Cited by 937Nitric Oxide and Endothelin EffectsCardiovascular and exercise physiologyCardiovascular Health and Disease Prevention

The DOI matches its Crossref record.

Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression.

Sessa, W C, Pritchard, K, Seyedi, N, Wang, J, Hintze, T H·1994·Circulation Research

DOI 10.1161/01.res.74.2.349

Open this paper in CoChat — free account

Abstract

Recently, we have shown that chronic exercise increases endothelium-derived relaxing factor (EDRF)/nitric oxide (NO)-mediated epicardial coronary artery dilation in response to brief occlusion and acetylcholine. This finding suggests that exercise can provide a stimulus for the enhanced production of EDRF/NO, thus possibly contributing to the beneficial effects of exercise on the cardiovascular system. Therefore, the purpose of the present study was to examine whether chronic exercise could influence the production of NO (measured as the stable degradation product, nitrite) and endothelial cell NO synthase (ECNOS) gene expression in vessels from dogs after chronic exercise. To this end, dogs were exercised by running on a treadmill (9.5 km/h for 1 hour, twice daily) for 10 days, and nitrite production in large coronary vessels and microvessels and ECNOS gene expression in aortic endothelial extracts were assessed. Acetylcholine (10(-7) to 10(-5) mol/L) dose-dependently increased the release of nitrite (inhibited by nitro-L-arginine) from coronary arteries and microvessels in control and exercised dogs. Moreover, acetylcholine-stimulated nitrite production was markedly enhanced in large coronary arteries and microvessels prepared from hearts of dogs after chronic exercise compared with hearts from control dogs. One potential mechanism that may contribute to the enhanced production of nitrite in vessels from exercised dogs may be the induction of the calcium-dependent ECNOS gene. Steady-state mRNA levels for ECNOS were significantly higher than mRNA levels for von Willebrand's factor (vWF, a specific endothelial cell marker) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH, a constitutively expressed gene) in exercised dogs.(ABSTRACT TRUNCATED AT 250 WORDS)

Integrity signals

Registry

Crossref · 10.1161/01.res.74.2.349

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 101–200 of 937

Sustained Increase in Aortic Endothelial Nitric Oxide Synthase Expression In Vivo in a Model of Chronic High Blood Flow
Nadaud, S., Philippe, M., Arnal, J., Michel, J., & Soubrier, F. (1996) · Circulation Research · doi:10.1161/01.res.79.4.857 · Cited by 221
Exercise, Vascular Wall and Cardiovascular Diseases: An Update (Part 1)
Leung, F. P., Yung, L. M., Laher, I., Yao, X., Chen, Z. Y., & Huang, Y. (2008) · Sports Medicine · doi:10.2165/00007256-200838120-00005 · Cited by 219
Effects of exercise training on vascular function in obese children
Watts, K., Beye, P., Siafarikas, A., O’Driscoll, G., Jones, T. W., Davis, E. A., & GREEN, D. J. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.02.027 · Cited by 211
A New In Vitro Model to Evaluate Differential Responses of Endothelial Cells to Simulated Arterial Shear Stress Waveforms
Blackman, B. R., García‐Cardeña, G., & Gimbrone, M. A. (2002) · Journal of Biomechanical Engineering · doi:10.1115/1.1486468 · Cited by 211
Kinins and Endothelial Control of Vascular Smooth Muscle
Mombouli, J., & Vanhoutte, P. M. (1995) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.003335 · Cited by 209
Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression
Searles, C. D. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00457.2005 · Cited by 208
“Increased expression of eNOS has been observed in surgically created animal models for high flow (9, 87, 98) and in exercise-training studies (61, 127, 129, 135, 151).”
Background
Effects of ageing and exercise training on endothelium‐dependent vasodilatation and structure of rat skeletal muscle arterioles
Spier, S. A., Delp, M. D., Meininger, C. J., Donato, A. J., Ramsey, M. W., & Muller‐Delp, J. M. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.060301 · Cited by 209
“…in young adult animals is associated with greater endothelium-dependent vasodilatation and eNOS mRNA and protein expression in the aorta and coronary resistance arteries (Delp et al. 1993; Muller et al. 1994; Sessa et al. 1994; Delp & Laughlin, 1997; Woodman et al. 1997; Kojda et al. 2001).”
