Cited by 937Nitric Oxide and Endothelin EffectsCardiovascular and exercise physiologyCardiovascular Health and Disease Prevention

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Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression.

Sessa, W C, Pritchard, K, Seyedi, N, Wang, J, Hintze, T H·1994·Circulation Research

DOI 10.1161/01.res.74.2.349

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Abstract

Recently, we have shown that chronic exercise increases endothelium-derived relaxing factor (EDRF)/nitric oxide (NO)-mediated epicardial coronary artery dilation in response to brief occlusion and acetylcholine. This finding suggests that exercise can provide a stimulus for the enhanced production of EDRF/NO, thus possibly contributing to the beneficial effects of exercise on the cardiovascular system. Therefore, the purpose of the present study was to examine whether chronic exercise could influence the production of NO (measured as the stable degradation product, nitrite) and endothelial cell NO synthase (ECNOS) gene expression in vessels from dogs after chronic exercise. To this end, dogs were exercised by running on a treadmill (9.5 km/h for 1 hour, twice daily) for 10 days, and nitrite production in large coronary vessels and microvessels and ECNOS gene expression in aortic endothelial extracts were assessed. Acetylcholine (10(-7) to 10(-5) mol/L) dose-dependently increased the release of nitrite (inhibited by nitro-L-arginine) from coronary arteries and microvessels in control and exercised dogs. Moreover, acetylcholine-stimulated nitrite production was markedly enhanced in large coronary arteries and microvessels prepared from hearts of dogs after chronic exercise compared with hearts from control dogs. One potential mechanism that may contribute to the enhanced production of nitrite in vessels from exercised dogs may be the induction of the calcium-dependent ECNOS gene. Steady-state mRNA levels for ECNOS were significantly higher than mRNA levels for von Willebrand's factor (vWF, a specific endothelial cell marker) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH, a constitutively expressed gene) in exercised dogs.(ABSTRACT TRUNCATED AT 250 WORDS)

