The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Preconditioning of Isolated Rat Heart Is Mediated by Protein Kinase C
Abstract
Abstract Catecholamines have been implicated in the phenomenon of ischemic preconditioning. We have previously demonstrated that ischemic preconditioning against postischemic mechanical dysfunction in the isolated rat heart is mediated by the α 1-adrenergic receptor. The purpose of this study was to delineate the signal transduction of preconditioning distal to the α 1-adrenergic receptor. Our results suggest that (1) transient ischemia and α 1-adrenergic receptor–induced preconditioning is inhibited by protein kinase C (PKC) antagonists, (2) functional protection against global ischemia/reperfusion injury can be induced by infusion of diacylglycerol, the second messenger of the α 1-adrenergic pathway, and (3) transient ischemia and α 1-adrenergic preconditioning are both characterized by similar translocation of PKC-δ to the sarcolemma of myocardium. These findings suggest that PKC is an effector of preconditioning in the isolated rat heart.
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Citations
Cites
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
Cited by
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YELLON, D. M., & DOWNEY, J. M. (2003) · Physiological Reviews · doi:10.1152/physrev.00009.2003 · Cited by 1,062
Tumor necrosis factor in the heart
Meldrum, D. R. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.3.r577 · Cited by 746
Pain, T., Yang, X.-M., Critz, S. D., Yue, Y., Nakano, A., Liu, G. S., Heusch, G., Cohen, M. V., & Downey, J. M. (2000) · Circulation Research · doi:10.1161/01.res.87.6.460 · Cited by 662
α1-Adrenergic Receptor Subtypes: Molecular Structure, Function, and Signaling
Graham, R. M., Perez, D. M., Hwa, J., & Piascik, M. T. (1996) · Circulation Research · doi:10.1161/01.res.78.5.737 · Cited by 522
ATP-Sensitive Potassium Channels: A Review of their Cardioprotective Pharmacology
Grover, G. J., & Garlid, K. D. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1111 · Cited by 396
Metadata
- Authors
- Mitchell, M. B., Meng, X., Ao, L., Brown, J. M., Harken, A. H., & Banerjee, A.
- Venue
- Circulation Research
- Published
- 1995-01
- Volume
- 76
- Issue
- 1
- Pages
- 73-81
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2139834613
- Cited by
- 424
- References
- 1
- FWCI
- 40.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mitchell, M. B., Meng, X., Ao, L., Brown, J. M., Harken, A. H., & Banerjee, A. (1995). Preconditioning of Isolated Rat Heart Is Mediated by Protein Kinase C. Circulation Research. https://doi.org/10.1161/01.res.76.1.73
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