BackgroundResultInfluential
Acute exposure to waterborne cadmium induced oxidative stress and immunotoxicity in the brain, ovary and liver of zebrafish ( Danio rerio )
Zheng, J., Yuan, S.-S., Wu, C., & Lv, Z. (2016) · Aquatic Toxicology · doi:10.1016/j.aquatox.2016.09.012 · Cited by 206
Obesity, the metabolic syndrome, and sexual dysfunction
Esposito, K., & Giugliano, D. (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901333 · Cited by 196
Impairment of vascular endothelial nitric oxide synthase activity by advanced glycation end products
Biao, X., Chibber, R., Ruggiero, D., Kohner, E., Ritter, J., & Ferro, A. (2003) · The FASEB Journal · doi:10.1096/fj.02-0490fje · Cited by 195
Pharmacodynamics of Plasma Nitrate/Nitrite as an Indication of Nitric Oxide Formation in Conscious Dogs
Zeballos, G. A., Bernstein, R. D., Thompson, C. I., Forfia, P. R., Seyedi, N., Shen, W., Kaminski, P. M., Wolin, M. S., & Hintze, T. H. (1995) · Circulation · doi:10.1161/01.cir.91.12.2982 · Cited by 194
Self-citation
Nitric oxide and vasodilation in human limbs
Joyner, M. J., & Dietz, N. M. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.6.1785 · Cited by 192
“, the aorta) that are subject to increased flow during exercise (21, 91).”
Background
EXERCISE AND AUTONOMIC FUNCTION IN HEALTH AND CARDIOVASCULAR DISEASE
Rosenwinkel, E. T., Bloomfield, D. M., Arwady, M. A., & Goldsmith, R. L. (2001) · Cardiology Clinics · doi:10.1016/s0733-8651(05)70223-x · Cited by 194
Characterization of drugs as antioxidant prophylactics
Aruoma, O. I. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02110-8 · Cited by 187
Control of Blood Flow to Cardiac and Skeletal Muscle During Exercise
Laughlin, M. H., Korthuis, R. J., Duncker, D. J., & Bache, R. J. (1996) · Comprehensive physiology · doi:10.1002/cphy.cp120116 · Cited by 189
Molecular control of nitric oxide synthases in the cardiovascular system
Papapetropoulos, A. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00161-3 · Cited by 186
Nitric Oxide Synthases: Gene Structure and Regulation
Wang, Y., & Marsden, P. A. (1995) · Advances in pharmacology · doi:10.1016/s1054-3589(08)61081-9 · Cited by 187
Endothelial nitric oxide synthase: the Cinderella of inflammation?
Cirino, G., Fiorucci, S., & Sessa, W. C. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)00049-4 · Cited by 182
Self-citation
Induction of nitric oxide synthase mRNA in coronary resistance arteries isolated from exercise-trained pigs
Woodman, C. R., Muller‐Delp, J. M., Laughlin, M. H., & Price, E. M. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.6.h2575 · Cited by 184
“Although exercise training has been shown to elicit an increase in the expression of ecNOS mRNA in canine aorta (11), the effect of exercise training on the expression of this gene in coronary resistance arteries is not known.”
BackgroundInfluential
Enhanced Release of Prostaglandins Contributes to Flow-Induced Arteriolar Dilation in eNOS Knockout Mice
Sun, D., Huang, A., Smith, C. J., Stackpole, C. J., Connetta, J. A., Shesely, E. G., Koller, A., & Kaley, G. (1999) · Circulation Research · doi:10.1161/01.res.85.3.288 · Cited by 186
eNOS phosphorylation in health and disease
Kolluru, G. K., Siamwala, J. H., & Chatterjee, S. (2010) · Biochimie · doi:10.1016/j.biochi.2010.03.020 · Cited by 183
Endothelial NOS: perspective and recent developments
Garcia, V. G., & Sessa, W. C. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14522 · Cited by 184
“Most importantly, eNOS gene expression is up-regulated by fluid shear stress (Nishida et al., 1992) and cyclic stretch (Awolesi et al., 1995) in cultured endothelial cells (EC), and this has been observed also in exercised animals (Sessa et al., 1994; Fukai et al., 2000).”
