Pelicci, Pier Giuseppe

Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype

Falini, B., Mecucci, C., Tiacci, E., Alcalay, M., Rosati, R., Pasqualucci, L., La Starza, R., Diverio, D., Colombo, E., Santucci, A., et al. (2005) · New England Journal of Medicine

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 1,892

The p66shc adaptor protein controls oxidative stress response and life span in mammals

Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature

Genetics, Aging, and Longevity in Model OrganismsCell death mechanisms and regulation

Cited by 1,712

The tripartite motif family identifies cell compartments

Reymond, A., Meroni, G., Fantozzi, A., Merla, G., Cairo, S., Luzi, L., Riganelli, D., Zanaria, E., Messali, S., Cainarca, S., et al. (2001) · The EMBO Journal

Genomics and Chromatin DynamicsRNA Research and Splicing

Cited by 1,366

Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis

Giorgio, M., Migliaccio, E., Orsini, F., Paolucci, D., Moroni, M., Contursi, C., Pelliccia, G., Luzi, L., Minucci, S., Marcaccio, M., et al. (2005) · Cell

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 1,176

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis

Trinei, M., Giorgio, M., Cicalese, A., Barozzi, S., Ventura, A., Migliaccio, E., Milia, E., Padura, I. M., Raker, V. A., Maccarana, M., et al. (2002) · Oncogene

Cancer-related Molecular PathwaysRedox biology and oxidative stress

Cited by 436

Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66 shc Gene

Rota, M., LeCapitaine, N., Hosoda, T., Boni, A., De Angelis, A., Padin-Iruegas, M. E., Esposito, G., Vitale, S., Urbanek, K., Casarsa, C., et al. (2006) · Circulation Research

Congenital heart defects researchTelomeres, Telomerase, and Senescence

Cited by 330

Binding specificity and in vivo targets of the EH domain, a novel protein–protein interaction module

Salcini, A. E., Confalonieri, S., Doria, M., Santolini, E., Tassi, E., Minenkova, O., Cesareni, G., Pelicci, P. G., & Di Fiore, P. P. (1997) · Genes & Development

Cellular transport and secretionDevelopmental Biology and Gene Regulation

Cited by 315

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

Migliorini, D., Denchi, E. L., Danovi, D., Jochemsen, A., Capillo, M., Gobbi, A., Helin, K., Pelicci, P. G., & Marine, J.-C. (2002) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 313

Amplification of Mdmx (or Mdm4 ) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity

Danovi, D., Meulmeester, E., Pasini, D., Migliorini, D., Capra, M., Frenk, R., de Graaf, P., Francoz, S., Gasparini, P., Gobbi, A., et al. (2004) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 310

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

Elgendy, M., Cirò, M., Hosseini, A., Weiszmann, J., Mazzarella, L., Ferrari, E., Cazzoli, R., Curigliano, G., DeCensi, A., Bonanni, B., et al. (2019) · Cancer Cell

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 299

Deletion of p66 shc Gene Protects Against Age-Related Endothelial Dysfunction

Francia, P., delli Gatti, C., Bachschmid, M., Martin-Padura, I., Savoia, C., Migliaccio, E., Pelicci, P. G., Schiavoni, M., Lüscher, T. F., Volpe, M., et al. (2004) · Circulation

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 298

Expression of adhesion molecules and chemotactic cytokines in cultured human mesothelial cells.

