Blood Fibrinolytic Activity in Man: Diurnal Variation and the Response to Varying Intensities of Exercise
Open accessAbstract
This investigation was undertaken in normal subjects to define the relationship between the intensity of exercise and magnitude of fibrinolytic response and to examine the effect of diurnal variations on the exercise response. Fibrinolytic activity was measured on fibrin plates and expressed as mm 2 . Diurnal variations occurred with lowest activity at 8:00 AM (mean, 66 mm 2 ), and peak activity between 5:00 and 8:00 PM (mean, 266 mm 2 , P <0.001). Five minutes of maximal treadmill exercise caused a marked increase in mean activity from 90 to 658 mm 2 ( P <0.001). Five minutes of 70% maximal exercise produced no significant increase, but 30 minutes increased activity to 626 mm 2 ( P <0.005). In contrast, 30 minutes of 40% maximal exercise produced a small elevation from 80 to 173 mm 2 ( P <0.005). Maximal and 40% maximal exercise evoked greater responses at 4:00 PM than 8:00 AM . Exercise produces increases in fibrinolytic activity which are related to the relative intensity of exercise, its duration, and the time of day it is performed. Short bursts of intense exercise cause marked increases, but more prolonged bouts of moderate exercise are required to produce similar increases. The increases with prolonged mild exercise are small and comparable to those observed during resting diurnal variations.
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Other potential triggers, such as psychological stress or anger, which produce similar physiologic responses, are more common than heavy exertion before myocardial infarction and may be more frequent triggers.
“Furthermore, other potential triggers, such as psychological stress or anger, which produce similar physiologic 38-41 are more common than heavy exertion responses,3 before myocardial infarction¹,³ and may be more frequent triggers.”
From Triggering of Acute Myocardial Infarction by Heavy Physical Exertion -- Protection against Triggering by Regular Exertion (1993) · cites this paper as [38]
The Abstract and “Varying Levels of Exercise” section say that exercise and anxiety or mental stress can both increase blood fibrinolytic activity, supporting a shared physiological response. The paper does not establish that stress or anger occurs more often than heavy exertion before myocardial infarction or is a more frequent trigger. Page numbers are unavailable in our copy. (LLM, conf=0.85)
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Research works printed but not linked: 2
- ASTRUP, T.: Blood coagulation, fibrinolysis and the development of the thrombogenic theory of arteriosclerosis. Le Role de la Paroi Arterielle dans l'Atherogenese, (Transactions of Confer- ence), Centre National de la Rechereche Scientifique, Paris, June 15-17, 1967, p. 535.
- BRAKMAN, P., MOHLEH, E. R., AND ASTRUP, T.: Downloaded from http://ahajournals.org by on August 17, 2026 Group of patients with impaired plasma associated with surgical operations, trauma, fibrinolytic system and selective inhibition of etc. Lancet 2: 862, 1946. tissue activator-induced fibrinolysis. Scand J 23. FEABNLEY, G. R., CHAKRABABTL, R., AND EVANS, Haemat 3: 389, 1966.
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- Authors
- ROSING, D. R., BRAKMAN, P., REDWOOD, D. R., GOLDSTEIN, R. E., BEISER, G. D., ASTRUP, T., & EPSTEIN, S. E.
- Affiliations
- National Heart, Lung, and Blood Institute (US)
- St George's Hospital (GB)
- ORCID
- GOLDSTEIN, ROBERT E.
- Venue
- Circulation Research
- Published
- 1970-08
- Volume
- 27
- Issue
- 2
- Pages
- 171-184
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2052760576
- Cited by
- 226
- References
- 0
- Citations by year
- 2026: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 1
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (20014)
- St. George's, University of London
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- fibrinolysis, fibrinolytic activity, exercise intensity, exercise duration, diurnal variation, fibrin plate assay, treadmill exercise, hemostasis, fibrinogen
- MeSH terms
- Adult, Arteries, Circadian Rhythm, Physical Exertion, Fasting, Female, Fibrin, Fibrinogen, Fibrinolysis, Fibrinolytic Agents, Food, Humans, Male, Oxygen Consumption, Plasminogen, Rest, Time Factors, Veins
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