BackgroundSelf-citation
Daily Aerobic Exercise Improves Reactive Hyperemia in Patients With Essential Hypertension
Higashi, Y., Sasaki, S., Sasaki, N., Nakagawa, K., Ueda, T., Yoshimizu, A., Kurisu, S., Matsuura, H., Kajiyama, G., & Oshima, T. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.591 · Cited by 182
An Obligation for Primary Care Physicians to Prescribe Physical Activity to Sedentary Patients to Reduce the Risk of Chronic Health Conditions
Chakravarthy, M. V., Joyner, M. J., & Booth, F. W. (2002) · Mayo Clinic Proceedings · doi:10.4065/77.2.165 · Cited by 217
Exercise-induced improvement in endothelial dysfunction is not mediated by changes in CV risk factors: pooled analysis of diverse patient populations
GREEN, D. J., Walsh, J. H., Maiorana, A., Best, M. J., Taylor, R. R., & O'Driscoll, J. G. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00519.2003 · Cited by 178
“Animal studies have found that exercise training is associated with an increase in vascular NO production (45, 48) and upregulation of NO synthase expression (45), attributable to repeated episodes of vascular wall shear stress.”
Background
The Link Among Nitric Oxide Synthase Activity, Endothelial Function, and Aortic and Ventricular Hypertrophy in Hypertension
Hayakawa, H., & Raij, L. R. (1997) · Hypertension · doi:10.1161/01.hyp.29.1.235 · Cited by 177
The Janus Face of VEGF in Stroke
Geiseler, S. J., & Morland, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051362 · Cited by 179
Novel Vascular Biology of Third-Generation L-Type Calcium Channel Antagonists
Mason, R. P., Marché, P., & Hintze, T. H. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000097770.66965.2a · Cited by 173
Self-citation
Effects of Different Types of Exercise Training Followed by Detraining on Endothelium-Dependent Dilation in Patients With Recent Myocardial Infarction
Vona, M., Codeluppi, G. M., Iannino, T., Ferrari, E., Bogousslavsky, J., & von Segesser, L. K. (2009) · Circulation · doi:10.1161/circulationaha.108.821736 · Cited by 167
Is exercise training an effective therapy targeting endothelial dysfunction and vascular wall inflammation?
Ribeiro, F., Alves, A. J., Duarte, J. A., & Oliveira, J. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.09.548 · Cited by 169
“Studies using animal experiments [45,46] and cultured endothelial cells [47,48] suggested that shear stress increases eNOS expression/activity, probably due to the stabilization of eNOS mRNA [47] or the presence of transcription factors in the promoter region of eNOS gene enhancing the synthesis of mRNA [49].”
Background
Coenzyme Q10 and exercise training in chronic heart failure
Belardinelli, R., Muçaj, A., Lacalaprice, F., Solenghi, M., Seddaiu, G., Principi, F., Tiano, L., & Littarru, G. P. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl158 · Cited by 167
“Furthermore, the improvement in LV contractility after ET has been related to enhanced coronary collateralization, which is modulated by nitric oxide.(39,40) We did not use pharmacological compounds, acetylcholine and N-monomethyl-L-arginine, to study the effects of CoQ10 alone or in combination with ETon the endothel…”
Background
Moderate Regular Exercise Increases Basal Production of Nitric Oxide in Elderly Women
Maeda, S., Tanabe, T., Otsuki, T., Sugawara, J., Iemitsu, M., Miyauchi, T., Kuno, S., Ajisaka, R., & Matsuda, M. (2004) · Hypertension Research · doi:10.1291/hypres.27.947 · Cited by 168
“Animal studies, however, have reported that exercise training increased the expression of endothelial NOS (eNOS) mRNA in the dog aorta (37) and the expression of eNOS protein in the rat aorta (38).”
Background
The l-arginine—nitric oxide pathway: role in atherosclerosis and therapeutic implications
Böger, R. H., Bode‐Böger, S. M., & Frölich, J. C. (1996) · Atherosclerosis · doi:10.1016/s0021-9150(96)05953-9 · Cited by 168
Neural regulation of sympathetic nerve activity in heart failure
Zucker, I. H., Wang, W., Brändle, M., Schultz, H. D., & Patel, K. P. (1995) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(05)80020-9 · Cited by 165
Time course of enhanced endothelium-mediated dilation in aorta of trained rats
Delp, M. D., & Laughlin, M. H. (1997) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199711000-00011 · Cited by 166
Exercise training regulates SOD-1 and oxidative stress in porcine aortic endothelium
Rush, J. W. E., Turk, J. R., & Laughlin, M. H. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00190.2002 · Cited by 165
“, increased eNOS levels and activity) after training (7, 31, 37, 45).”
