statement. Part II. Cardiotoxicity of doxorubicin unrelated to myocytes and cardioprotection strategy (review)

Andreev, D. A., Balakin, E. I., Самойлов, А. С., & Pustovoit, V. I. (2024) · Drug development & registration · doi:10.33380/2305-2066-2024-13-3-1730 · Cited by 1

Signaling in the Aging Heart

Marı́n-Garcı́a, J. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9461-5_11 · Cited by 1

Isolation, characterization and ex vivo amplification of heart-derived c-kit progenitor cells for cellular therapy

Gambini, E. (2009) · BOA (University of Milano-Bicocca) · Cited by 1

Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc

Rota, M., Lecapitaine, N., Hosoda, T., Boni, R., Angelis, A. D., Padin-iruegas, M. E., Esposito, G., Vitale, S., Urbanek, K., Casarsa, C., et al. (2006)

Diabetic Cardiomyopathy A “Cardiac Stem Cell Disease ” Involving p66Shc, an Attractive Novel Molecular Target for Heart Failure Therapy

Messina, E., & Giacomello, R. (2016)

Potential etiology of diabetic cardiomyopathy

Bai, Y., Zhou, J., Sun, A., Qian, J., Zou, Y., & Ge, J. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht309.p3255

p66Shc protein, oxidative stress, and cardiovascular complications of diabetes: the missing link

Francia, P., Cosentino, F., Schiavoni, M., Huang, Y., Perna, E., Camici, G. G., Lüscher, T. F., & Volpe, M. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0499-3 · Cited by 54

Deletion of the p66shc gene protects from diabetic cardiomyopathy by activation of cardiac stem cells that leads to increased proliferation of myocytes

Casarsa, C., Padin Iruegas, M. E., Rota, M., Whang, B., Urbanek, K., Mendez Ferrer, S., Pelice, P. G., Nadal‐Ginard, B., Anversa, P., Kajstura, J., et al. (2004) · Institutional Research Information System University of Turin (University of Turin)