Cited by 83Traumatic Brain Injury and Neurovascular DisturbancesNeuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury Research

Lesional Accumulation of CD163+ Macrophages/microglia in Rat Traumatic Brain Injury

Zhang, Zhiren, Zhang, Zhi-Yuan, Wu, Yuzhang, Schluesener, Hermann J.·2012·Brain Research

Abstract

A robust neuroinflammation, contributing to the development of secondary injury, is a common histopathological feature of traumatic brain injury (TBI). Characterization of leukocytic subpopulations contributing to the early infiltration of the damaged tissue might aid in further understanding of lesion development. Reactive macrophages/microglia can exert protective or damaging effects in TBI. CD163 is considered a marker of M2 (alternatively activated) macrophages. Therefore we investigated the accumulation of CD163(+) macrophages/microglia in the brain of TBI rats. TBI was induced in rats using an open skull weight-drop contusion model and the accumulation of CD163(+) cells was analyzed by immunohistochemistry. In normal rat brains, CD163 was expressed by meningeal, choroid plexus and perivascular macrophages. Significant parenchymal CD163(+) cell accumulation was observed two days post TBI and continuously increased in the investigated survival time. The accumulated CD163(+) cells were mainly distributed to the lesional areas and exhibited macrophage phenotypes with amoeboid morphologic characteristics but not activated microglial phenotypes with hypertrophic morphology and thick processes. Double-labeling experiments showed that most CD163(+) cells co-expressed heme oxygenase-1 (HO-1). In addition, in vitro incubating of macrophage RAW264.7 cells or primary peritoneal macrophages with hemoglobin- haptoglobin (Hb-Hp) complex suppressed LPS-induced inflammatory macrophages…

Integrity signals

Registry

Crossref · 10.1016/j.brainres.2012.04.038

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • CD163 is expressed exclusively on perivascular macrophages in the brain under normal conditions, as well as peripheral cells of monocyte lineage.

    “CD163 is a hemoglobin-haptoglobulin scavenger receptor that is considered to be expressed exclusively on perivascular macrophages in the brain under normal conditions, as well as peripheral cells of monocyte lineage [38, 56].”
  • Brain parenchymal CD163 positive macrophages correlate with blood-brain barrier damage in other white matter disorders.

    “Brain parenchymal CD163 positive macrophages correlate with blood-brain barrier damage in other white matter disorders [5, 45, 56].”

Cites

Flagged first, then by citations

1 of the 50 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Zhang, Z., Zhang, Z.-Y., Wu, Y., & Schluesener, H. J.
Affiliations
  • Army Medical University (CN)
  • University of Tübingen (DE)
Corresponding author
Zhang, Zhiren
Venue
Brain Research
Publisher
Elsevier BV
Published
2012-06
Volume
1461
Pages
102-110
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2150660037
Cited by
83
References
50
Citations by year
2026: 3 · 2025: 6 · 2024: 2 · 2023: 6 · 2022: 10 · 2021: 3 · 2020: 10 · 2019: 7 · 2018: 2 · 2017: 7 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 10 · 2012: 1
FWCI
5.01
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Natural Science Foundation Project (2010BB5025)
  • National Nature Science Foundation of China (81070954)
Topics
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Keywords
traumatic brain injury, CD163, M2 macrophages, microglia, neuroinflammation, heme oxygenase-1, hemoglobin-haptoglobin complex, anti-inflammatory macrophages, secondary injury, contusion injury model, RAW 264.7 macrophages, peritoneal macrophages
MeSH terms
CD163 Antigen, Animals, Brain Injuries, Cell Line, Macrophages, Male, Rats, Inbred Lew, Receptors, Cell Surface, Antigens, Differentiation, Myelomonocytic, Antigens, CD, Microglia, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review