Background
Training improves endothelium-dependent vasodilation in resistance vessels of patients with heart failure
Katz, S. D., Yuen, J., Bijou, R., & LeJemtel, T. H. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.5.1488 · Cited by 164
“Alterations in regulation of vascular resistance associated with training include increased endothelium-dependent vasodilation in both conduit and resistance blood vessels, increased nitric oxide synthesis in microvessels, and increased levels of endothelial nitric oxide synthase mRNA (3, 22, 26).”
Background
Nitric Oxide and Its Putative Role in Hypertension
Dominiczak, A. F., & Bohr, D. F. (1995) · Hypertension · doi:10.1161/01.hyp.25.6.1202 · Cited by 162
Regulation and Functional Consequences of Endothelial Nitric Oxide Formation
Busse, R., & Fleming, I. (1995) · Annals of Medicine · doi:10.3109/07853899509002586 · Cited by 166
Endothelial function as a determinant of vascular function and structure: A new therapeutic target
Gibbons, G. H. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00122-7 · Cited by 162
Physical Training Improves Flow-Mediated Dilation in Patients With the Polymetabolic Syndrome
Lavrenc̆ic̆, A., Salobir, B., & Keber, I. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.2.551 · Cited by 159
Vascular nitric oxide and oxidative stress: determinants of endothelial adaptations to cardiovascular disease and to physical activity.
Rush, J., Denniss, S., & Graham, D. A. (2005) · Canadian Journal of Applied Physiology · doi:10.1139/h05-133 · Cited by 165
“…function that results from exercise training (Delp et al., 1993; Delp and Laughlin, 1997; Graham and Rush, 2004; Hambrecht et al., 1998; 2000; Higashi et al., 1999a; 1999b; Kingwell et al., 1996; Muller et al., 1994; Rush et al., 2000; 2003; Sessa et al., 1994; Woodman et al., 1997; 1999).”
BackgroundInfluential
Training induces nonuniform increases in eNOS content along the coronary arterial tree
Laughlin, M. H., Pollock, J. S., Amann, J. F., HOLLIS, M., Woodman, C. R., & Price, E. M. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.2.501 · Cited by 159
Regulation of Endothelial Constitutive Nitric Oxide Synthase by Protein Kinase C
Ohara, Y., Sayegh, H. S., Yamin, J. J., et al. (1995) · Hypertension · doi:10.1161/01.hyp.25.3.415 · Cited by 159
In Vivo Quantification of Blood Flow and Wall Shear Stress in the Human Abdominal Aorta During Lower Limb Exercise
Taylor, C. A., Cheng, C. P., Espinosa, L. A., Tang, B. T., Parker, D., & Herfkens, R. J. (2002) · Annals of Biomedical Engineering · doi:10.1114/1.1476016 · Cited by 157
Enhanced external counterpulsation improved myocardial perfusion and coronary flow reserve in patients with chronic stable angina. Evaluation by13N-ammonia positron emission tomography
Masuda, D. (2001) · European Heart Journal · doi:10.1053/euhj.2000.2545 · Cited by 157
“A previous study showed that exercising for 10 days increased the gene expression of endothelial nitric oxide synthase in a dog([16]).”
