The DOI matches its Crossref record; 167 of the 168 references it cites were found in a registry or an index.
Activation of Platelet Function Through G Protein–Coupled Receptors
Abstract
Because of their ability to become rapidly activated at places of vascular injury, platelets are important players in primary hemostasis as well as in arterial thrombosis. In addition, they are also involved in chronic pathological processes including the atherosclerotic remodeling of the vascular system. Although primary adhesion of platelets to the vessel wall is largely independent of G protein–mediated signaling, the subsequent recruitment of additional platelets into a growing platelet thrombus requires mediators such as ADP, thromboxane A 2 , or thrombin, which act through G protein–coupled receptors. Platelet activation via G protein–coupled receptors involves 3 major G protein–mediated signaling pathways that are initiated by the activation of the G proteins G q , G 13 , and G i . This review summarizes recent progress in understanding the mechanisms underlying platelet activation and thrombus extension via G protein–mediated signaling pathways.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Adrenergic receptors are crucially involved in heart disease147 and platelet function148.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [148]
Citations
Cites
Collaboration, A. T. (2002) · BMJ · doi:10.1136/bmj.324.7329.71 · Cited by 6,943
(1996) · The Lancet · doi:10.1016/s0140-6736(96)09457-3 · Cited by 6,503
The phosphoinositide 3-kinase pathway
Cantley, L. C. (2002) · Science · doi:10.1126/science.296.5573.1655 · Cited by 5,621
RHO GTPASES: Biochemistry and Biology
Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009
Fredriksson, R., Lagerström, M. C., Lundin, L.-G., & Schiöth, H. B. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.6.1256 · Cited by 2,941
Dennis, M. S. (1996) · The Lancet · Cited by 2,728
Pierce, K. L., Premont, R. T., & Lefkowitz, R. J. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm908 · Cited by 2,712
Ruggeri, Z. M. (2002) · Nature Medicine · doi:10.1038/nm1102-1227 · Cited by 1,605
Synthesis and Function of 3-Phosphorylated Inositol Lipids
Vanhaesebroeck, B., Leevers, S. J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P. C., Woscholski, R., Parker, P. J., & Waterfield, M. D. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.535 · Cited by 1,535
Platelets in inflammation and atherogenesis
Gawaz, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci27196 · Cited by 1,484
Cited by
Sorted by citations
Platelet Activation and Atherothrombosis
Davì, G., & Patrono, C. (2007) · New England Journal of Medicine · doi:10.1056/nejmra071014 · Cited by 2,135
New Fundamentals in Hemostasis
Versteeg, H. H., Heemskerk, J. W. M., Levi, M. M., & Reitsma, P. H. (2013) · Physiological Reviews · doi:10.1152/physrev.00016.2011 · Cited by 1,131
Gut microbiota and cardiovascular disease.
Witkowski, M., Weeks, T. L., & Hazen, S. L. (2020) · Circulation Research · doi:10.1161/circresaha.120.316242 · Cited by 1,051
Signaling During Platelet Adhesion and Activation
Li, Z., Delaney, M. K., O’Brien, K., & Du, X. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.207522 · Cited by 914
The platelet contribution to cancer progression
Bambace, N. M., & Holmes, C. E. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.04131.x · Cited by 706
Metadata
- Authors
- Offermanns, S.
- Affiliations
- Heidelberg University (DE)
- Corresponding author
- Offermanns, Stefan
- ORCID
- Offermanns, Stefan
- Venue
- Circulation Research
- Published
- 2006-12-08
- Volume
- 99
- Issue
- 12
- Pages
- 1293-1304
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2161488081
- Cited by
- 725
- References
- 168
- Citations by year
- 2026: 32 · 2025: 33 · 2024: 37 · 2023: 30 · 2022: 52 · 2021: 42 · 2020: 37 · 2019: 38 · 2018: 23 · 2017: 53 · 2016: 34 · 2015: 45 · 2014: 33 · 2013: 46 · 2012: 29
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Circulation Research
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- platelet activation, G protein-coupled receptors, G protein signaling, Gq, G13, Gi, thrombus extension, primary hemostasis, arterial thrombosis, atherosclerosis, thromboxane A2, thrombin, ADP, platelet adhesion
- MeSH terms
- Animals, Blood Platelets, Humans, Thrombosis, Platelet Activation, Receptors, G-Protein-Coupled
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