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Items 201–300 of 937

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Self-citation
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Background
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Method
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Result
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Method
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Background
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“This hypothesis is also supported by the recent observation that sustained exercise in dogs increased endothelial NO synthase gene expression and coronary vascular NO production (32).”
Result
Increased expression of constitutive nitric oxide synthase III, but not inducible nitric oxide synthase II, in human heart failure 11During publication process the following related paper has been published by Vejlstrup NG, Bouloumie A, Boesgaard S, Andersen CB, Nielsen-Kudsk JE, Mortensen SA, Kent JD, Harrison DG, Busse R, Alsershvile J. Inducible nitric oxide synthase (iNOS) in the human heart: Expression and localization in congestive heart failure. J Mol Cell Cardiol 1998;30:1215–23.
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Background
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Background
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Background
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Background
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“Our data show for the first time the chronic exercise-induced upregulation of endogenous pulmonary eNOS expression in PAH, which has previously been demonstrated in healthy animals and models of systemic vascular disease (34, 36, 52, 65).”
Result
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Self-citation
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Background
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Background
Regular physical exercise improves endothelial function in heart transplant recipients
Schmidt, A., Pleiner, J., Bayerle‐Eder, M., Wiesinger, G., Rödler, S., Quittan, M., Mayer, G. J., & Wolzt, M. (2002) · Clinical Transplantation · doi:10.1034/j.1399-0012.2002.1o100.x · Cited by 76
“Training may cause enhanced NO synthase gene expression and higher NO production as shown in a dog model (30), which was associated with increased endothelium-dependent dilation of coronary arteries (31).”
Background
Enhanced Endothelium-Dependent Relaxations After Gene Transfer of Recombinant Endothelial Nitric Oxide Synthase to Rabbit Carotid Arteries
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Targeting of human eNOS promoter to the Hprt locus of mice leads to tissue-restricted transgene expression
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“Despite its designation as a constitutive enzyme, eNOS is upregulated by many extracellular signals, including growth factors, hormones, shear stress and hypoxia (3, 12, 16, 18, 20, 22, 25, 28).”
Background
Exercise training reverses age-related decrements in endothelium-dependent dilation in skeletal muscle feed arteries
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Blood Flow Restricted Exercise and Vascular Function
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“Animal studies showed that prolonged training induces structural changes, namely, “arterial remodeling” [165, 166], while short-term training improves vascular function via enhanced NO bioavailability [167–170].”
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“Exercise training increases expression of endothelial nitric oxide (NO) synthase (NOS-3) in coronary vasculature (Sessa et al. 1994), and neuronal NOS (NOS-1) in cardiac sympathetic ganglia (Mohan et al.”
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Up-regulation of renal and vascular nitric oxide synthase in iron-deficiency anemia
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“Previous studies have found that shortterm training can increase the bioavailability of eNOS and NO, thereby improving vascular endothelial function (Sessa et al., 1994; Sun et al., 1994; Kingwell et al., 1997).”
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Smad2 Mediates Transforming Growth Factor-β Induction of Endothelial Nitric Oxide Synthase Expression
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Gender, exercise training, and eNOS expression in porcine skeletal muscle arteries
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“(17), in dog aorta and coronary arteries (50, 59), and”
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The role of endothelium-derived vasoactive substances in the pathophysiology of exercise intolerance in patients with congestive heart failure
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Effects of short-term endurance exercise training on vascular function in young males
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“1993), with increases in endothelial NO synthase (eNOS) gene expression occurring after 10 days (Sessa et al. 1994).”
Background
Beneficial effects of exercise training after myocardial infarction require full eNOS expression
de Waard, M. C., van Haperen, R., Soullié, T., Tempel, D., de Crom, R., & Duncker, D. J. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.02.005 · Cited by 70
l -Arginine enhances aerobic exercise capacity in association with augmented nitric oxide production
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Endurance, interval sprint, and resistance exercise training: impact on microvascular dysfunction in type 2 diabetes
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EFFECTS OF EXERCISE TRAINING ON VASCULAR FUNCTION AND MYOCARDIAL PERFUSION
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Endothelium-Mediated Relaxation of Porcine Collateral-Dependent Arterioles Is Improved by Exercise Training
Griffin, K. L., Woodman, C. R., Price, E. M., Laughlin, M. H., & Parker, J. L. (2001) · Circulation · doi:10.1161/hc3601.094274 · Cited by 67
Physical inactivity causes endothelial dysfunction in healthy young mice
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“Recently, it has become apparent that xercise induces an increased expression of vascular endohelial nitric oxide synthase (eNOS) as well (4,5).”
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Aortic Stiffness and Aerobic Exercise: Mechanistic Insight from Microarray Analyses
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“…produce substan- tial changes in eNOS expression in systemic arteries and the coronary circulation of large mammals (Hambrecht et al., 2000; Laughlin, 1985; Laughlin et al., 1996; 2001; Sessa et al., 1994; Wang et al., 1993) and in mice (Davis et al., 2003; Fukai et al., 2000; Kojda et al., 2001).”
Background
Chronic exercise enhances endothelium-mediated dilation in spontaneously hypertensive rats
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The 67-kDa Laminin-binding Protein Is Involved in Shear Stress-dependent Endothelial Nitric-oxide Synthase Expression
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Exercise enhances vasorelaxation in experimental obesity associated hypertension
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Exercise training improves endothelium-mediated vasorelaxation after chronic coronary occlusion
Griffin, K. L., Laughlin, M. H., & Parker, J. L. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.5.1948 · Cited by 65
“Because exercise training has been associated with increases in nitric oxide (NO) (2, 18, 21) and endothelial cell NO synthase (ecNOS) gene expression (31, 36) in arteries isolated from normal nonoccluded hearts, we also sought to evaluate the role of NO in mediating vasorelaxation in our model of chronic coronary occ…”
BackgroundMethod

Authors: Sessa, W. C., Pritchard, K., Seyedi, N., Wang, J., & Hintze, T. H.
Affiliations: New York Medical College (US)
ORCID: Sessa, W C
Pritchard, K
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1994-02
Volume: 74
Issue: 2
Pages: 349-353
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/01.res.74.2.349
OpenAlex: W2125823894
Cited by: 934
References: 0
Citations by year: 2026: 2 · 2025: 6 · 2024: 11 · 2023: 8 · 2022: 10 · 2021: 14 · 2020: 17 · 2019: 15 · 2018: 11 · 2017: 11 · 2016: 18 · 2015: 29 · 2014: 18 · 2013: 16 · 2012: 27
FWCI: 32.87
Type: journal article
Language: en
Open access: closed
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Heart, Lung, and Blood Institute (P01HL043023, P01 HL 43023)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: exercise training, nitric oxide, endothelial nitric oxide synthase, coronary arteries, coronary microvessels, nitrite production, endothelium-derived relaxing factor, acetylcholine, von Willebrand factor, aortic endothelial cells, treadmill running, dogs
MeSH terms: Amino Acid Oxidoreductases, Animals, Coronary Vessels, Dogs, Endothelium, Vascular, Physical Exertion, Female, Male, Nitric Oxide, Nitrites, RNA, Time Factors, Gene Expression, Nitric Oxide Synthase

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Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression.

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