Background
Endomyocardial Nitric Oxide Synthase and Left Ventricular Preload Reserve in Dilated Cardiomyopathy
Heymes, C., Vanderheyden, M., Bronzwaer, J. G. F., Shah, A. M., & Paulus, W. J. (1999) · Circulation · doi:10.1161/01.cir.99.23.3009 · Cited by 157
Effects of Exercise Training and Deconditioning on Platelet Function in Men
Wang, J., Jen, C. J., & Chen, H. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.10.1668 · Cited by 155
Self-citation
Regulation of Nitric Oxide Production in Human Coronary Microvessels and the Contribution of Local Kinin Formation
Kichuk, M. R., Seyedi, N., Zhang, X., Marboe, C. C., Michler, R. E., Addonizio, L. J., Kaley, G., Nasjletti, A., & Hintze, T. H. (1996) · Circulation · doi:10.1161/01.cir.94.1.44 · Cited by 153
Self-citation
Exercise training improves conduit vessel function in patients with coronary artery disease
Walsh, J. H., Bilsborough, W., Maiorana, A., Best, M., O’Driscoll, G., Taylor, R. R., & GREEN, D. J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00012.2003 · Cited by 155
“Animal studies have found that exercise training is associated with an increase in vascular NO production (30, 32) and upregulation of NO synthase expression (30), again attributable to repeated episodes of vascular wall shear stress.”
Background
Endothelial Nitric Oxide Synthase
Tai, S. C., Robb, G. B., & Marsden, P. A. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000109171.50229.33 · Cited by 154
A high-fat, refined-carbohydrate diet induces endothelial dysfunction and oxidant/antioxidant imbalance and depresses NOS protein expression
Roberts, C. K., Barnard, R. J., Sindhu, R. K., Jurczak, M. J., Ehdaie, A., & Vaziri, N. D. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00463.2004 · Cited by 150
“Thus we hypothesize that in the early phase, before onset of hypertension, diet-induced oxidative stress and eNOS deficiency promote endothelial dysfunction, whereas in the latter phase (2 yr), when hypertension has developed, eNOS may be upregulated possibly by increased shear stress and/or as a compensatory attempt…”
Background
NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats
Wiest, R., Shah, V. H., Sessa, W. C., & Groszmann, R. J. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.4.g1043 · Cited by 149
“Chronic high blood flow has been demonstrated to increase aortic eNOS expression and NO production (37, 47), suggesting that increased NO synthesis is a normal chronic adaptive mechanism of the endothelium in response to chronic increases in flow-induced shear stress.”
BackgroundSelf-citation
Mechanisms by which exercise training benefits patients with heart failure
Crimi, E., Ignarro, L. J., Cacciatore, F., & Claudio Napoli, A. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.8 · Cited by 146
Physical training in patients with chronic heart failure enhances the expression of genes encoding antioxidative enzymes
Ennezat, P. V., Malendowicz, S. L., Testa, M., Colombo, P. C., Solal, A. C., Evans, T., & LeJemtel, T. H. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01321-3 · Cited by 147
“In the same pacing model, exercising 2 h per day for 10 consecutive days increased expression of eNOS in the aorta (5).”
Background
Endothelial cytosolic proteins bind to the 3′ untranslated region of endothelial nitric oxide synthase mRNA: regulation by tumor necrosis factor alpha
Alonso, J., Sánchez de Miguel, L., Montón, M., Casado, S., & López-Farré, A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.10.5719 · Cited by 146
Vascular endothelium: Vasoactive mediators
Vanhoutte, P. M., & Mombouli, J. (1996) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(96)80003-x · Cited by 142
Repetition of Ischemic Preconditioning Augments Endothelium-Dependent Vasodilation in Humans
Kimura, M., Ueda, K., Goto, C., Jitsuiki, D., Nishioka, K., Umemura, T., Noma, K., Yoshizumi, M., Chayama, K., & Higashi, Y. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.143578 · Cited by 153
Dysfunctional Regulation of Endothelial Nitric Oxide Synthase (eNOS) Expression in Response to Exercise in Mice Lacking One eNOS Gene
Kojda, G., Cheng, Y. C., Burchfield, J. S., & Harrison, D. G. (2001) · Circulation · doi:10.1161/01.cir.103.23.2839 · Cited by 143
Basal Release of Nitric Oxide Augments the Frank-Starling Response in the Isolated Heart
Prendergast, B., Sagach, V. F., & Shah, A. M. (1997) · Circulation · doi:10.1161/01.cir.96.4.1320 · Cited by 142
Dietary Nitrate, Nitric Oxide, and Cardiovascular Health
Bondonno, C. P., Croft, K. D., & Hodgson, J. M. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.811212 · Cited by 141
Exercise Improves Flow-Mediated Vasodilatation of Skeletal Muscle Arteries in Rats With Chronic Heart Failure
Varin, R., Mulder, P. G. H., Richard, V. J., Tamion, F., Devaux, C., Henry, J., Lallemand, F., Lerebours, G., & Thuillez, C. (1999) · Circulation · doi:10.1161/01.cir.99.22.2951 · Cited by 141
EDHF: new therapeutic targets?
