The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Phospholamban: A Prominent Regulator of Myocardial Contractility
Abstract
Our understanding of the role of phospholamban in cardiac physiology has evolved over the past two decades to the point where this protein is now understood to be a critical repressor of myocardial contractility. Phospholamban, through its inhibitory effects on the affinity of the cardiac sarcoplasmic reticulum Ca2+ pump for Ca2+, represses both the rates of relaxation and contraction in the mammalian heart. These inhibitory effects can be relieved through (1) phospholamban phosphorylation, (2) down-regulation of phospholamban gene expression, and (3) disruption of the phospholamban-Ca(2+)-ATPase interaction. Thus, genetic approaches and pharmacological interventions, designed to relieve the phospholamban inhibitory action on the cardiac sarcoplasmic reticulum Ca2+ pump and myocardial relaxation, may prove valuable in reversing the effects of several diseases in the mammalian heart. Such interventions could be designed to inhibit the phospholamban phosphatase, stabilize the phosphorylated state of phospholamban, interrupt the phospholamban-Ca(2+)-ATPase interaction, decrease phospholamban transcription, or disrupt phospholamban mRNA stability. Development of such therapeutic strategies to target phospholamban will be an important future goal for the clinical improvement of contractility in the failing heart.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Luo, W., Grupp, I. L., Harrer, J., Ponniah, S., Grupp, G., Duffy, J. J., Doetschman, T., & Kranias, E. G. (1994) · Circulation Research · doi:10.1161/01.res.75.3.401 · Cited by 706
Self-citationAlterations of Sarcoplasmic Reticulum Proteins in Failing Human Dilated Cardiomyopathy
Meyer, M., Schillinger, W., Pieske, B., Holubarsch, C., Heilmann, C., Posival, H., Kuwajima, G., Mikoshiba, K., Just, H., & Hasenfuss, G. (1995) · Circulation · doi:10.1161/01.cir.92.4.778 · Cited by 535
Arai, M., Alpert, N. R., MacLennan, D. H., Barton, P., & Periasamy, M. (1993) · Circulation Research · doi:10.1161/01.res.72.2.463 · Cited by 479
Tada, M., Kirchberger, M. A., Repke, D. I., & Katz, A. M. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42237-0 · Cited by 406
Schwinger, R. H. G., Böhm, M., Schmidt, U., Karczewski, P., Bavendiek, U., Flesch, M., Krause, E.-G., & Erdmann, E. (1995) · Circulation · doi:10.1161/01.cir.92.11.3220 · Cited by 395
Lindemann, J. P., Jones, L. R., Hathaway, D. R., Henry, B. G., & Watanabe, A. M. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33279-4 · Cited by 355
Kadambi, V. J., Ponniah, S., Harrer, J. M., Hoit, B. D., Dorn, G. W., Walsh, R. A., & Kranias, E. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118446 · Cited by 327
Self-citationPhospholamban Phosphorylation in Intact Ventricles
Wegener, A. D., Simmerman, H. K., Lindemann, J. P., & Jones, L. R. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60487-9 · Cited by 300
Kiss, E., Jakab, G., Kranias, E. G., & Edes, I. (1994) · Circulation Research · doi:10.1161/01.res.75.2.245 · Cited by 263
Self-citationSimmerman, H. K. B., Kobayashi, Y. M., Autry, J. M., & Jones, L. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.10.5941 · Cited by 256
Cited by
Thyroid hormone and the cardiovascular system.
Klein, I., & Ojamaa, K. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102153440707 · Cited by 2,300
Phospholamban: a crucial regulator of cardiac contractility
MacLennan, D. H., & Kranias, E. G. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1151 · Cited by 1,088
Self-citationCalcium Fluxes Involved in Control of Cardiac Myocyte Contraction
Bers, D. M. (2000) · Circulation Research · doi:10.1161/01.res.87.4.275 · Cited by 580
Thyroid hormone and blood pressure regulation
Danzi, S., & Klein, I. (2003) · Current Hypertension Reports · doi:10.1007/s11906-003-0060-7 · Cited by 261
Klein, I., & Danzi, S. (2016) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2015.04.002 · Cited by 218
Metadata
- Authors
- Koss, K. L., & Kranias, E. G.
- Venue
- Circulation Research
- Published
- 1996-12
- Volume
- 79
- Issue
- 6
- Pages
- 1059-1063
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2061245367
- Cited by
- 353
- References
- 32
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Phospholamban: A Prominent Regulator of Myocardial Contractility. https://app.cochat.ai/papers/10.1161/01.res.79.6.1059
- The paper
- Koss, K. L., & Kranias, E. G. (1996). Phospholamban: A Prominent Regulator of Myocardial Contractility. Circulation Research. https://doi.org/10.1161/01.res.79.6.1059
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
