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Do We Age on Sirt1 Expression?
Abstract
Aging leads to a progressive decline in multiple organsystems, including the heart. Heart failure in responseto cellular aging and chronic or acute cellular stresses represents one of the major burdens of the western civiliza-tion. Over the last 15 years, the interest in the therapeutic use of caloric restriction to prevent aging has emerged. However, it is difficult to determine whether caloric restriction influ-ences longevity in humans because no validated biomarker exists, which can serve as a surrogate marker of aging and it is impossible to conduct a randomized, diet-controlled long-term survival study in humans. Nevertheless, caloric restric-tion has been shown in several studies to lower fasting plasma glucose concentration and serum low-density lipoprotein cholesterol, to decrease insulin resistance, visceral fat mass and the levels of inflammatory markers. Most of these markers are known to be risk factors for coronary heart disease. Thus, even it is not known whether caloric restriction
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The SIRT-1 agonist resveratrol ameliorated ageing pathology, in part by activating FOXO3.
“The SIRT-1 agonist resveratrol ameliorated ageing pathology, in part by activating FOXO3.33,155”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [155]
More than 12.5-fold overexpression of FOXO3 has been shown to be harmful, possibly because of NAD depletion.
“Importantly, more than 12.5-fold overexpression of FOXO3 has been shown to be harmful, possibly because of nicotinamide adenine dinucleotide (NAD) depletion155; thus, a careful dose-finding study is imperative.”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [155]
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Metadata
- Authors
- Sedding, D., & Haendeler, J.
- Affiliations
- Justus-Liebig-Universität Gießen (DE)
- Venue
- Circulation Research
- Published
- 2007-05-25
- Volume
- 100
- Issue
- 10
- Pages
- 1396-1398
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2095661824
- Cited by
- 21
- References
- 17
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 4
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB-547)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- SIRT1, aging, caloric restriction, heart failure, cellular aging, aging biomarkers, longevity, insulin resistance, inflammation, coronary risk factors
- MeSH terms
- Forkhead Box Protein O1, Resveratrol, Aging, Humans, Longevity, Myocardium, Stilbenes, Oxidative Stress, Caloric Restriction, Sirtuins, Forkhead Transcription Factors, Sirtuin 1
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