Félétou, M. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2003.10.017 · Cited by 136
Association between wall shear stress and flow-mediated vasodilation in healthy men
Gnasso, A., Carallo, C., Irace, C., Franceschi, M. S. D., Mattioli, P. L., Motti, C., & Cortese, C. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00617-1 · Cited by 138
Skeletal muscle nNOSμ protein content is increased by exercise training in humans
McConell, G. K., Bradley, S. J., Stephens, T. J., Canny, B. J., Kingwell, B. A., & Lee-Young, R. S. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00796.2006 · Cited by 136
“The higher skeletal muscle nNOS protein expression after exercise training is likely to be associated with greater production of NO by skeletal muscle (38, 40, 43).”
Background
Mechanisms of Dysfunction of the Nitric Oxide Pathway in Vascular Diseases
Maxwell, A. J. (2002) · Nitric Oxide · doi:10.1006/niox.2001.0394 · Cited by 136
Effects of exercise training on the cardiovascular system: Pharmacological approaches
Zanesco, A., & Antunes, E. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.03.010 · Cited by 135
Role of Arterial Wall Antioxidant Defense in Beneficial Effects of Exercise on Atherosclerosis in Mice
Meilhac, O., Ramachandran, S., Chiang, K. T., Santanam, N., & Parthasarathy, S. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1001.097106 · Cited by 133
Weight Loss in Combination With Physical Activity Improves Endothelial Dysfunction in Human Obesity
Sciacqua, A., Candigliota, M., Ceravolo, R., Scozzafava, A., Sinopoli, F., Corsonello, A., Sesti, G., & Perticone, F. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1673 · Cited by 135
“In fact, the reduction of IR (19) and enhanced endothelial NOS gene expression (20) are the potential mechanisms by which regular aerobic exercise may increase endothelium-dependent vasodilation.”
Background
Cell-to-cell communication coordinates blood flow control.
Segal, S. S. (1994) · Hypertension · doi:10.1161/01.hyp.23.6.1113 · Cited by 132
Role of Nitric Oxide in Cardiovascular Adaptation to Intermittent Hypoxia
Manukhina, E. B., Downey, H. F., & Mallet, R. T. (2006) · Experimental Biology and Medicine · doi:10.1177/153537020623100401 · Cited by 132
Exercise training improves aortic endothelium-dependent vasorelaxation and determinants of nitric oxide bioavailability in spontaneously hypertensive rats
Graham, D. A., & Rush, J. W. E. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01252.2003 · Cited by 131
“Although these observations are consistent with the lack of Ex-induced alterations in levels of SOD-1 in peripheral arteries from pigs (48) and mice (16) and SOD-2 and catalase protein levels in porcine AEC (37), they are inconsistent with previous reports of elevated SOD-1 protein in porcine AEC after exercise traini…”
BackgroundInfluential
Effect of lower limb exercise on forearm vascular function: contribution of nitric oxide
GREEN, D. J., Cheetham, C., Mavaddat, L., Watts, K., Best, M., Taylor, R. R., & O’Driscoll, G. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00049.2002 · Cited by 132
The effects of exercise and exercise-related changes in blood nitric oxide level on migraine headache
Narin, S., Pınar, L., Erbas, D., Öztürk, V., & İdiman, F. (2003) · Clinical Rehabilitation · doi:10.1191/0269215503cr657oa · Cited by 128
Upregulation of Nitric Oxide Synthase Correlates Temporally With Onset of Pulmonary Vascular Remodeling in the Hypoxic Rat
Xue, C., & Johns, R. A. (1996) · Hypertension · doi:10.1161/01.hyp.28.5.743 · Cited by 128
Wall Remodeling During Luminal Expansion of Mesenteric Arterial Collaterals in the Rat
Unthank, J. L., Fath, S. W., Burkhart, H. M., Miller, S. C., & Dalsing, M. C. (1996) · Circulation Research · doi:10.1161/01.res.79.5.1015 · Cited by 126
Enhanced Release of Nitric Oxide in Response to Changes in Flow and Shear Stress in the Superior Mesenteric Arteries of Portal Hypertensive Rats
Hori, N., Wiest, R., & Groszmann, R. J. (1998) · Hepatology · doi:10.1002/hep.510280604 · Cited by 127
Increased Activity of Constitutive Nitric Oxide Synthase in Cardiac Endothelium in Spontaneous Hypertension
Nava, E., Noll, G., & Lüscher, T. F. (1995) · Circulation · doi:10.1161/01.cir.91.9.2310 · Cited by 125
Exercise and Cardiovascular Health
Dimmeler, S., & Zeiher, A. M. (2003) · Circulation · doi:10.1161/01.cir.0000074244.82874.a0 · Cited by 128
Preserved flow-mediated dilation in the inactive legs of spinal cord-injured individuals
de Groot, P. C. E., Poelkens, F., Kooijman, M., & Hopman, M. T. E. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00958.2003 · Cited by 124
“Previously, it has been shown that NOS gene expression in endothelial cells is augmented after exposure to increased shear stress levels (49) and similar observations were made in animal training studies, where repeated episodes of increased shear stress seemed to be the basis for a NOS mRNA upregulation (42).”