Jonjić, N., Peri, G., Bernasconi, S., Sciacca, F. L., Colotta, F., Pelicci, P., Lanfrancone, L., & Mantovani, A. (1992) · The Journal of experimental medicine

Cell Adhesion Molecules ResearchChemokine receptors and signaling

Cited by 290

Baricitinib restrains the immune dysregulation in patients with severe COVID-19

Bronte, V., Ugel, S., Tinazzi, E., Vella, A., De Sanctis, F., Canè, S., Batani, V., Trovato, R., Fiore, A., Petrova, V., et al. (2020) · Journal of Clinical Investigation

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 281

p66Shc-generated Oxidative Signal Promotes Fat Accumulation

Berniakovich, I., Trinei, M., Stendardo, M., Migliaccio, E., Minucci, S., Bernardi, P., Pelicci, P. G., & Giorgio, M. (2008) · Journal of Biological Chemistry

Adipose Tissue and MetabolismRedox biology and oxidative stress

Cited by 161

Blood orange juice inhibits fat accumulation in mice

Titta, L., Trinei, M., Stendardo, M., Berniakovich, I., Petroni, K., Tonelli, C., Riso, P., Porrini, M., Minucci, S., Pelicci, P. G., et al. (2010) · International Journal of Obesity

Phytochemicals and Antioxidant ActivitiesDiet, Metabolism, and Disease

Cited by 145

DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions.

Insinga, A., Cicalese, A., Faretta, M., Gallo, B., Albano, L., Ronzoni, S., Furia, L., Viale, A., & Pelicci, P. G. (2013) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 140

Maintaining epithelial stemness with p63

Melino, G., Memmi, E. M., Pelicci, P. G., & Bernassola, F. (2015) · Science Signaling

Developmental Biology and Gene RegulationCancer-related Molecular Pathways

Cited by 139

Apoptosis and Aging: Role of p66 Shc Redox Protein

Migliaccio, E., Giorgio, M., & Pelicci, P. G. (2006) · Antioxidants & Redox Signaling

Genetics, Aging, and Longevity in Model OrganismsRedox biology and oxidative stress

Cited by 123

Genome-wide mapping of 8-oxo-7,8-dihydro-2′-deoxyguanosine reveals accumulation of oxidatively-generated damage at DNA replication origins within transcribed long genes of mammalian cells

Amente, S., Di Palo, G., Scala, G., Castrignanò, T., Gorini, F., Cocozza, S., Moresano, A., Pucci, P., Ma, B., Stepanov, I., et al. (2019) · Nucleic Acids Research

DNA Repair MechanismsCarcinogens and Genotoxicity Assessment

Cited by 123

Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice

Berry, A., Capone, F., Giorgio, M., Pelicci, P. G., de Kloet, E. R., Alleva, E., Minghetti, L., & Cirulli, F. (2007) · Experimental Gerontology

Genetics, Aging, and Longevity in Model OrganismsAging and Gerontology Research

Cited by 81

The endless frontier? The recent increase of R&D productivity in pharmaceuticals

Pammolli, F., Righetto, L., Abrignani, S., Pani, L., Pelicci, P. G., & Rabosio, E. (2020) · Journal of Translational Medicine

Pharmaceutical Economics and PolicyFirm Innovation and Growth

Cited by 77

The genomic landscape of 8-oxodG reveals enrichment at specific inherently fragile promoters

Gorini, F., Scala, G., Di Palo, G., Dellino, G. I., Cocozza, S., Pelicci, P. G., Lania, L., Majello, B., & Amente, S. (2020) · Nucleic Acids Research

DNA Repair MechanismsEpigenetics and DNA Methylation

Cited by 67

Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation

Menini, S., Iacobini, C., Ricci, C., Oddi, G., Pesce, C., Pugliese, F., Block, K., Abboud, H. E., Giorgio, M., Migliaccio, E., et al. (2007) · Diabetologia

Advanced Glycation End Products researchChronic Kidney Disease and Diabetes

Cited by 64

p66ShcDeletion Confers Vascular Protection in Advanced Atherosclerosis in Hypercholesterolemic Apolipoprotein E Knockout Mice

Martin-Padura, I., de Nigris, F., Migliaccio, E., Mansueto, G., Minardi, S., Rienzo, M., Lerman, L. O., Stendardo, M., Giorgio, M., De Rosa, G., et al. (2008) · Endothelium

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 52