Offermanns, Stefan

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis

Singh, N., Gurav, A., Sivaprakasam, S., Brady, E., Padia, R., Shi, H., Thangaraju, M., Prasad, P. D., Manicassamy, S., Munn, D. H., et al. (2014) · Immunity

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 2,368

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition.

Chang, P. V., Hao, L., Offermanns, S., & Medzhitov, R. (2014) · Proceedings of the National Academy of Sciences

Gut microbiota and healthInflammatory Bowel Disease

Cited by 2,175

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

Macia, L., Tan, J., Vieira, A. T., Leach, K., Stanley, D., Luong, S., Maruya, M., Ian McKenzie, C., Hijikata, A., Wong, C., et al. (2015) · Nature Communications

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 1,439

Activation of Platelet Function Through G Protein–Coupled Receptors

Offermanns, S. (2006) · Circulation Research

Platelet Disorders and TreatmentsBlood Coagulation and Thrombosis Mechanisms

Cited by 725

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

Wang, S., Chennupati, R., Kaur, H., Iring, A., Wettschureck, N., & Offermanns, S. (2016) · Journal of Clinical Investigation

Adenosine and Purinergic SignalingNitric Oxide and Endothelin Effects

Cited by 616

Regeneration of fat cells from myofibroblasts during wound healing

Plikus, M. V., Guerrero-Juarez, C. F., Ito, M., Li, Y. R., Dedhia, P. H., Zheng, Y., Shao, M., Gay, D. L., Ramos, R., Hsi, T.-C., et al. (2017) · Science

Wound Healing and TreatmentsHair Growth and Disorders

Cited by 584

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

Morland, C., Andersson, K. A., Haugen, Ø. P., Hadzic, A., Kleppa, L., Gille, A., Rinholm, J. E., Palibrk, V., Diget, E. H., Kennedy, L. H., et al. (2017) · Nature Communications

Angiogenesis and VEGF in CancerBarrier Structure and Function Studies

Cited by 559

The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells

Kespohl, M., Vachharajani, N., Luu, M., Harb, H., Pautz, S., Wolff, S., Sillner, N., Walker, A., Schmitt-Kopplin, P., Boettger, T., et al. (2017) · Frontiers in Immunology

Gut microbiota and healthT-cell and B-cell Immunology

Cited by 294

Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases

Singh, N., Thangaraju, M., Prasad, P. D., Martin, P. M., Lambert, N. A., Boettger, T., Offermanns, S., & Ganapathy, V. (2010) · Journal of Biological Chemistry

Gut microbiota and healthImmunotherapy and Immune Responses

Cited by 293

The human thyrotropin receptor activates G-proteins gs and Gq/11

Allgeier, A., Offermanns, S., Van Sande, J., Spicher, K., Schultz, G., & Dumont, J. E. (1994) · Journal of Biological Chemistry

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 192

Conserved MIP receptor–ligand pair regulates Platynereis larval settlement

Conzelmann, M., Williams, E. A., Tunaru, S., Randel, N., Shahidi, R., Asadulina, A., Berger, J., Offermanns, S., & Jékely, G. (2013) · Proceedings of the National Academy of Sciences

Neuropeptides and Animal PhysiologyMarine Invertebrate Physiology and Ecology

Cited by 155

Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development

Kero, J., Ahmed, K., Wettschureck, N., Tunaru, S., Wintermantel, T., Greiner, E., Schütz, G., & Offermanns, S. (2007) · Journal of Clinical Investigation

Thyroid Disorders and TreatmentsReceptor Mechanisms and Signaling

Cited by 124

Plexin-B2, But Not Plexin-B1, Critically Modulates Neuronal Migration and Patterning of the Developing Nervous System In Vivo

Deng, S., Hirschberg, A., Worzfeld, T., Penachioni, J. Y., Korostylev, A., Swiercz, J. M., Vodrazka, P., Mauti, O., Stoeckli, E. T., Tamagnone, L., et al. (2007) · Journal of Neuroscience

Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

Cited by 121

Lineage tracing of cells involved in atherosclerosis

Albarrán-Juárez, J., Kaur, H., Grimm, M., Offermanns, S., & Wettschureck, N. (2016) · Atherosclerosis

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 90

Targeting of Scavenger Receptors Stabilin-1 and Stabilin-2 Ameliorates Atherosclerosis by a Plasma Proteome Switch Mediating Monocyte/Macrophage Suppression

Manta, C.-P., Leibing, T., Friedrich, M., Nolte, H., Adrian, M., Schledzewski, K., Krzistetzko, J., Kirkamm, C., David Schmid, C., Xi, Y., et al. (2022) · Circulation

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 84

The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice.

Sassmann, A., Gier, B., Gröne, H.-J., Drews, G., Offermanns, S., & Wettschureck, N. (2010) · Journal of Clinical Investigation

Pancreatic function and diabetesAdenosine and Purinergic Signaling

Cited by 75

Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance

Bae, H., Hong, K. Y., Lee, C.-K., Jang, C., Lee, S.-J., Choe, K., Offermanns, S., He, Y., Lee, H. J., & Koh, G. Y. (2020) · Nature Communications

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 52

Heterotrimeric G Proteins of the Gq/11 Family Are Crucial for the Induction of Maternal Behavior in Mice

Wettschureck, N., Moers, A., Hamalainen, T., Lemberger, T., Schütz, G., & Offermanns, S. (2004) · Molecular and Cellular Biology

Neuroendocrine regulation and behaviorHypothalamic control of reproductive hormones

Cited by 46

A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib

Sun, T., Yang, L., Kaur, H., Pestel, J., Looso, M., Nolte, H., Krasel, C., Heil, D., Krishnan, R. K., Santoni, M.-J., et al. (2017) · Journal of Cell Biology

Axon Guidance and Neuronal SignalingChemokine receptors and signaling

Cited by 44

The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology

Simonetti, M., Paldy, E., Njoo, C., Bali, K. K., Worzfeld, T., Pitzer, C., Kuner, T., Offermanns, S., Mauceri, D., & Kuner, R. (2021) · Molecular Psychiatry

Memory and Neural MechanismsAxon Guidance and Neuronal Signaling

Cited by 41

Nanobody inhibitors of Plexin-B1 identify allostery in plexin–semaphorin interactions and signaling

Cowan, R., Trokter, M., Oleksy, A., Fedorova, M., Sawmynaden, K., Worzfeld, T., Offermanns, S., Matthews, D., Carr, M. D., & Hall, G. (2023) · Journal of Biological Chemistry

Axon Guidance and Neuronal SignalingReceptor Mechanisms and Signaling

Cited by 11

Zonated mechanosensing by PIEZO1 controls liver regeneration

Zhang, Y., Sun, Y., Xu, G., Wu, Y., Shi, Z., Chang, Z., Liu, J., Pang, K., Liu, S., Wang, H., et al. (2026) · Science

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 5