Enhanced External Counterpulsation and Future Directions
Manchanda, A., & Soran, O. Z. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.07.024 · Cited by 123
Effects of exercise on endothelium and endothelium/smooth muscle cross talk: role of exercise-induced hemodynamics
Newcomer, S. C., Thijssen, D. H. J., & GREEN, D. J. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00033.2011 · Cited by 123
Exercise training improves ageing‐induced decrease in eNOS expression of the aorta
Tanabe, T., Maeda, S., Miyauchi, T., Iemitsu, M., Takanashi, M., Irukayama‐Tomobe, Y., Yokota, T., Ohmori, H., & Matsuda, M. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01100.x · Cited by 122
Responses of Bone Cells to Biomechanical Forces in Vitro
Burger, E. H., & Klein‐Nulend, J. (1999) · Advances in Dental Research · doi:10.1177/08959374990130012201 · Cited by 122
“This NOS isoform is bound to the plasma membrane and regulates the production of NO by endothelial cells in response to enhanced blood flow (Sessa et al, 1994).”
Background
Prolonged Reduction of High Blood Pressure With Human Nitric Oxide Synthase Gene Delivery
Lin, K.-F., Chao, L., & Chao, J. (1997) · Hypertension · doi:10.1161/01.hyp.30.3.307 · Cited by 118
Exercise Training Increases Basal Nitric Oxide Production From the Forearm in Hypercholesterolemic Patients
Lewis, T. V., Dart, A. M., Chin-Dusting, J. P. F., & Kingwell, B. A. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.11.2782 · Cited by 119
Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training
Davis, M. E., Cai, H. “., McCann, L. A., Fukai, T., & Harrison, D. G. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00918.2002 · Cited by 119
“This has been demonstrated in dogs, mice, rats, and pigs (11, 20, 21, 23, 28).”
Background
Aquaporin-1 and endothelial nitric oxide synthase expression in capillary endothelia of human peritoneum
Devuyst, O., Nielsen, S. M., Cosyns, J., et al. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.275.1.h234 · Cited by 118
“These elements are probably involved in the upregulation of eNOS transcript abundance by physiological and pathophysiological factors, such as exercice (29) or hypoxia (2).”
Background
Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice
Claudio Napoli, A., Williams‐Ignarro, S., de Nigris, F., Lerman, L. O., Rossi, L., Guarino, C., Mansueto, G., di Tuoro, F., Pignalosa, O., Rosa, G. D., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402734101 · Cited by 120
Differential effects of arginine methylation on diastolic dysfunction and disease progression in patients with chronic systolic heart failure
Tang, W. H. W., Tong, W. S., Shrestha, K. L., Wang, Z., Levison, B. S., DelFraino, B., Hu, B., Troughton, R. W., Klein, A. L., & Hazen, S. L. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn360 · Cited by 116
“Increased endomyocardial inducible and endothelial NOS gene expression has also been associated with augmented LV diastolic function and reduced diastolic stiffness.(20,22) In addition, chronic inhibition of NOS has been shown in animal models to induce progressive myocardial interstitial and peri-vascular fibrosis th…”
Background
Effects of Short-Term Endurance Training on Aortic Distensibility in Young Males
Kakiyama, T., Sugawara, J., Murakami, H., Maeda, S., Kuno, S., & Matsuda, M. (2005) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000152733.12578.5a · Cited by 115
Regulation of Tetrahydrobiopterin Biosynthesis by Shear Stress
Widder, J. D., Chen, W., Li, L., Dikalov, S., Thöny, B., Hatakeyama, K., & Harrison, D. G. (2007) · Circulation Research · doi:10.1161/circresaha.107.153809 · Cited by 114
Transcriptional Induction of Endothelial Nitric Oxide Synthase Type III by Lysophosphatidylcholine
Zembowicz, A., Tang, J., & Wu, K. K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.17006 · Cited by 117
Endothelium as a Therapeutic Target in Heart Failure
Drexler, H. (1998) · Circulation · doi:10.1161/01.cir.98.24.2652 · Cited by 114
Impact of physical training and detraining on endothelium-dependent vasodilation in patients with recent acute myocardial infarction
Vona, M., Rossi, A., Capodaglio, P., Rizzo, S., Servi, P., Marchi, M. D., & Cobelli, F. (2004) · American Heart Journal · doi:10.1016/j.ahj.2003.12.023 · Cited by 114
Free radicals, antioxidants and international nutrition*
Aruoma, O. I. (1999) · Asia Pacific Journal of Clinical Nutrition · doi:10.1046/j.1440-6047.1999.00036.x · Cited by 113
Polymorphonuclear leucocyte (PMN) inhibitory factor prevents PMN-dependent endothelial cell injury by an anti-adhesive mechanism
Ohno, S., & Malik, A. B. (1997) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199705)171:2 · Cited by 9
Exercise training improves relaxation response and SOD-1 expression in aortic and mesenteric rings from high caloric diet-fed rats
de Moraes, C., Davel, A. P., Rossoni, L. V., Antunes, E., & Zanesco, A. (2008) · BMC Physiology · doi:10.1186/1472-6793-8-12 · Cited by 109
“A number of studies have reported that the beneficial effect of physical training in lowering LDL-cholesterol and increasing HDL-cholesterol particles [10], as well as improving the endothelium-derived relaxing response and lead to a prevention of atherosclerosis due to increased nitric oxide (NO) production and/or it…”
Background
Nitric oxide synthase regulation and diversity: Implications in Parkinson’s disease
Kavya, R., Saluja, R., Singh, S., & Dikshit, M. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.07.003 · Cited by 110
“Shear stress and chronic exercise increase the expression of eNOS [39,40].”
Background
Regulation of Aquaporin-1 and Nitric Oxide Synthase Isoforms in a Rat Model of Acute Peritonitis
Combet, S., Landschoot, M. V., MOULIN, P., et al. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v10102185 · Cited by 109

Authors: Sessa, W. C., Pritchard, K., Seyedi, N., Wang, J., & Hintze, T. H.
Affiliations: New York Medical College (US)
ORCID: Sessa, W C
Pritchard, K
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1994-02
Volume: 74
Issue: 2
Pages: 349-353
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/01.res.74.2.349
OpenAlex: W2125823894
Cited by: 934
References: 0
Citations by year: 2026: 2 · 2025: 6 · 2024: 11 · 2023: 8 · 2022: 10 · 2021: 14 · 2020: 17 · 2019: 15 · 2018: 11 · 2017: 11 · 2016: 18 · 2015: 29 · 2014: 18 · 2013: 16 · 2012: 27
FWCI: 32.87
Type: journal article
Language: en
Open access: closed
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Heart, Lung, and Blood Institute (P01HL043023, P01 HL 43023)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: exercise training, nitric oxide, endothelial nitric oxide synthase, coronary arteries, coronary microvessels, nitrite production, endothelium-derived relaxing factor, acetylcholine, von Willebrand factor, aortic endothelial cells, treadmill running, dogs
MeSH terms: Amino Acid Oxidoreductases, Animals, Coronary Vessels, Dogs, Endothelium, Vascular, Physical Exertion, Female, Male, Nitric Oxide, Nitrites, RNA, Time Factors, Gene Expression, Nitric Oxide Synthase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks